A Review of Anticancer Properties and Phytochemicals from Xao tam phan (Paramignya trimera (Oliv.) Guillaum)

Natural Product Communications, Journal Year: 2025, Volume and Issue: 20(1)

Published: Jan. 1, 2025

Paramignya trimera ( P. (Oliv.) Guillaum), a Vietnamese plant has showed potential anticancer activities. Extracts from the plant's roots, stems, and leaves have shown cytotoxicity against variety of cancer cell lines. The mechanisms behind these actions include triggering apoptosis, blocking invasion, targeting particular signaling pathways. This review collected data available literature on trimera's properties compiled database its isolated compounds. Results indicate that extracts specific compounds, such as coumarins acridones, possess potential. Particularly, acridones exhibited comparable or superior HepG2 MCF-7 cells (IC 50 values 0.43-1.19 μM 0.22-0.40 μM, respectively) compared to doxorubicin 0.28 1.31 μM). Coumarins like 8-geranylumbelliferone ostruthin target IKKβ, while paratrimerin W shows various cancers. Paratrimerin I exhibit due N-methyl, C-4 methoxy, C-5 hydroxy groups in acridone skeleton. However, further research is needed elucidate precise action evaluate safety efficacy trimera-derived compounds clinical settings. identification 146 provides valuable resource for future drug discovery efforts.

Language: Английский

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Sorafenib and Treg Differentiation: A Paradigm Shift in Hepatocellular Carcinoma Management

Cellular and Molecular Gastroenterology and Hepatology, Journal Year: 2025, Volume and Issue: unknown, P. 101478 - 101478

Published: Feb. 1, 2025

Language: Английский

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T lymphocyte-based immune response and therapy in hepatocellular carcinoma: focus on TILs and CAR-T cells

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

Language: Английский

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Comprehensive Profiling of Candidate Biomarkers and Immune Infiltration Landscape in Metabolic Dysfunction-Associated Steatohepatitis

Metabolism Open, Journal Year: 2025, Volume and Issue: unknown, P. 100366 - 100366

Published: April 1, 2025

Language: Английский

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Chronic Inflammation and Immune Dysregulation in Metabolic-Dysfunction-Associated Steatotic Liver Disease Progression: From Steatosis to Hepatocellular Carcinoma

Biomedicines, Journal Year: 2025, Volume and Issue: 13(5), P. 1260 - 1260

Published: May 21, 2025

Background/Objectives: Metabolic-dysfunction-associated steatotic liver disease (MASLD) progresses from hepatic steatosis to hepatocellular carcinoma (HCC) as a result of systemic immunometabolic dysfunction. This review summarizes the key roles innate and adaptive immune mechanisms driving injury, fibrogenesis, carcinogenesis in MASLD. Methods: A comprehensive literature was performed using PubMed identify relevant published studies. Eligible articles included original research clinical studies addressing immunological metabolic MASLD, well emerging therapeutic strategies. Results: We highlight cytokine networks, gut–liver axis, cell reprogramming. Emerging strategies, including inhibitors, anti-fibrotic agents, modulators, nutraceuticals, offer several indications for attenuating MASLD progression reducing prevalence extrahepatic manifestations. Conclusions: Given heterogeneity personalized combination-based approaches targeting both inflammation stress are essential effective management prevention complications.

Language: Английский

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Immune system dysregulation in the pathogenesis of non-alcoholic steatohepatitis: unveiling the critical role of T and B lymphocytes

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 1, 2024

Non-alcoholic fatty liver disease (NAFLD), characterized by the excessive accumulation of fat within cytoplasm hepatocytes (exceeding 5% weight) in individuals without significant alcohol consumption, has rapidly evolved into a pressing global health issue, affecting approximately 25% world population. This condition, closely associated with obesity, type 2 diabetes, and metabolic syndrome, encompasses spectrum disorders ranging from simple steatosis inflammation to non-alcoholic steatohepatitis (NASH) cirrhotic disease. Recent research illuminated complex interplay between immune responses pathogenesis NASH, underscoring critical role played T B lymphocytes. These cells not only contribute necroinflammatory changes hepatic lobules but may also drive onset progression fibrosis. narrative review aims provide comprehensive exploration effector mechanisms employed cells, their respective subpopulations NASH. Understanding immunological complexity NASH holds profound implications for development targeted immunotherapeutic strategies combat this increasingly prevalent burdensome

Language: Английский

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Prognostic Impact of Metabolic Syndrome and Steatotic Liver Disease in Hepatocellular Carcinoma Using Machine Learning Techniques

Metabolites, Journal Year: 2024, Volume and Issue: 14(6), P. 305 - 305

Published: May 27, 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD) currently represents the predominant cause of chronic and is closely linked to a significant increase in risk hepatocellular carcinoma (HCC), even absence cirrhosis. In this retrospective multicenter study, machine learning (ML) methods were employed investigate relationship between metabolic profile prognosis at diagnosis total 219 HCC patients. The eXtreme Gradient Boosting (XGB) method demonstrated superiority identifying mortality predictors our Etiology was most determining prognostic factor followed by Barcelona Clinic Liver Cancer (BCLC) Eastern Cooperative Oncology Group (ECOG) classifications. Variables related development hepatic steatosis syndrome, such as elevated levels alkaline phosphatase (ALP), uric acid, obesity, alcohol consumption, high blood pressure (HBP), had impact on prediction. This study underscores importance syndrome progression secondary MASLD. use ML techniques provides an effective tool improve stratification individualized therapeutic management these

Language: Английский

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Invariant Natural Killer T cells control positively and negatively the development of hepatocellular carcinoma

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 30, 2024

Abstract The liver routinely encounters antigens from the gut, triggering pro- inflammatory responses. Unresolved inflammation can lead to damage, steatosis, fibrosis, cirrhosis, and eventually hepatocellular carcinoma (HCC). HCC is influenced by various immune cells, including invariant natural killer T (iNKT) which exhibit both innate adaptive immunity traits. Here, we examined iNKT cell dynamics in a diethyl-nitrosamine (DEN)-induced mouse model. We observed significant reduction numbers livers due apoptosis impaired cytokine production. CD1d -deficient mice, lack displayed delayed tumor initiation lower foci number. However, these tumors were larger size characterized enhanced proliferation immunosuppression. Interestingly, adoptive transfer of healthy cells post-tumor establishment reduced burden, highlighting their potential therapeutic role. Our findings suggest that contribute early development, while later stages they help control growth, thus underscoring complex role carcinogenesis. Further understanding functions may inform novel immunotherapeutic strategies for management.

Language: Английский

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Enhancing Regulatory T cell function by mevalonate pathway inhibition prevents liver fibrosis

Biochemical and Biophysical Research Communications, Journal Year: 2024, Volume and Issue: 742, P. 151094 - 151094

Published: Nov. 29, 2024

Language: Английский

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