Bridging Smart Nanosystems with Clinically Relevant Models and Advanced Imaging for Precision Drug Delivery
Qiaoxia Zhou,
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Qiongliang Liu,
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Yan Wang
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et al.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(14)
Published: Jan. 28, 2024
Abstract
Intracellular
delivery
of
nano‐drug‐carriers
(NDC)
to
specific
cells,
diseased
regions,
or
solid
tumors
has
entered
the
era
precision
medicine
that
requires
systematic
knowledge
nano‐biological
interactions
from
multidisciplinary
perspectives.
To
this
end,
review
first
provides
an
overview
membrane‐disruption
methods
such
as
electroporation,
sonoporation,
photoporation,
microfluidic
delivery,
and
microinjection
with
merits
high‐throughput
enhanced
efficiency
for
in
vitro
NDC
delivery.
The
impact
characteristics
including
particle
size,
shape,
charge,
hydrophobicity,
elasticity
on
cellular
uptake
are
elaborated
several
types
systems
aiming
hierarchical
targeting
vivo
reviewed.
Emerging
ex
human/animal‐derived
pathophysiological
models
further
explored
highly
recommended
use
studies
since
they
might
mimic
features
fill
translational
gaps
animals
humans.
exploration
modern
microscopy
techniques
precise
nanoparticle
(NP)
tracking
at
cellular,
organ,
organismal
levels
informs
tailored
development
NDCs
application
clinical
translation.
Overall,
integrates
latest
insights
into
smart
nanosystem
engineering,
physiological
models,
imaging‐based
validation
tools,
all
directed
towards
enhancing
efficient
intracellular
NDCs.
Language: Английский
Histopathological analysis of tumor microenvironmental changes after near-infrared photoimmunotherapy
Tadasu Chida,
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Aya Matsuda,
No information about this author
Nako Maishi
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et al.
Journal of Oral and Maxillofacial Surgery Medicine and Pathology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Language: Английский
Photoinduced Actin Aggregation Involves Cell Death: A Mechanism of Cancer Cell Cytotoxicity after Near-Infrared Photoimmunotherapy
ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 18, 2025
Near-infrared
photoimmunotherapy
(NIR-PIT)
is
a
cancer
treatment
modality
that
uses
antibody-photoabsorber
(IR700)
conjugates
to
destroy
specific
cells.
The
reaction
between
the
antibody
and
photoabsorber
triggered
by
NIR-light,
this
alters
shape
hydrophilicity
of
conjugate.
This
photochemical
responsible
for
NIR-PIT-induced
cell
death;
however,
detailed
mechanism
underlying
effect
remains
unknown.
In
study,
we
demonstrated
actin
filaments
underneath
membrane
play
an
important
role
in
death
IR700
mediates
conjugates,
leading
filament
aggregation
upon
NIR-light
irradiation.
destruction
cortical
beneath
plasma
allows
water
flow
into
based
on
osmotic
conditions,
resulting
rupture.
sequence
events
may
constitute
death,
making
NIR-PIT
promising
modality.
Language: Английский
Continuous Non-Invasive Gastric Volume Monitoring Using GMR Sensors and Machine Learning for Gastrointestinal Wellness
Dhakshunhaamoorthiy,
No information about this author
A. Jawahar,
No information about this author
P. Girija
No information about this author
et al.
Published: May 24, 2024
Language: Английский
近红外光免疫治疗策略靶向肿瘤微环境的研究进展
崔瀛书 Cui Yingshu,
No information about this author
李怡 Li Yi,
No information about this author
李晓松 Li Xiaosong
No information about this author
et al.
Chinese Journal of Lasers,
Journal Year:
2024,
Volume and Issue:
51(9), P. 0907010 - 0907010
Published: Jan. 1, 2024
近红外光免疫治疗(NIR-PIT)是一种结合抗体和光吸收剂IRDye700DX的新型肿瘤疗法,它既能够激活局部免疫效应,又能够增强肿瘤靶向性,已在不同肿瘤类型的治疗中显示出巨大的应用潜力。大量研究已经证实肿瘤微环境是导致肿瘤不断发展的重要原因,因此NIR-PIT中的光免疫偶联物靶点也已经扩展至肿瘤微环境中非肿瘤细胞的表面蛋白中。利用NIR-PIT局部消除肿瘤微环境中某些具有特定标志物的免疫抑制细胞、血管或肿瘤成纤维细胞,将解除免疫抑制,最大效率发挥机体的正常免疫功能,取得最佳的疗效。主要综述了NIR-PIT的治疗策略和靶向肿瘤微环境的最新研究进展。