Sex-specific associations of urinary metals with renal function: A cross-sectional study in China DOI Creative Commons

Yinxia Lin,

Jiansheng Cai, Qiumei Liu

et al.

Research Square (Research Square), Journal Year: 2022, Volume and Issue: unknown

Published: May 9, 2022

Abstract Background: Extensive studies revealed the association between heavy metals and CKD. Compared with single meta, mixtures reflect exposure scenarios in real life deserves attention. While mechanism of action metal mixture on renal function is still undefined. Methods: A cross-sectional study involving 2775 participants was conducted. Urinary concentrations were measured by inductively coupled plasma mass spectrometry, estimated glomerular filtration rate (eGFR) for calculated. The eGFR linear regression. Interaction used to evaluate using a Bayesian nuclear machine regression model (BKMR). Results: In regression, urinary As (β = 2.723, P<0.05) Pb 3.081, positively correlated total population. BKMR model, five had positive joint effect levels, (PIP 0.996) contributed most levels. significantly associated levels women. displayed significant when all other fixed at 25th, 50th, 75th percentiles. Conclusions: To best our knowledge All mixed eGFR, while demonstrated more important effects than four mixture, especially

Language: Английский

Association between multiple-heavy-metal exposures and systemic immune inflammation in a middle-aged and elderly Chinese general population DOI Creative Commons
Linhai Zhao, Yanfei Wei, Qiumei Liu

et al.

BMC Public Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: April 29, 2024

Exposure to heavy metals alone or in combination can promote systemic inflammation. The aim of this study was investigate potential associations between multiple plasma and markers immune

Language: Английский

Citations

7
Association Between Urinary Metal Levels and Chronic Kidney Dysfunction in Rural China: A Study on Sex-Specific Differences DOI Creative Commons

K Teng,

Qinyi Guan, Qiumei Liu

et al.

Toxics, Journal Year: 2025, Volume and Issue: 13(1), P. 55 - 55

Published: Jan. 14, 2025

Background: While current epidemiological studies have documented associations between environmental metals and renal dysfunction, the majority concentrated on plasma metal levels. The relationship urinary exposure chronic kidney disease (CKD) remains contentious, particularly within specific demographic groups. Methods: This cross-sectional study included 2919 rural Chinese adults recruited 2018 2019. Urine were measured by ICP-MS. Least absolute shrinkage selection operator (LASSO) regression was employed to identify significantly associated with CKD. Then, we used binary logistic regression, along restricted cubic spline (RCS) models, assess individual effects of Quantile g-computation, weighted quantile sum Bayesian kernel machine (BKMR) models applied evaluate combined exposures Gender-stratified analyses also conducted explore these associations. Results: LASSO identified seven (V, Cu, Rb, Sr, Ba, W, Pb) significant impacts In single-metal Cu W exhibited a positive correlation CKD, whereas V, Pb showed negative correlations (all p < 0.05). RCS analysis revealed nonlinear Pb, CKD p-nonlinear multi-metal model, quantile-based g-computation demonstrated collective association risk for mixed (OR (95% CI) = −0.430 (−0.656, −0.204); 0.001), contributing this effect. WQS model further confirmed joint CI): −0.885 (−1.083, −0.899); V as main contributor. BKMR indicated an overall impact mixture risk. Interactions may exist well Sr Pb. female subgroup in consistency association. Conclusions: Our findings demonstrate risk, notable females. Joint multiple involve synergistic or antagonistic interactions influencing function. Further research is needed validate observations elucidate underlying mechanisms.

Language: Английский

Citations

0
Role of Glucose Metabolism in the Effects of Serum Metals on Telomere Length: Findings in Chinese Diabetic Population DOI

Shuren Ding,

Qian Gu,

Zhiqiang Zhao

et al.

Biological Trace Element Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

Language: Английский

Citations

0
Development of a novel strategy for the determination of Ag(I), Cu(II) and Ni(II) in urine after the extraction mediated by a semipermeable membrane DOI

Karoline Dutra do Amaral,

Pamela S. M. Rocha,

André S. Araújo

et al.

Journal of Pharmaceutical and Biomedical Analysis, Journal Year: 2025, Volume and Issue: unknown, P. 116837 - 116837

Published: March 1, 2025

Language: Английский

Citations

0
Single and Combined Associations of Plasma and Urine Essential Trace Elements (Zn, Cu, Se, and Mn) with Cardiovascular Risk Factors in a Mediterranean Population DOI Creative Commons
Rocío Barragán, Cristina Sánchez‐González, Pilar Aranda

et al.

