Predictability of varicocele repair success: preliminary results of a machine learning-based approach DOI Creative Commons
Andrea Crafa, Marco Russo, Rossella Cannarella

et al.

Asian Journal of Andrology, Journal Year: 2024, Volume and Issue: 27(1), P. 52 - 58

Published: Aug. 9, 2024

Abstract Varicocele is a prevalent condition in the infertile male population. However, to date, which patients may benefit most from varicocele repair still matter of debate. The purpose this study was evaluate whether certain preintervention sperm parameters are predictive successful repair, defined as an improvement total motile count (TMSC). We performed retrospective on 111 with who had undergone collected Department Endocrinology, Metabolic Diseases and Nutrition, University Catania (Catania, Italy), Unit Urology at Selcuk School Medicine (Konya, Türkiye). analysis conducted through use Brain Project, innovative tool that allows complete totally unbiased search mathematical expressions relate object various available. considered when TMSC increased by least 50% value. For below 5 × 10 6 , clinically relevant increase exceeded absolute value >5 . From alone, we found model predicts appear little sensitivity 50.0% specificity 81.8%. grade serum follicle-stimulating hormone (FSH) levels did not play role, but it should be noted all enrolled were selected intermediate- or high-grade normal FSH levels. In conclusion, success terms varicoceles

Language: Английский

The Impact of a Very Short Abstinence Period on Conventional Sperm Parameters and Sperm DNA Fragmentation: A Systematic Review and Meta-Analysis DOI Open Access
Federica Barbagallo, Rossella Cannarella, Andrea Crafa

et al.

Journal of Clinical Medicine, Journal Year: 2022, Volume and Issue: 11(24), P. 7303 - 7303

Published: Dec. 8, 2022

Purpose: In recent years, a growing number of studies have supported the beneficial effects very short abstinence period on sperm parameters, especially in patients with oligoasthenozoospermia. However, results are controversial and no consensus exists regarding whether to request second semen collection clinical practice. Therefore, this systematic review meta-analysis aimed evaluate influence (within 4 h) conventional parameters DNA fragmentation (SDF) rate. Materials Methods: The literature search was performed using Scopus PubMed databases. conducted according Preferred Reporting Items for Systematic Review Meta-Analysis Protocol (PRISMA-P) guidelines. All eligible were selected Population, Intervention, Comparison/Comparator, Outcomes, Study design (PICOS) model. quality evidence included analyzed through Cambridge Quality Checklists. standardized mean difference (SMD) used analyze outcomes. Cochran-Q I2 statistics statistical heterogeneity. Results: We assessed eligibility 1334 abstracts, 19 finally included. articles evaluated and, among these, 5 also SDF quantitative analysis showed significant reduction volume after both normozoospermic men oligozoospermia, asthenozoospermia, and/or teratozoospermia (OAT) patients. found statistically increase concentration total progressive motility ejaculation OAT. contrast, rate decreased significantly ejaculate OAT Conclusions: This is first investigating impact suggest that collecting consecutive time from could represent simple useful strategy obtaining better-quality spermatozoa, abnormal parameters.

Language: Английский

Citations

20
Exposure to potentially toxic elements (PTEs) and the risk of male infertility- A Systematic review and meta-analysis DOI
Mandeep Kaur,

Ahelee Ghosal,

Rajinder Kaur

et al.

Journal of Gynecology Obstetrics and Human Reproduction, Journal Year: 2024, Volume and Issue: 53(6), P. 102782 - 102782

Published: March 28, 2024

Language: Английский

Citations

4
Associations between seminal plasma metals/metalloids and semen quality: A cross-sectional study DOI Creative Commons
Juan Wen,

Xiaodie Yao,

Renjie Lu

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 279, P. 116472 - 116472

Published: May 17, 2024

Exposure to metals/metalloids is reported potentially influence semen quality. While most studies have focused on single metal impacts, the link between exposure multiple metals and quality has remained less explored. The study aimed investigate effects of both individual mixed metal/metalloid A total 330 men were recruited from three reproductive centers in eastern China. Seminal plasma levels 25 sperm parameters determined. We used Generalized Linear Model (GLM) Restricted Cubic Spline (RCS) assess relationships weighted quantile sum (WQS) models then applied evaluate combined effect all these metals/metalloids. observed positive associations lithium (Li), zinc (Zn), magnesium (Mg) with an increased risk below reference values for progressive motility using a logistic regression model (P < 0.05). Additionally, our results also revealed significant inverse relationship aluminum (Al) concentration count, while cobalt (Co) demonstrated association Notably, WQS indicated mixtures abnormal (OR: 1.57; 95%CI: 1.10, 2.24) 1.53; 1.06, 2.19), this primarily driven by Li, Mg, Zn. In summary, findings indicate that might adverse

Language: Английский

Citations

4
Lead Causes Lipid Droplet Accumulation by Impairing Lysosomal Function and Autophagic Flux in Testicular Sertoli Cells DOI Creative Commons

Chengwei Guo,

Lingqiao Wang,

Ke Cui

et al.

