JDDG Journal der Deutschen Dermatologischen Gesellschaft, Journal Year: 2025, Volume and Issue: unknown
Published: May 9, 2025
Language: Английский
Cell, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 1, 2024
Language: Английский
Citations
39
Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 15
Published: Feb. 4, 2025
The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome 2 (SARS-CoV-2) virus, has presented multifaceted health challenges. COVID-19 primarily targets system but also affects multiple organ systems, including endocrine system. Emerging evidence suggests interactions between thyroid function, phase of COVID-19, and prolonged symptoms known as post-COVID sequalae or long COVID. Several studies have reported that can induce dysfunction, leading to conditions such thyroiditis alterations in hormone levels. mechanisms through which SARS-CoV-2 include direct viral infection cells, thyroiditis, causes inflammation transient sustained well an excessive systemic immune response (cytokine storm). This is associated with elevated levels cytokines, IL-6, disrupt function lead nonthyroidal illness (NTIS). Medications administered during phase, corticosteroids antiviral drugs, impact actions. involvement gland COVID, postacute sequelae infection, area not defined, potential implications for understanding managing this condition. Persistent low-grade affecting over time ongoing exacerbate pre-existing conditions. Viral infections, SARS-CoV-2, trigger worsen autoimmune diseases, Hashimoto’s Graves’ disease. Long COVID may hypothalamic–pituitary–adrenal (HPA) axis, can, turn, affect hypothalamic-pituitary-thyroid (HPT) abnormal function. review was designed systematically capture recent literature on COVID-19-related dysfunction adult population, prognostic consequences effects patients A comprehensive search PubMed EMBASE databases conducted. systematic performed based Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA) statement. Study quality assessed using Critical Appraisal Skills Programme (CASP). total 53 met inclusion criteria. summarises findings provides update current spectrum disorders, underscoring complex nature its far-reaching impacts human health.
Language: Английский
Citations
3
medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: June 19, 2024
Acute SARS-CoV-2 infection triggers the generation of diverse and functional autoantibodies (AABs), even after mild cases. Persistently elevated have been found in some individuals with long COVID (LC). Using a >21,000 human protein array, we identified AAB targets LC patients that correlated their symptoms. Elevated AABs to proteins nervous system were neurocognitive neurological Purified Immunoglobulin G (IgG) samples from these reacted pons tissue cross-reactive mouse sciatic nerves, spinal cord, meninges. Antibody reactivity nerves meninges patient-reported headache disorientation. Passive transfer IgG mice led increased sensitivity pain, mirroring Similarly, injected showed loss balance coordination, reflecting donor-reported dizziness. Our findings suggest targeting could benefit patients.
Language: Английский
Citations
15
American Journal of Medicine Open, Journal Year: 2024, Volume and Issue: 11, P. 100068 - 100068
Published: Feb. 14, 2024
The virus called SARS-CoV-2 emerged in 2019 and quickly spread worldwide, causing COVID-19. It has greatly impacted on everyday life, healthcare systems, the global economy. In order to save as many lives possible, precautions such social distancing, quarantine, testing policies were implemented, effective vaccines developed. A growing amount of data collected worldwide allowed characterization this new disease, which turned out be more complex than other common respiratory tract infections. An increasing number convalescents presented with a variety non-specific symptoms emerging after acute infection. This possible health problem was identified labelled long COVID. Since then, great effort been made by clinicians scientific community understand underlying mechanisms develop preventive measures treatment. role autoimmunity induced infection development COVID is discussed review. We aim deliver description several conditions an autoimmune background observed COVID-19 convalescents, including Guillain-Barré syndrome, antiphospholipid syndrome related thrombosis, Kawasaki disease highlighting relationship between autoimmunity. However, further studies are required determine its true clinical significance.
Language: Английский
Citations
14
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(12), P. 6389 - 6389
Published: June 9, 2024
Long COVID (LC), also referred to as Post COVID-19 Condition, Post-Acute Sequelae of SARS-CoV-2 Infection (PASC), and other terms, represents a complex multisystem disease persisting after the acute phase COVID-19. Characterized by myriad symptoms across different organ systems, LC presents significant diagnostic management challenges. Central disorder is role low-grade inflammation, non-classical inflammatory response that contributes chronicity diversity observed. This review explores pathophysiological underpinnings LC, emphasizing importance inflammation core component. By delineating pathogenetic relationships clinical manifestations this article highlights necessity for an integrated approach employs both personalized medicine standardized protocols aimed at mitigating long-term consequences. The insights gained not only enhance our understanding but inform development therapeutic strategies could be applicable chronic conditions with similar features.
Language: Английский
Citations
9
Cancer Immunology Immunotherapy, Journal Year: 2025, Volume and Issue: 74(2)
Published: Jan. 3, 2025
Language: Английский
Citations
1
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15
Published: Jan. 6, 2025
Few pathogens have historically been subjected to as intense scientific and clinical scrutiny SARS-CoV-2. The genetic, immunological, environmental factors influencing disease severity post-infection outcomes, known correlates of immunity, remain largely undefined. Clinical outcomes SARS-CoV-2 infection vary widely, ranging from asymptomatic cases those with life-threatening COVID-19 symptoms. While most infected individuals return their former health fitness within a few weeks, some develop debilitating chronic symptoms, referred long-COVID. Autoimmune responses proposed one the long-COVID infection. association between viral infections autoimmune pathologies is not new. Viruses such Epstein-Barr virus cytomegalovirus, among others, shown induce production autoantibodies onset conditions. Given extensive literature on SARS-CoV-2, here we review current evidence SARS-CoV-2-induced pathologies, focus autoantibodies. We closely examine mechanisms driving autoantibody production, particularly connection
Language: Английский
Citations
1
Rheumatology International, Journal Year: 2025, Volume and Issue: 45(1)
Published: Jan. 15, 2025
Language: Английский
Citations
1
Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)
Published: Feb. 12, 2025
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a prototypic autoimmune disease, with subset of AAV patients manifesting anti-myeloperoxidase (MPO) IgG. Patients respond positively to B cell-targeting and complement-targeting therapies, but disease flares are not uncommon. Here, by comparing samples from healthy individuals MPO+ AVV patients, we show that cell autoreactivity against MPO in the circulation dominated CD27+IgM+ cells whereas MPO-specific IgG+ infrequent. Additionally, while naive anti-MPO-IgM present both controls produce anti-MPO IgM upon stimulation, memory serum features patients. Our results thus hint defective elimination reactivity human repertoire, presence activated IgM+ dominant role for complement activation, may all contribute etiology thereby serve as potential target therapy. The anti-neutrophil still poorly understood. Here authors associate IgM-expressing cells, addition IgG pathophysiology implicate targets
Language: Английский
Citations
1
Rheumatology Science and Practice, Journal Year: 2024, Volume and Issue: 62(1), P. 32 - 54
Published: Feb. 29, 2024
The pandemic of coronavirus disease 2019 (COVID-19), etiologically related to the SARS-CoV-2 virus (severe acute respiratory syndrome coronavirus-2), has drawn attention new clinical and fundamental problems in immunopathology human diseases associated with virus-induced autoimmunity autoinflammation. provision that “the experience gained rheumatology process studying pathogenetic mechanisms pharmacotherapy immunoinflammatory rheumatic as most common severe forms autoimmune autoinflammatory pathology humans will be demand for deciphering nature pathological processes underlying COVID-19 developing approaches effective pharmacotherapy” was confirmed numerous studies conducted over next 3 years midst pandemic. main focus on a critical analysis data regarding role inflammation, which basis pathogenesis immune-mediated context COVID-19.
Language: Английский
Citations
9