Exposure to copper activates mitophagy and endoplasmic reticulum stress‐mediated apoptosis in chicken (Gallus gallus) cerebrum DOI

Yihui Huo,

Feiyang Ma,

Tingyu Li

et al.

Environmental Toxicology, Journal Year: 2022, Volume and Issue: 38(2), P. 392 - 402

Published: Nov. 9, 2022

A large amount of copper (Cu) used in production activities can lead to the enrichment Cu environment, which cause toxicity animals. However, mechanism on cerebrum is still uncertain. Hence, a total 240 chickens were separated into four groups this study reveal potential connection between mitophagy and endoplasmic reticulum (ER) stress-mediated apoptosis chicken case excess exposure. The cu exposure situation was simulated by diets containing various levels (11 mg/kg, control group; 110 group I; 220 II 330 III) for 49 days. results histology showed that vacuolar degeneration observed treated groups, mitochondria swell autophagosomes formation found under treatment. Additionally, expression (PINK1, Parkin, LC3I, LC3II p62) ER stress (GRP78, PERK, ATF6, IRE1α, XBP1, CHOP, JNK) indexes significantly upregulated Furthermore, mRNA protein Bcl-2 decreased, while Bak1, Bax, Caspase12, Caspase3 increased compared group. In summary, demonstrated an overdose could induce cerebrum. These findings revealed important damage, provided new insight neurotoxicity.

Language: Английский

Mitochondrial Dysfunction and Parkinson’s Disease: Pathogenesis and Therapeutic Strategies DOI
Sadegh Moradi Vastegani, Ava Nasrolahi, Shahab Ghaderi

et al.

Neurochemical Research, Journal Year: 2023, Volume and Issue: 48(8), P. 2285 - 2308

Published: March 21, 2023

Language: Английский

Citations

47
AMPK/PPAR-γ/NF-κB axis participates in ROS-mediated apoptosis and autophagy caused by cadmium in pig liver DOI
Huan Wang, Anqi Wang, Xinqiao Wang

et al.

Environmental Pollution, Journal Year: 2021, Volume and Issue: 294, P. 118659 - 118659

Published: Dec. 8, 2021

Language: Английский

Citations

79
Endoplasmic Reticulum Stress Contributes to Copper-Induced Pyroptosis via Regulating the IRE1α-XBP1 Pathway in Pig Jejunal Epithelial Cells DOI
Jianzhao Liao,

Zhuoying Hu,

Quanwei Li

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2022, Volume and Issue: 70(4), P. 1293 - 1303

Published: Jan. 25, 2022

Copper (Cu) is a common additive in food products, which poses potential concern to animal and human health when it excess. Here, we investigated the relationship between endoplasmic reticulum (ER) stress pyroptosis Cu-induced toxicity of jejunum vivo vitro. In experiments, excess intake dietary Cu caused ER cavity expansion, elevated fluorescence signals GRP78 Caspase-1, increased mRNA protein expression levels related pig jejunal epithelium. Simultaneously, similar effects were observed IPEC-J2 cells under treatment. Importantly, 4-phenylbutyric acid (ER inhibitor) MKC-3946 (IRE1α significantly inhibited stress-triggered IRE1α-XBP1 pathway, also alleviated cells. general, these results suggested that participated regulating epithelial via provided novel view into toxicology Cu.

Language: Английский

Citations

51
mTOR in programmed cell death and its therapeutic implications DOI Creative Commons

Yawen Xie,

Xianli Lei,

Guoyu Zhao

et al.

Cytokine & Growth Factor Reviews, Journal Year: 2023, Volume and Issue: 71-72, P. 66 - 81

Published: June 1, 2023

Mechanistic target of rapamycin (mTOR), a highly conserved serine/threonine kinase, is involved in cellular metabolism, protein synthesis, and cell death. Programmed death (PCD) assists eliminating aging, damaged, or neoplastic cells, indispensable for sustaining normal growth, fighting pathogenic microorganisms, maintaining body homeostasis. mTOR has crucial functions the intricate signaling pathway network multiple forms PCD. can inhibit autophagy, which part PCD regulation. Cell survival affected by through autophagy to control reactive oxygen species production degradation pertinent proteins. Additionally, regulate an autophagy-independent manner affecting expression levels related genes phosphorylating Therefore, acts both autophagy-dependent -independent pathways It conceivable that exerts bidirectional regulation PCD, such as ferroptosis, according complexity networks, but underlying mechanisms have not been fully explained. This review summarizes recent advances understanding mTOR-mediated regulatory Rigorous investigations into PCD-related provided prospective therapeutic targets may be clinically beneficial treating various diseases.

Language: Английский

Citations

35
Bacillus coagulans (Weizmannia coagulans) XY2 attenuates Cu-induced oxidative stress via DAF-16/FoxO and SKN-1/Nrf2 pathways and gut microbiota regulation DOI
Yufang Gao, Ting Yu,

Yalan Wu

et al.