Toxics, Journal Year: 2025, Volume and Issue: 13(3), P. 175 - 175

Published: Feb. 28, 2025

Lead (Pb) is one of the most common environmental pollutants that negatively impacts male reproductive health. Thus far, underlying molecular mechanisms Pb-induced toxicity are still not well understood. In this study, 64 ICR mice were given drinking water with Pb (0, 100, 200, and 300 mg/L) for 90 days. We found exposure to mg/L resulted in reduced sperm quality elevated autophagy-related protein levels mouse testes. Our findings indicate hindered autophagic clearance by impairing lysosomes’ function then obstructing fusion lysosomes autophagosomes. The autophagy cycle obstruction prevented lipid droplets from breakdown led their accumulation Sertoli cells. turn, ccytotoxic effects interruption maturation stage, instead elongation phase, could be alleviated either Chloroquine or Bafilomycin A1. Furthermore, 400 μM initiated TFE3 nuclear translocation caused increased expression its target genes. Then, knockdown formation autophagosome. addition, use antioxidant NAC notably enhanced activity occurrence This study demonstrated disrupted flow, which droplet TM4 Consequently, focusing on stage might offer a potential therapeutic approach alleviate exposure.

Language: Английский

Citations

0
Low-level and combined exposure to environmental metal elements affects male reproductive outcomes: Prospective MARHCS study in population of college students in Chongqing, China DOI
Zili Chai, Guanghui Zhang, Xi Ling

et al.

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 828, P. 154395 - 154395

Published: March 8, 2022

Language: Английский

Citations

17
Zinc mitigates cadmium-induced sperm dysfunction through regulating Ca2+ and metallothionein expression in the freshwater crab Sinopotamon henanense DOI
Jing Liu,

Ermeng Wang,

Zhipeng Xi

et al.

Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology, Journal Year: 2024, Volume and Issue: 279, P. 109860 - 109860

Published: Feb. 20, 2024

Language: Английский

Citations

3
Association between spectrum of mycotoxins and semen quality: A cross-sectional study in Beijing, China DOI

Chen Yang,

Ning Xiao, Baojun Wang

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 476, P. 135124 - 135124

Published: July 7, 2024

Language: Английский

Citations

3
Associations between seminal plasma metal mixture and semen quality: A metabolome-mediated case-control study DOI
Shujie Zhao,

Wanting Lu,

Guanxiang Yuan

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 297, P. 118257 - 118257

Published: May 3, 2025

Language: Английский

Citations

0
The Impact of a Very Short Abstinence Period on Assisted Reproductive Technique Outcomes: A Systematic Review and Meta-Analysis DOI Creative Commons
Federica Barbagallo, Rossella Cannarella, Andrea Crafa

et al.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(3), P. 752 - 752

Published: March 20, 2023

Previous studies supported the beneficial effects of a very short abstinence period on sperm quality. This systematic review and meta-analysis aimed to evaluate (within 4 h) assisted reproductive technique (ART) outcomes.

Language: Английский

Citations

9
Environmental and Genetic Traffic in the Journey from Sperm to Offspring DOI Creative Commons
Pallav Sengupta, Sulagna Dutta, Fong Fong Liew

et al.

Biomolecules, Journal Year: 2023, Volume and Issue: 13(12), P. 1759 - 1759

Published: Dec. 7, 2023

Recent advancements in the understanding of how sperm develop into offspring have shown complex interactions between environmental influences and genetic factors. The past decade, marked by a research surge, has not only highlighted profound impact paternal contributions on fertility reproductive outcomes but also revolutionized our comprehension unveiling parental factors sculpt traits successive generations through mechanisms that extend beyond traditional inheritance patterns. Studies are more susceptible to factors, especially during critical phases growth. While these broadly detrimental health, their effects acute periods. Moving immutable nature genome, epigenetic profile cells emerges as dynamic architecture. This flexibility renders it disruptions. primary objective this review is shed light diverse processes which agents affect male capacity. Additionally, explores consequences interactions, demonstrating can reverberate offspring. It encompasses direct changes well broad spectrum adaptations. By consolidating current empirically supported research, offers an exhaustive perspective interwoven trajectories environment, genetics, epigenetics elaborate transition from

Language: Английский

Citations

9