Transcriptome-based exploration of potential molecular targets and mechanisms of selenomethionine in alleviating renal ischemia–reperfusion injury DOI Creative Commons
Jun Pei, Xiao-Mao Tian, Chengjun Yu

et al.

Clinical Science, Journal Year: 2023, Volume and Issue: 137(18), P. 1477 - 1498

Published: Sept. 1, 2023

Renal ischemia-reperfusion injuries (IRIs) are one of the leading causes acute kidney (AKIs). Selenium, as an essential trace element, is able to antioxidant stress and reduces inflammatory responses. The regulation mechanism selenomethionine, major forms selenium intake by humans, not yet clear in renal IRIs. Therefore, we aimed explore key targets related mechanisms selenomethionine IRIs provide new ideas for treatment with We used transcriptome sequencing data from public databases well animal experiments target genes regulated IRI. found that can effectively alleviate IRI a may be achieved inhibiting MAPK signaling pathway. Meanwhile, also might selenoprotein GPX3 based on PPI protein interaction network machine learning. Through comprehensive analysis bioinformatic techniques experiments, Gpx3 serve gene Selenomethionine exert protective effect against up-regulating GPX3, pathway, increased production antioxidants, decreasing inflammation levels, mitigation apoptosis tubular epithelial cells, this histopathological damage protects function. Providing theoretical basis actions

Language: Английский

Disentangling the role of selenium in antagonizing the toxicity of arsenic and cadmium DOI
Iwona Zwolak

Archives of Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 8, 2025

Language: Английский

Citations

1
Synthesis and Application of Selenium Nanoparticles for the Modulation of Inflammatory Diseases DOI Creative Commons
Xueli Bai, Tianfei Zhou, Xiaowen Wu

et al.

Nano Biomedicine and Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

1
Customizable Zr-MOF nanoantidote-based multieffective arsenic detoxification and its extended low-toxic therapy DOI

Yanhua Zhong,

Wei Zhang,

Hong Xiao

et al.

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 182, P. 228 - 244

Published: May 16, 2024

Language: Английский

Citations

3
Antidiabetic potential of Selenium nanoparticles and plasma-rich platelets in diabetic mice DOI Creative Commons

Rania A. Karas,

Shaimaa M. I. Alexeree,

Nora Elzohery

et al.

Applied Biological Chemistry, Journal Year: 2024, Volume and Issue: 67(1)

Published: July 10, 2024

Abstract Diabetes mellitus is a widespread endocrine disorder, which categorized as the fourth leading cause of global mortality. Allopathic medicine has yet to provide satisfactory cure for this condition. Consequently, there an urgent demand innovative antidiabetic treatment approaches with enhanced management and minimum side effects costs. The study investigated synergistic potential combining selenium nanoparticles (Se NPs) plasma-rich platelets (PRP) in diabetic mice. Antidiabetic activity proposed combination NPs PRP) was evaluated from histopathological biochemical perspectives. experiment involved alloxan monohydrate induced mouse model. In vivo study, several parameters assessing effect novel were performed such blood glucose levels, body weight, lipid profiles, liver damage markers (AST ALT). Scavenging antioxidant assessed by evaluation levels hepatic renal GSH, MDA, SOD, CAT activities. Complete examinations vital internal organs carried out. Results revealed that Se PRP presents approach better diabetes reduced complications associated disease. These findings have therapeutic implications managing mellitus.

Language: Английский

Citations

3
Gallic acid-selenium nanoparticles with dual anti-inflammatory and antioxidant functions for synergistic treatment of acute kidney injury DOI
Jie Zhou,

Min Guan,

Huili Ma

et al.

Nanomedicine Nanotechnology Biology and Medicine, Journal Year: 2024, Volume and Issue: 62, P. 102775 - 102775

Published: Aug. 6, 2024

Language: Английский

Citations

3
Protective Effects of Lactoferrin Treatment Against Sodium Arsenite Exposure-Induced Nephrotoxicity DOI

Shubin Li,

Yu-Qing Yin,

Xingna Dong

et al.

Biological Trace Element Research, Journal Year: 2024, Volume and Issue: unknown

Published: June 4, 2024

Language: Английский

Citations

2
Advances in nephroprotection: the therapeutic role of selenium, silver, and gold nanoparticles in renal health DOI

Karthik K Karunakar,

Elizabeth Rani Edwin,

Meenaloshini Gopalakrishnan

et al.

International Urology and Nephrology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 23, 2024

Language: Английский

Citations

2
Regulation of Fuzheng Huayu capsule on inhibiting the fibrosis-associated hepatocellular carcinogenesis DOI
Wenqi Zhang, Jiaxin Sun, Shuting Lan

et al.

Journal of Asian Natural Products Research, Journal Year: 2024, Volume and Issue: 26(10), P. 1219 - 1238

Published: May 23, 2024

In the current study, bioinformatics analysis of hepatocellular carcinoma (HCC) dataset was conducted with hepatoprotective effect Fuzheng Huayu (FZHY) capsule against diethylnitrosamine-induced HCC progression analyzed. Eight cell clusters were defined and tanshinone IIA, arachidonic acid, quercetin, compounds FZHY capsule, inhibit progression-related fibrosis by regulating expression PLAU IGFBP3. Combined ameliorative liver dysfunctions IGFBP3, our study confirmed on inhibiting fibrosis-associated via

Language: Английский

Citations

1
Effect of Gentianella acuta (Michx.) Hulten against the arsenic-induced development hindrance of mouse oocytes DOI
Chunyu Wang, Biao Wang, Ying Wei

et al.

BioMetals, Journal Year: 2024, Volume and Issue: 37(6), P. 1411 - 1430

Published: May 30, 2024

Language: Английский

Citations

1
Transcriptome-based exploration of potential molecular targets and mechanisms of selenomethionine in alleviating renal ischemia–reperfusion injury DOI Creative Commons
Jun Pei, Xiao-Mao Tian, Chengjun Yu

et al.

Clinical Science, Journal Year: 2023, Volume and Issue: 137(18), P. 1477 - 1498

Published: Sept. 1, 2023

Renal ischemia-reperfusion injuries (IRIs) are one of the leading causes acute kidney (AKIs). Selenium, as an essential trace element, is able to antioxidant stress and reduces inflammatory responses. The regulation mechanism selenomethionine, major forms selenium intake by humans, not yet clear in renal IRIs. Therefore, we aimed explore key targets related mechanisms selenomethionine IRIs provide new ideas for treatment with We used transcriptome sequencing data from public databases well animal experiments target genes regulated IRI. found that can effectively alleviate IRI a may be achieved inhibiting MAPK signaling pathway. Meanwhile, also might selenoprotein GPX3 based on PPI protein interaction network machine learning. Through comprehensive analysis bioinformatic techniques experiments, Gpx3 serve gene Selenomethionine exert protective effect against up-regulating GPX3, pathway, increased production antioxidants, decreasing inflammation levels, mitigation apoptosis tubular epithelial cells, this histopathological damage protects function. Providing theoretical basis actions

Language: Английский

Citations

3