Cited by Association between multiple metal exposure and bone mineral density among Chinese adults

Blood metal levels predict digestive tract cancer risk using machine learning in a U.S. cohort DOI

Chenyuan Shi,

Hanfeng Jiang,

Fangzhou Zhao

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 8, 2025

Background: Environmental metal exposure has been implicated in the development of digestive tract cancers, although specific associations remain poorly defined. This study aimed to investigate relationship between blood levels and risk cancers among U.S. adults. Methods: Data from National Health Nutrition Examination Survey (NHANES) 2011–2018, including 13,467 participants aged 20 years older, were analyzed. Nine metals measured. Multivariable logistic regression, restricted cubic spline models, subgroup analyses employed assess cancer risk. Additionally, a Random Forest (RF) model was used for prediction. Results: Among participants, 9 had esophagus (EC), 11 gastric (GC), 83 colorectal (CRC). Compared healthy controls, EC patients exhibited significantly higher potassium (K, 4.40 vs. 4.00 mmol/L), cadmium (Cd, 12.46 2.49 µg/L), lead (Pb, 0.09 0.05 µg/L). GC elevated Pb (0.08 while CRC showed concentrations Cd (3.11 µg/L) (0.06 0.04 Logistic regression analysis revealed significant K (odds ratio [OR] = 7.58, 95% CI: 3.48–16.48, P < 0.0001), (OR 1.06, 1.04–1.08, 7.60, 3.26–17.72, 0.0001) also associated with 5.26, 2.11–13.10, 0.001). The RF an accuracy 76% predicting risk, SHapley Additive exPlanations (SHAP) highlighting iron (Fe) as key contributors. Conclusions: reveals positive association certain suggesting that limiting these may serve potential preventive measure.

Language: Английский

Citations

Method validation for (ultra)-trace element concentrations in urine for small sample volumes in large epidemiological studies: application to the population-based epidemiological multi-ethnic study of atherosclerosis (MESA) DOI

Kathrin Schilling, Ronald A. Glabonjat,

Olgica Balac

et al.

Analytical Methods, Journal Year: 2023, Volume and Issue: 16(2), P. 214 - 226

Published: Dec. 4, 2023

Analysis of essential and non-essential trace elements in urine has emerged as a valuable tool for assessing occupational environmental exposures, diagnosing nutritional status guiding public health care intervention. Our study focused on the analysis samples from Multi-Ethnic Study Atherosclerosis (MESA), precious resource research with limited sample volumes. Here we provide comprehensive sensitive method 18 using only 100 μL urine. Method sensitivity, accuracy, precision were assessed. The by inductively coupled plasma mass spectrometry (ICP-MS) included measurement antimony (Sb), arsenic (As), barium (Ba), cadmium (Cd), cesium (Cs), cobalt (Co), copper (Cu), gadolinium (Gd), lead (Pb), manganese (Mn), molybdenum (Mo), nickel (Ni), selenium (Se), strontium (Sr), thallium (Tl), tungsten (W), uranium (U), zinc (Zn). Further, reported urinary element concentrations covariates including gender, ethnicity/race, smoking location. results showed good accuracy sensitivity ICP-MS limit detections rangings between 0.001 μg L

Language: Английский

Citations

Electrochemical Filtration of Gadolinium from Patient Urine after Magnetic Resonance Imaging DOI

Sethma Wijesinghe,

Udeshika Weerarathna,

Christa Kovaci

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 20, 2025

The widespread use of gadolinium-based contrast agents for magnetic resonance imaging (MRI) in recent decades has led to a growing demand Gd and raised environmental concerns due their direct discharge into wastewater systems. In response, we developed an electrochemical filtration method recover from patient urine following contrast-enhanced MRI. This involves modifying conventional vacuum apparatus by introducing electrodes the filter membrane, creating strong electric field ∼5 kV/m steep three-zone pH gradient within membrane. These fields facilitate dissociation Gd-based agents, releasing GdIII ions, electrophoretic separation its ligand, eventually precipitation trapping as GdPO4 Gd(OH)3 on Using gadopentetate dimeglumine (GdDTPA) model agent, achieved efficiency ∼70% artificial real samples. For macrocyclic such gadoterate meglumine (GdDOTA), decreased 25.4% slow kinetics agents. However, can be improved ∼40% allowing agent predissociate acidic environment before filtration. trapped membrane recovered thermal treatment muffle furnace. After treatment, reclaimed sample was primarily identified GdPO4. design offers straightforward practical approach recovering MRI scans, addressing increasing helping alleviate about contamination surface water.

Language: Английский

Citations

Association between urinary trace elements levels and depressive symptoms among the older population DOI

Ying Zhang, Junjiao Ping, Dong Cui

et al.

Experimental Gerontology, Journal Year: 2025, Volume and Issue: 202, P. 112709 - 112709

Published: Feb. 13, 2025

Late-life depression is a prevalent public health issue among the elderly. Imbalances in trace elements are increasingly recognized as associated with depression; however, majority of current research has concentrated on examining link between blood-based levels and depressive symptoms. Our objective was to determine if similar correlation observed urinary We employed stratified, multi-stage random sampling recruit 400 participants, aged 60 years or older, from community-based population city located southern China. The Patient Health Questionnaire-9 Items (PHQ-9) utilized evaluate concentration urine detected by inductively coupled plasma mass spectrometry. Multiple logistic regression analysis conducted assess association symptoms, well interactions these potential covariates. Restricted Cubic Spline (RCS) model four knots further explore symptoms risk after adjusting for confounders. A total 391 participants were investigated, including 50 (12.6 %) symptom group 341 (87.4 non-depressive group. Urinary copper positively correlated Compared lowest tertile copper, multivariate adjusted odds ratios 2.58 (1.18-5.64) 3. Furthermore, we found gender p < 0.05. correction OR T3 versus T1 males 21.10 (1.79-248.13) (Pfor trend = 0.002). RCS revealed positive (P-overall 0.025, P-nonlinear 0.161). No significant difference developing individuals concentrations below 8.22 μg/g creatinine. However, increases progressively exceeds this threshold. development exposure men more sensitive non-invasive test, promising indicator environmental exposure.

Language: Английский

Citations

Impact of COVID-19 on Temporal Trends and Health Risks of Urinary Metal Concentrations among Residents of Guangzhou, China DOI

Jia Liao,

Rende Huang,

Xiangyu Jia

et al.

Environmental Research, Journal Year: 2024, Volume and Issue: 261, P. 119705 - 119705

Published: July 29, 2024

Language: Английский

Citations

Association of urinary metal element with semen quality: a cross-sectional study from Eastern China DOI

Shijie Geng,

Fengjuan Chang,

Junya Wang

et al.

Environmental Geochemistry and Health, Journal Year: 2024, Volume and Issue: 46(8)

Published: July 3, 2024

Language: Английский

Citations

Association between multiple metal exposure and bone mineral density among Chinese adults DOI

Gaojie Fan, Qing Liu, Mingyang Wu

et al.

Environmental Geochemistry and Health, Journal Year: 2024, Volume and Issue: 46(11)

Published: Oct. 14, 2024

Language: Английский

Citations