Journal of Hazardous Materials, Journal Year: 2023, Volume and Issue: 457, P. 131741 - 131741

Published: June 1, 2023

Language: Английский

Citations

25
Copper exposure induces inflammation and PANoptosis through the TLR4/NF-κB signaling pathway, leading to testicular damage and impaired spermatogenesis in Wilson disease DOI

Dan Zhao,

Limin Wu,

Xinru Fang

et al.

Chemico-Biological Interactions, Journal Year: 2024, Volume and Issue: 396, P. 111060 - 111060

Published: May 17, 2024

Language: Английский

Citations

9
Preliminary Structural Characterization of Selenium Nanoparticle Composites Modified by Astragalus Polysaccharide and the Cytotoxicity Mechanism on Liver Cancer Cells DOI Creative Commons
Haiyu Ji, Xiaowei Lou,

Jian-shuang Jiao

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(4), P. 1561 - 1561

Published: Feb. 6, 2023

Astragalus alcohol soluble polysaccharide (AASP) could present superior water solubility and antitumor activity with high concentration. Selenium nanoparticles (SeNPs) have received growing attention in various fields, but their unstable property increases the application difficulties. In study, functionalized nano-composites (AASP−SeNPs) were synthesized through SeNPs using AASP (average molecular weight of 2.1 × 103 Da) as a surface modifier, preliminary structural characteristics inhibitory mechanism on liver cancer (HepG2) cells investigated. Results showed that AASP−SeNPs prepared under sodium selenite/AASP mass ratio 1/20 (w/w) uniformly spherical mean grain size 49.80 nm exhibited dispersivity stability solution. Moreover, composites dose-dependently inhibit HepG2 cell proliferation induce apoptosis effectively regulating mitochondria-relevant indicators including ΔΨm depletion stimulation, intracellular ROS accumulation, Bax/Bcl-2 improvement, Cytochrome c liberation promotion. These results provide scientific references for future applications functional food drug industries.

Language: Английский

Citations

20
Cu exposure induces liver inflammation via regulating gut microbiota/LPS/liver TLR4 signaling axis DOI Creative Commons
Tiantian Gu, Minghua Kong,

Mingcai Duan

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 278, P. 116430 - 116430

Published: May 7, 2024

Copper (Cu) serves as an essential cofactor in all organisms, yet excessive Cu exposure is widely recognized for its role inducing liver inflammation. However, the precise mechanism by which triggers inflammation ducks, particularly relation to interplay gut microbiota regulation, has remained elusive. In this investigation, we sought elucidate impact of on through gut-liver axis ducks. Our findings revealed that markedly elevated AST and ALT levels induced upregulating pro-inflammatory cytokines (IL-1β, IL-6 TNF-α) triggering LPS/TLR4/NF-κB signaling pathway. Simultaneously, alterations composition intestinal flora communities, notably increasing relative abundance Sphingobacterium, Campylobacter, Acinetobacter reducing Lactobacillus. significantly decreased protein expression related barrier (Occludin, Claudin-1 ZO-1) promoted secretion cytokines. Furthermore, correlation analysis was observed microbiome were closely Fecal transplantation (FMT) experiments further demonstrated microbiota-depleted ducks transplanting fecal samples from Cu-exposed disturbed dysfunction, lead impaire function activate study provided insights into regulation axis. These results enhanced our comprehension potential mechanisms driving Cu-induced hepatotoxicity avian species.

Language: Английский

Citations

8
Gut microbiota disturbance exaggerates battery wastewater-induced hepatotoxicity through a gut-liver axis DOI
Jianzhao Liao, Yingwei Liu, Jiangnan Yi

et al.

The Science of The Total Environment, Journal Year: 2021, Volume and Issue: 809, P. 152188 - 152188

Published: Dec. 4, 2021

Language: Английский

Citations

39
Latent Benefits and Toxicity Risks Transmission Chain of High Dietary Copper along the Livestock–Environment–Plant–Human Health Axis and Microbial Homeostasis: A Review DOI
Yongkang Zhen,

Ling Ge,

Qiaoqing Chen

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2022, Volume and Issue: 70(23), P. 6943 - 6962

Published: June 6, 2022

The extensive use of high-concentration copper (Cu) in feed additives, fertilizers, pesticides, and nanoparticles (NPs) inevitably causes significant pollution the ecological environment. This type chain begins with animal husbandry: first, Cu accumulation animals poisons them; second, high enters soil water sources feces urine to cause toxicity, which may further lead crop plant pollution; third, this process ultimately endangers human health through consumption livestock products, aquatic foods, plants, even drinking water. High potentially alters antibiotic resistance aggravates disease risks. Thus, it is necessary formulate reasonable emission regulations because benefits for plants cannot be ignored. present review evaluates potential hazards livestock, environment, industry, health. We also discuss aspects related bacterial fungal homeostasis perspectives on application Cu–NPs microbial high-Cu removal technology reduce spread toxicity risks humans.

Language: Английский

Citations

24