Antioxidants, Journal Year: 2022, Volume and Issue: 11(10), P. 1991 - 1991

Published: Oct. 7, 2022

Trace elements are micronutrients that required in very small quantities through diet but crucial for the prevention of acute and chronic diseases. Despite fact initial studies demonstrated inverse associations between some most important essential trace (Zn, Cu, Se, Mn) cardiovascular disease, several recent have reported a direct association with risk factors due to these can act as both antioxidants pro-oxidants, depending on factors. This study aims investigate plasma urine concentrations general population from Mediterranean region, including 484 men women aged 18−80 years considering individually joint exposure. Zn, Mn were determined using an inductively coupled mass spectrometer (ICP-MS). Single combined analysis lipid, blood pressure, diabetes, anthropometric variables was undertaken. Principal component analysis, quantile-based g-computation, calculation element scores (TERS) used analyses. Models adjusted covariates. In single models, we found statistically significant Se increased total cholesterol systolic pressure; Cu triglycerides body index; Zn glucose. Moreover, exposure quantile g-computation TERS, levels (directly), (inversely) strongly associated hypercholesterolemia (OR: 2.03; 95%CI: 1.37−2.99; p < 0.001 per quartile increase approach). The mixtures revealed relationship fasting glucose diabetes 1.91; 1.01−3.04; = 0.046). conclusion, this population, effect higher (primarily Zn) directly elevated lipids, whereas mixture primarily Both parameters relevant factors, exposures should be considered caution.

Language: Английский

Citations

15
Association between Copper Exposure and Cognitive Function: A Cross-Sectional Study in a County, Guangxi, China DOI

Xia Xu,

Chunbao Mo, Jian G. Qin

et al.

Biological Trace Element Research, Journal Year: 2024, Volume and Issue: unknown

Published: July 5, 2024

Language: Английский

Citations

3
Urinary Levels of 14 Metal Elements in General Population: A Region-Based Exploratory Study in China DOI Creative Commons
Zining Zhang, Sai Guo,

Liting Hua

et al.

Toxics, Journal Year: 2023, Volume and Issue: 11(6), P. 488 - 488

Published: May 27, 2023

Metal pollution may lead to a variety of diseases; for this reason, it has become matter public concern worldwide. However, is necessary use biomonitoring approaches assess the risks posed human health by metals. In study, concentrations 14 metal elements in 181 urine samples obtained from general population Gansu Province, China, were analyzed using inductively coupled plasma mass spectrometry. Eleven out fourteen target had detection frequencies above 85%, namely, Cr, Ni, As, Se, Cd, Al, Fe, Cu and Rb. The most our subjects corresponded medium levels other regional studies. Gender exerted significant influence (p < 0.05) on Tl, Rb Zn. Pb, Sr, Zn, Se showed differences among different age groups age-related concentration trends varied these elements. There Zn Sr between those group who frequently exposed soil (exposed > 20 min/day) not, indicating that people regular contact with be more This study provides useful information evaluating exposure populations.

Language: Английский

Citations

7
Arsenic exposure incurs hyperglycemia mediated by oxidative damage in urban adult population: A prospective cohort study with three repeated measures DOI
Yongfang Zhang, Min Zhou,

Ruyi Liang

et al.

Environmental Research, Journal Year: 2023, Volume and Issue: 229, P. 116009 - 116009

Published: April 28, 2023

Language: Английский

Citations

6
The association between the essential metal mixture and fasting plasma glucose in Chinese community-dwelling elderly people DOI Creative Commons
Panpan Wang,

Jingyuan Lei,

Yuan Wang

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 263, P. 115289 - 115289

Published: July 25, 2023

Epidemiological studies about the effect of essential metal mixture on fasting plasma glucose (FPG) levels among elderly people are sparse. The object this study was to examine associations single metals and with FPG in Chinese community-dwelling people.The recruited 2348 total. Inductively coupled plasma-mass spectrometry adopted detect vanadium (V), selenium (Se), magnesium (Mg), cobalt (Co), calcium (Ca), molybdenum (Mo) urine. relationships between were evaluated by linear regression Bayesian kernel machine (BKMR) models, respectively.In multiple-metal urine V Mg negatively related (β = - 0.016, 95 % CI: 0.030 0.003 for V; β 0.021, 0.033 0.009 Mg), Se positively 0.024, 0.014-0.034). In BKMR model, significant also found. associated a dose-response pattern, had maximum posterior inclusion probability (PIP) value (PIP 1.0000), followed 0.9968). Besides, Co showed association decreased older adults without hyperlipemia women.Both levels, individually as mixture. displayed relationship reduced having largest contribution Se. Further prospective investigations necessary validate these exploratory findings.

Language: Английский

Citations

6
Exposure to multiple metals in adults and diabetes mellitus: a cross-sectional analysis DOI
Zhen Wu, Tong Guan, Dandan Cai

et al.

Environmental Geochemistry and Health, Journal Year: 2022, Volume and Issue: 45(6), P. 3251 - 3261

Published: Oct. 13, 2022

Language: Английский

Citations

9