Science China Life Sciences, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 28, 2024
Language: Английский
Nature Medicine, Journal Year: 2024, Volume and Issue: 30(8), P. 2133 - 2147
Published: July 31, 2024
Language: Английский
Citations
19
Communications Biology, Journal Year: 2024, Volume and Issue: 7(1)
Published: Jan. 5, 2024
Abstract Excess body weight (EBW) increases the risk of colorectal cancer (CRC) and is linked to lower colonoscopy compliance. Here, we extensively analyzed 981 metagenome samples from multiple cohorts pinpoint specific microbial signatures their potential capability distinguishing EBW patients with CRC. The gut microbiome displayed considerable variations between lean We identify 44 37 distinct multi-kingdom species differentiating CRC controls in populations, respectively. Unique bacterial-fungal associations are also observed EBW-CRC lean-CRC. Our analysis revealed functions EBW-CRC, including D-Arginine D-ornithine metabolism, lipopolysaccharide biosynthesis. best-performing classifier for comprising 12 bacterial three fungal species, achieved an AUROC 0.90, which was robustly validated across independent (AUROC = 0.96, 0.94, 0.80). Pathogenic Anaerobutyricum hallii , Clostridioides difficile Fusobacterium nucleatum signatures. This work unearths CRC, may contribute precision diagnosis treatment
Language: Английский
Citations
11
mSystems, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 22, 2025
ABSTRACT The gut microbiota is closely associated with inflammatory bowel disease (IBD) and colorectal cancer (CRC). Probiotics such as Clostridium butyricum (CB) or Akkermansia muciniphila (AKK) have the potential to treat However, research on combined therapeutic effects immunomodulatory mechanisms of CB AKK in treating IBD CRC has never been studied. This study evaluates co-administration DSS/AOM-induced colitis-associated CRC. Our results indicate that compared mono-administration, not only significantly alleviates symptoms weight loss, colon shortening, increased Disease Activity Index mice but also regulates composition effectively suppresses colonic responses. In model, a combination loss markedly reduces infiltration macrophages cytotoxic T lymphocytes (CTLs) colon, thereby regulating anti-tumor immunity inhibiting occurrence inflammation-induced addition, we found probiotic therapy can enhance sensitivity immune checkpoint inhibitor anti-mouse PD-L1 (aPD-L1), improving efficacy immunotherapy survival rate mice. Furthermore, fecal transplantation showed transplanting feces from treated into other alleviated tumor loads extended their rate. suggests use two probiotics, AKK, alleviate chronic intestinal inflammation inhibit progression may be natural relatively safe method support host’s against cancer. IMPORTANCE administration opposed single strain, holds considerable promise preventing advancement synergistic effect attributed ability this more modulate microbiota, curb reactions, bolster immunotherapeutic approaches, optimize treatment via transplantation.
Language: Английский
Citations
1
Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)
Published: Sept. 27, 2024
Language: Английский
Citations
6
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(15), P. 8352 - 8352
Published: July 30, 2024
Adipose tissue dysfunction, which is associated with an increased risk of colorectal cancer (CRC), a significant factor in the pathophysiology obesity. Obesity-related inflammation and extracellular matrix (ECM) remodeling promote metastasis (CRCM) by shaping tumor microenvironment (TME). When CRC occurs, metabolic symbiosis cells recruits adjacent adipocytes into TME to supply energy. Meanwhile, abundant immune cells, from adipose blood, are recruited TME, stimulated pro-inflammatory factors triggers chronic local TME. Dysregulated ECM proteins cell surface adhesion molecules enhance further increase contractibility between stromal promotes epithelial-mesenchymal transition (EMT). EMT increases migration invasion surrounding tissues or vessels accelerates CRCM. Colorectal symbiotic microbiota also plays important role promotion In this review, we provide its contributions CRC, special emphasis on adipocytes, macrophages, neutrophils, T ECM, gut progression their microenvironment. We highlight interactions potential therapeutic approaches target these interactions.
Language: Английский
Citations
5
Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)
Published: Feb. 17, 2024
Adenomatous polyps (APs) with inflammation are risk factors for colorectal cancer. However, the role of inflammation-related gut microbiota in promoting progression APs is unknown.
