Authorea (Authorea),
Journal Year:
2022,
Volume and Issue:
unknown
Published: June 8, 2022
Objective:
To
investigate
the
associations
of
seminal
plasma
selenium
(Se)
concentrations
with
semen
quality
and
to
explore
mediating
role
sperm
mitochondrial
DNA
copy
number
(mtDNAcn).
Design:
Cross-sectional
study
repeated
measurements.
Setting:
Hubei
Province
Human
Sperm
Bank
China.
Population:
A
total
1159
healthy
men
who
repeatedly
provided
5617
samples
were
included.
Main
Outcome
Measures:
Seminal
Se
concentration
mtDNAcn
screened
as
potential
donors
determined
using
inductively
coupled
mass
spectrometry
(ICP-MS)
real-time
fluorescent
quantitative
PCR
(RT-qPCR),
respectively.
Methods:
Linear
mixed-effects
models
mediation
analyses
performed.
Result(s):
After
adjusting
for
confounders,
we
observed
positive
count
(both
p-Values
trend
<
0.001).
Volunteers
in
highest
vs.
lowest
quartiles
had
70.1%
(95%
CI:
53.3%,
88.9%)
59.1%
40.5%,
80.2%)
higher
count,
We
also
found
inverse
between
within-subject
pooled
mtDNAcn,
concentration,
motility,
progressive
motility
(all
0.05).
Mediation
showed
that
mediated
19.7%
15.9%,
25.3%)
23.1%
17.4%,
33.4%)
average
Conclusions:
positively
associated
which
was
partly
by
mtDNAcn.
Journal of Analytical Atomic Spectrometry,
Journal Year:
2023,
Volume and Issue:
38(3), P. 496 - 577
Published: Jan. 1, 2023
This
review
discusses
developments
in
elemental
mass
spectrometry,
atomic
absorption,
emission
and
fluorescence,
XRF
LIBS,
as
applied
to
the
analysis
of
specimens
clinical
interest,
foods
beverages.
Sample
preparation
procedures
quality
assurance
are
also
included.
Ecotoxicology and Environmental Safety,
Journal Year:
2024,
Volume and Issue:
279, P. 116472 - 116472
Published: May 17, 2024
Exposure
to
metals/metalloids
is
reported
potentially
influence
semen
quality.
While
most
studies
have
focused
on
single
metal
impacts,
the
link
between
exposure
multiple
metals
and
quality
has
remained
less
explored.
The
study
aimed
investigate
effects
of
both
individual
mixed
metal/metalloid
A
total
330
men
were
recruited
from
three
reproductive
centers
in
eastern
China.
Seminal
plasma
levels
25
sperm
parameters
determined.
We
used
Generalized
Linear
Model
(GLM)
Restricted
Cubic
Spline
(RCS)
assess
relationships
weighted
quantile
sum
(WQS)
models
then
applied
evaluate
combined
effect
all
these
metals/metalloids.
observed
positive
associations
lithium
(Li),
zinc
(Zn),
magnesium
(Mg)
with
an
increased
risk
below
reference
values
for
progressive
motility
using
a
logistic
regression
model
(P
<
0.05).
Additionally,
our
results
also
revealed
significant
inverse
relationship
aluminum
(Al)
concentration
count,
while
cobalt
(Co)
demonstrated
association
Notably,
WQS
indicated
mixtures
abnormal
(OR:
1.57;
95%CI:
1.10,
2.24)
1.53;
1.06,
2.19),
this
primarily
driven
by
Li,
Mg,
Zn.
In
summary,
findings
indicate
that
might
adverse
Ecotoxicology and Environmental Safety,
Journal Year:
2023,
Volume and Issue:
251, P. 114532 - 114532
Published: Jan. 12, 2023
Selenium
(Se)
is
essential
for
successful
male
reproduction.
However,
the
association
of
Se
status
with
human
semen
quality
remains
controversial
and
underlying
mechanisms
are
poorly
understood.
We
measured
seminal
plasma
concentrations,
sperm
mitochondrial
DNA
copy
number
(mtDNAcn),
parameters
among
healthy
Chinese
men
screened
as
potential
donors.
Linear
mixed-effects
models
were
used
to
investigate
associations
within-subject
pooled
concentrations
(n
=
1159)
repeated
5617);
mediation
analyses
applied
evaluate
mediating
role
mtDNAcn
989).
Seminal
positively
associated
concentration
total
count
(both
P
trend
<
0.001).
In
adjusted
models,
in
top
vs.
bottom
quartiles
had
70.1
%
(95
CI:
53.3
%,
88.9
%)
59.1
40.5
80.2
higher
count,
respectively.
Meanwhile,
we
observed
inverse
between
mtDNAcn,
motility,
concentration,
(all
0.05).
Mediation
suggested
that
mediated
19.7
15.9
25.3
23.1
17.4
33.4
Our
findings
suggest
spermatogenesis,
potentially
by
affecting
mtDNAcn.
Pharmaceuticals,
Journal Year:
2024,
Volume and Issue:
17(11), P. 1486 - 1486
Published: Nov. 5, 2024
:
Anti-manic
effects
of
lithium
and
the
nature
trace
element
in
were
first
observed
1949.
In
this
review,
we
explore
potential
prevention
suicide
dementia.
Environmental Science & Technology,
Journal Year:
2023,
Volume and Issue:
57(19), P. 7358 - 7369
Published: May 5, 2023
While
exogenous
metal/metalloid
(metal)
exposure
has
been
associated
with
reduced
human
semen
quality,
no
study
assessed
the
associations
of
metals
in
spermatozoa
quality.
Here,
we
developed
a
strategy
to
explore
between
at
single-cell
resolution
and
quality
among
84
men
screened
as
sperm
donors,
who
provided
266
samples
within
90
days.
A
cellular
atlas
level
was
created
mass
cytometry
(CyTOF)
technology,
which
concurrently
displayed
18
more
than
50
000
single
sperm.
Exogenous
were
extremely
heterogeneous
diverse.
Further
analysis
using
multivariable
linear
regression
mixed-effects
models
revealed
that
heterogeneity
prevalence
The
lead
(Pb),
tin
(Sn),
yttrium
(Y),
zirconium
(Zr)
negatively
concentration
count,
while
their
showed
positive
associations.
These
findings
properties
highlighting
importance
assessing
evaluate
male
reproductive
health
risk
precisely.
