Frontiers in Microbiology,
Journal Year:
2022,
Volume and Issue:
13
Published: May 3, 2022
Heavy
metal
resistant
bacteria
play
an
important
role
in
the
biogeochemical
cycle
soil,
but
benefits
of
microbial
oxidation
for
plants
and
soil
have
not
been
well-documented.
The
purpose
this
study
was
to
explore
contribution
two
Bacillus
spp.
alleviate
antimony
(Sb)
toxicity
plants,
and,
then,
propose
a
bioremediation
method
Sb
contaminated
which
is
characterized
by
environmental
protection,
high
efficiency,
low
cost.
This
explored
effects
cereus
HM5
thuringiensis
HM7
inoculation
on
Broussonetia
papyrifera
were
evaluated
under
controlled
stressed
conditions
(0
100
mmol/L,
slag)
through
pot
experiment.
results
show
that
total
root
length,
volume,
tips,
forks,
crossings,
activities
B.
with
are
higher
than
those
control
group,
strains
promote
plant
absorption
from
environment.
Especially
slag
treatment
had
most
significant
effect
promotion
promoting
papyrifera.
Compared
increased
64.54,
70.06,
70.04,
78.15,
97.73,
12.95%,
respectively.
root,
stem,
leaf
265.12,
250.00,
211.54%,
compared
Besides,
both
reduce
content
malondialdehyde,
proline,
soluble
sugars
leaves,
keeping
antioxidant
enzyme
activity
at
level,
alleviating
lipid
peroxidation.
Principal
component
analysis
(PCA)
shows
beneficial
maintenance
functions
improvement
environment,
thereby
Sb.
Therefore,
phytoremediation
promising
inoculant
used
bacteria-assisted
sites.
International Journal of Nanomedicine,
Journal Year:
2023,
Volume and Issue:
Volume 18, P. 3157 - 3176
Published: June 1, 2023
Introduction:
The
potential
effects
of
selenium
nanoparticles
(SeNPs)
administration
on
arsenic
exposure-mediated
nephrotoxicity
by
alleviating
fibrosis,
inflammation,
oxidative
stress-related
damage,
and
apoptosis
remains
more
detailed
investigations.
Methods:
After
the
synthesis
sodium
selenite
(Na
2
SeO
3
)
through
a
versatile
green
procedure,
biosafety
SeNPs
was
assessed
assaying
renal
functions
inflammation
in
mice.
Subsequently,
nephroprotective
against
arsenite
(NaAsO
)-induced
damages
were
confirmed
biochemical,
molecular,
histopathological
assays,
including
function,
histological
lesion,
mice
tissues
tubular
duct
epithelial
cells
(HK2
cells).
Results:
excellent
biocompatibility
safety
prepared
this
study
non-significant
differences
levels
between
negative
control
(NC)
1
mg/kg
groups
(p>
0.05).
results
assays
that
daily
for
4
weeks
not
only
ameliorated
dysfunctions
injuries
caused
NaAsO
exposure
but
also
inhibited
-exposed
In
addition,
altered
viability,
HK2
effectively
reversed
after
100
μg/mL
supplementation.
Conclusion:
Our
findings
authentically
exposure-induced
apoptosis.
Keywords:
nanoparticles,
arsenite,
nephroprotective,
stress,
Journal of Biochemical and Molecular Toxicology,
Journal Year:
2025,
Volume and Issue:
39(2)
Published: Feb. 1, 2025
ABSTRACT
This
systematic
review
and
meta‐analysis
aimed
to
evaluate
summarize
the
therapeutic
effects
of
naringin
on
various
kidney
diseases,
based
preclinical
research.
A
comprehensive
literature
search
was
performed
using
electronic
databases
such
as
PubMed/Medline
Google
Scholar,
concentrating
impact
in
different
experimental
animal
models
disease.
After
applying
inclusion
exclusion
criteria,
27
studies
were
chosen
for
analysis.
The
revealed
that
treatment
significantly
improved
body
weight
gain
markers
function,
evidenced
by
decreased
serum
urea,
creatinine,
blood
urea
nitrogen
(BUN)
levels.
Additionally,
normalized
antioxidant
parameters,
restored
enzymes
like
superoxide
dismutase
catalase,
alleviated
oxidative
stress
markers,
comprising
myeloperoxidase
reactive
oxygen
species.
Besides,
also
inflammation
indicated
reduced
levels
NF‐κB,
IL‐6,
KIM‐1,
COX‐2,
TNF‐α.
Furthermore,
it
regulated
apoptosis
decreasing
Bax,
caspase‐3,
p53
while
increasing
Bcl‐2.
In
summary,
demonstrated
mitigates
nephrotoxicity
induced
stress,
chemotherapy,
drugs,
chemicals.
nephroprotective
effect
is
mediated
through
a
combination
several
mechanisms,
including
antioxidant,
anti‐inflammatory,
anti‐apoptotic
pathways.
These
cellular
molecular
improvements
associated
with
enhanced
structure,
overall
physiology
following
treatment.
Overall,
this
provide
strong
scientific
evidence
supporting
potential
managing
diseases.
Journal of Agricultural and Food Chemistry,
Journal Year:
2023,
Volume and Issue:
71(42), P. 15809 - 15820
Published: Oct. 16, 2023
Groundwater
resources
are
often
contaminated
by
arsenic,
which
poses
a
serious
threat
to
human
and
animal's
health.
Some
studies
have
demonstrated
that
acute
arsenic
exposure
could
induce
kidney
injury
because
the
is
key
target
organ
for
toxicity,
but
exact
mechanism
remains
unclear.
Hence,
we
investigated
effect
of
SIRT1-/PINK1-mediated
mitophagy
on
NaAsO2-induced
in
vivo
vitro.
In
our
study,
NaAsO2
obviously
induced
renal
tubule
mitochondrial
dysfunction.
Meanwhile,
inhibit
mRNA/protein
level
SIRT1
activate
mitophagy-related
levels
mice.
HK-2
cells,
also
confirmed
nephrotoxicity
depended
activation
mitophagy.
Moreover,
resveratrol
alleviated
via
Interestingly,
inhibition
cyclosporin
A
(CsA)
further
exacerbated
inflammation
cells.
Taken
together,
study
found
SIRT1-regulated
PINK1-/Parkin-dependent
was
implicated
injury.
addition,
played
protective
role
against
Therefore,
may
represent
novel
therapeutic
prevention
treatment
