Myricetin alleviates high-fat diet-induced atherosclerosis in ApoE-/- mice by regulating bile acid metabolism involved in gut microbiota remodeling

Food & Function, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Myricetin exerts protective effect against atherosclerosis in high-fat diet-induced ApoE −/− mice by modulating the gut-liver axis.

Language: Английский

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Clostridium butyricum Regulates the Inflammatory and Immunoregulatory Pathway Through NFKB1 in Colorectal Cancer Treatment

Probiotics and Antimicrobial Proteins, Journal Year: 2025, Volume and Issue: unknown

Published: April 25, 2025

Language: Английский

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Elucidation of the antipyretic and anti-inflammatory effect of 8-O-Acetyl Shanzhiside methyl ester based on intestinal flora and metabolomics analysis

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 28, 2025

Introduction Phlomoides rotata (Benth. ex Hook.f.) Mathiesen (syn. Lamiophlomis Kudô) ( P. rotate ) is a traditional Tibetan medicine known for its hemostatic, analgesic, and anti-inflammatory effects, as well high content of 8- O -Acetyl Shanzhiside methyl ester (8- aS). Clinical experimental studies have reported gastrointestinal side such diarrhea, loose stools, even to black associated with . Given the bitter taste characteristic, laxative antipyretic effects iridoid glycosides, this study aims investigate aS (the primary glycosides on yeast-induced pyrexia in rats. Additionally, role modulating intestinal flora composition metabolome profile explored. Methods The pyretic rat model was established by injected subcutaneously 20% dry yeast suspension. Serum, hypothalamic tissues colon were collected assessment relevant indicators. peripheral inflammatory factors central thermoregulatory mediators assessed using enzyme-linked immunosorbent assay (ELISA). expressions mRNA protein tissue evaluated through polymerase chain reaction (PCR), immunohistochemistry, western blotting. 16S rDNA sequencing LC-MS/MS performed determine alteration correlation neurotransmitters colonic contents hypothalamus. Results discussion: show that treatment reduced pyrogenic cytokines (such IL-6, IL-1β), down-regulated level (PGE 2 ), via multiply involved TLR4/NF-κB HSP70/NF-κB signaling pathways. Crucially, significantly relative abundance Alistipes P < 0.01), Odoribacter 0.05) Alistipes_finegoldii flora. analysis demonstrated correlated increasing levels 5-hydroxytryptamine tryptamine 0.01). Our findings indicate exhibits significant properties, potentially mediated metabolites neurotransmitters. results may help elucidate mechanism based metabolomics analysis.

Language: Английский

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An overview of chemically induced rodent models for sporadic colorectal cancer: Histopathological and translational perspectives.

PubMed, Journal Year: 2024, Volume and Issue: 39(6), P. 691 - 702

Published: June 1, 2024

Globally, colorectal cancer (CRC) is one of the most frequently diagnosed human gastrointestinal neoplasia and second leading cause cancer-related death in both men women. Despite considerable efforts currently devoted to study biology treatment CRC, patient prognosis survival are still poor. Sporadic CRC a complex multistep disease usually emerges setting lifestyle dietary changes mainly observed industrialized countries with high development index (HDI) (westernized style). The molecular pathogenesis sporadic presents genetic heterogeneity

Language: Английский

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The dual role of 20(S)-protopanaxadiol in alleviating pulmonary fibrosis through the gut-lung axis

Phytomedicine, Journal Year: 2024, Volume and Issue: 129, P. 155699 - 155699

Published: May 1, 2024

Language: Английский

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Systematic review: The gut microbiota as a link between colorectal cancer and obesity

Obesity Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 29, 2024

Summary Microbiome modulation is one of the novel strategies in medicine with greatest future to improve health individuals and reduce risk different conditions, including metabolic, immune, inflammatory, degenerative diseases, as well cancer. Regarding latter, many studies have reported role gut microbiome carcinogenesis, formation progression colorectal cancer (CRC), its response systemic therapies. Likewise, obesity, most important factors for CRC, also known association dysbiosis. Moreover, obesity CRC display, apart from microbial dysbiosis, chronic inflammation, which participates their pathogenesis. Although human murine demonstrate significant impact regulating energy metabolism development, little understood about contribution development obesity‐associated CRC. Therefore, this systematic review explores evidence changes associated these conditions hypothesizes that may contribute pathogenesis obesity‐related Two databases were searched, on relationship among intestinal microbiota clinical preclinical models selected. Data extraction was carried out by two reviewers independently, 101 finally considered. Findings indicate existence a between derived disorders.

Language: Английский

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Sex differences in colonic gene expression and fecal microbiota composition in a mouse model of obesity-associated colorectal cancer

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Feb. 13, 2024

This study investigated the sex-specific correlation between obesity and colorectal cancer emphasizing a more pronounced association in males. Estrogen, chromosomal genes, gut bacteria were assessed C57BL6/J male, female ovariectomized (OVX) mice, subjected to either low-fat diet (LFD) or high-fat (HFD) for 14 weeks. Induction of colon tumor involved azoxymethane (10 mg/kg) administration, followed by three cycles dextran sulfate sodium. Male mice on HFD exhibited higher final body weight increased tumors compared females. Colonic mucin 2 expression was significantly HFD-modulated differentially expressed genes numbered 290 males, 64 females, 137 OVX Only one up-regulated gene (Gfra3) overlapped females while two down-regulated (Thrsp Gbp11) males Genes linked cytokine-cytokine interaction, HIF-1 signaling pathway, central carbon metabolism cancer. Sex-specific changes microbial composition response observed. These findings suggest male-specific vulnerability HFD-induced formation, implicating key colonic tumorigenesis.

Language: Английский

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Influence of bisphenol A and its analogues on human gut microbiota composition and metabolic activity: Insights from an in vitro model

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 956, P. 177323 - 177323

Published: Nov. 6, 2024

Language: Английский

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Association analysis of gut microbiota with LDL-C metabolism and microbial pathogenicity in colorectal cancer patients

Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)

Published: Nov. 8, 2024

Colorectal cancer (CRC) is the most common gastrointestinal malignancy worldwide, with obesity-induced lipid metabolism disorders playing a crucial role in its progression. A complex connection exists between gut microbiota and development of intestinal tumors through metabolite pathway. Metabolic frequently alter microbiome, impairing immune cellular functions hastening

Language: Английский

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Transplant of gut microbiota ameliorates metabolic and heart disorders in rats fed with a hypercaloric diet by modulating microbial metabolism and diversity

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 181, P. 117667 - 117667

Published: Nov. 15, 2024

Language: Английский

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