Language: Английский
Citations
4
EMBO Molecular Medicine, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 16, 2025
Abstract The gut microbiome, or the community of microorganisms residing in gastrointestinal tract, has emerged as an important factor breast cancer etiology and treatment. Specifically, impact bacterial populations on therapeutic outcomes is emerging area research. microbiota’s role modifying pharmacokinetics chemotherapy endocrine-targeting therapies can alter drug efficacy toxicity profiles. In addition, microbiome’s capacity to regulate systemic inflammation immune responses may influence effectiveness both conventional immunotherapeutic strategies for treatment cancer. Overall, while bidirectional interactions between microbiome are still being studied, its increasingly recognized. Future research provide more definitive insights help develop personalized harness improve outcomes.
Language: Английский
Citations
0
PLoS ONE, Journal Year: 2025, Volume and Issue: 20(1), P. e0317462 - e0317462
Published: Jan. 27, 2025
The purpose of this study was to look into any potential connections between the occurrence colon cancer and condition body lipid accumulation product (LAP) index. Using data from 2009-2018 National Health Nutrition Examination Survey (NHANES), we performed a cross-sectional analysis with 24,592 individuals. Utilizing multivariate logistic regression modelling, relationship LAP levels risk investigated. Subgroup analysis, trend test, interaction stratified smoothed curve were also carried out. positively correlated after controlling for covariates (OR = 10.56, 95% CI: 2.40-46.53), findings tests are statistically significant. In particular groups, subgroup revealed positive connection cancer. association shown be M-shaped in group under 60 years old, inverted V-shaped female no-diabetes L-shaped smoking no-hypertensive according fitting. According our findings, there is strong correlation
Language: Английский
Citations
0
Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16
Published: Feb. 7, 2025
The dysregulation of intestinal microbiota has been implicated in the pathogenesis colorectal cancer (CRC). However, utilization for identify lesions different procedures CRC screening populations remains limited. A total 529 high-risk individuals who underwent were included, comprising 13 advanced adenomas (Aade), 5 CRC, 59 non-advanced (Nade), 129 colon polyps (Pol), 99 cases inflammatory disease (Inf), and 224 normal controls (Nor). 16S rRNA gene sequencing was used to profile communities. Gut Microbiota Health Index (GMHI) average variation degree (AVD) employed assess health status groups. Our findings revealed that Nor group exhibited significantly higher GMHIs lowest AVD compared four Lesion model incorporating bacterial genera demonstrated optimal efficacy distinguishing Aade from Nor, with an area under curve (AUC) 0.81 a 95% confidence interval (CI) 0.72 0.89. Specifically, 55 combination superior performance differentiating (AUC 0.98; CI, 0.96-1), 25 showed 0.95). Additionally, 27 Nade 0.82). Inf 0.71). study identified specific microbial biomarkers can differentiate between healthy individuals. markers may serve as valuable tools community-based programs.
Language: Английский
Citations
0
mSystems, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 27, 2025
ABSTRACT Colon cancer (CC) is one of the most common cancers globally, which associated with gut microbiota intimately. In current research, exploring complex interaction between microbiomes and CC a hotspot. However, information on in previous studies based fecal, does not fully display microbial environment CC. Herein, we collected mucosal tissue samples from both tumor normal regions 19 patients clarified composition by 16S rRNA metagenomic sequencing. Additionally, RNA-Seq was also conducted to identify different expression genes samples. We revealed significantly community structures profiles Depending correlation analysis, demonstrated that 1,472 were correlated microbiota. Our study reveals significant enrichment Campylobacter jejuni mucosa CC, correlates bile secretion. observe negative C. immune cells CD4+ Tem mast cells. Finally, discovered metabolic bacterial endosymbiont Bathymodiolus sp., Bacillus wiedmannii , Mycobacterium tuberculosis had survival value for ignored research. Overall, our expands understanding interplay provides new targets treatment IMPORTANCE This contributes colon (CC). By examining rather than solely relying fecal samples, have uncovered previously unknown aspects CC-associated findings reveal distinct gene progression. Notably, mucosa, linked secretion, underscores potential mechanisms pathogenesis. observed correlations taxa cell populations offer avenues immunotherapy research Importantly, this introduces implications expanding therapeutic beyond conventional strategies. elucidating these correlations, only uncovering role but establishes foundation mechanistic cancer, emphasizing broader impact biology.
Language: Английский
Citations
0