Frontiers in Immunology,
Journal Year:
2023,
Volume and Issue:
14
Published: Nov. 3, 2023
Sepsis
is
a
hyper-heterogeneous
syndrome
in
which
the
systemic
inflammatory
response
persists
throughout
course
of
disease
and
immune
responses
are
dynamically
altered
at
different
pathogenic
stages.
Gasdermins
(GSDMs)
proteins
pore-forming
executors
membrane,
subsequently
mediating
release
pro-inflammatory
mediators
cell
death.
With
increasing
research
on
GSDMs
sepsis,
it
believed
that
protein
one
most
promising
therapeutic
targets
sepsis
future.
A
more
comprehensive
in-depth
understanding
functions
important
to
alleviate
multi-organ
dysfunction
reduce
sepsis-induced
mortality.
In
this
review,
we
focus
function
proteins,
molecular
mechanism
involved
regulatory
GSDMs-mediated
signaling
pathways,
aiming
provide
novel
ideas
strategies
for
diagnosis
treatment
sepsis.
Cell Death Discovery,
Journal Year:
2024,
Volume and Issue:
10(1)
Published: Jan. 16, 2024
Abstract
Pyroptotic
cell
death,
an
inflammatory
form
of
programmed
death
(PCD),
is
emerging
as
a
potential
therapeutic
opportunity
for
radiotherapy
(RT).
RT
commonly
used
cancer
treatment,
but
its
effectiveness
can
be
limited
by
tumor
resistance
and
adverse
effects
on
healthy
tissues.
Pyroptosis,
characterized
swelling,
membrane
rupture,
release
pro-inflammatory
cytokines,
has
been
shown
to
enhance
the
immune
response
against
cells.
By
inducing
pyroptotic
in
cells,
treatment
outcomes
stimulating
anti-tumor
responses
improving
overall
efficacy
RT.
Furthermore,
danger
signals
from
cells
promote
recruitment
activation
leading
systemic
that
may
target
distant
metastases.
Although
further
research
needed
fully
understand
mechanisms
optimize
use
RT,
it
holds
promise
novel
strategy
outcomes.
This
review
aims
synthesize
recent
regulatory
underlying
radiation-induced
pyroptosis
elucidate
significance
this
process
The
insights
gained
analysis
inform
strategies
tumors.
European Journal of Pharmacology,
Journal Year:
2025,
Volume and Issue:
995, P. 177414 - 177414
Published: Feb. 20, 2025
Cell
death
occurs
continuously
throughout
individual
development.
By
removing
damaged
or
senescent
cells,
cell
not
only
facilitates
morphogenesis
during
the
developmental
process,
but
also
contributes
to
maintaining
homeostasis
after
birth.
In
addition,
reduces
spread
of
pathogens
by
eliminating
infected
cells.
is
categorized
into
two
main
forms:
necrosis
and
programmed
death.
Programmed
encompasses
several
types,
including
autophagy,
pyroptosis,
apoptosis,
necroptosis,
ferroptosis,
PANoptosis.
Autophagy,
a
mechanism
that
maintains
cellular
equilibrium
via
breakdown
reutilization
proteins
organelles,
implicated
in
regulating
almost
all
forms
pathological
contexts.
Notably,
PANoptosis
are
directly
classified
as
autophagy-mediated
Therefore,
autophagy
presents
therapeutic
approach
for
treating
diseases
such
inflammation
tumors
arise
from
abnormalities
other
This
review
focuses
on
crosstalk
between
modalities,
providing
new
perspectives
clinical
interventions
inflammatory
neoplastic
diseases.
Cell Division,
Journal Year:
2024,
Volume and Issue:
19(1)
Published: Aug. 3, 2024
Cell
death
is
one
of
the
most
important
mechanisms
maintaining
homeostasis
in
our
body.
Ferroptosis
and
pyroptosis
are
forms
necrosis-like
cell
death.
These
modalities
play
key
roles
pathophysiology
cancer,
cardiovascular,
neurological
diseases,
other
pathologies.
Transition
metals
abundant
group
elements
all
living
organisms.
This
paper
presents
a
summary
ferroptosis
pathways
their
connection
to
significant
transition
metals,
namely
zinc
(Zn),
copper
(Cu),
molybdenum
(Mo),
lead
(Pb),
cobalt
(Co),
iron
(Fe),
cadmium
(Cd),
nickel
(Ni),
mercury
(Hg),
uranium
(U),
platinum
(Pt),
crucial
element,
selenium
(Se).
Authors
aim
summarize
up-to-date
knowledge
this
topic.In
review,
there
categorized
highlighted
common
patterns
alterations
by
metals.
Special
attention
given
since
collected
data
support
its
dual
nature
action
both
pyroptosis.
All
findings
presented
together
with
brief
description
major
biochemical
involving
mentioned
visualized
attached
comprehensive
figures.This
work
concludes
that
majority
disruptions
studied
metals'
impacts
fate,
influencing
survival
cells
complex
system
altered
pathways.
Therefore,
opens
up
space
for
further
research.
Frontiers in Cell and Developmental Biology,
Journal Year:
2023,
Volume and Issue:
11
Published: Nov. 20, 2023
Acute
kidney
injury
(AKI)
induces
significant
energy
metabolic
reprogramming
in
renal
tubular
epithelial
cells
(TECs),
thereby
altering
lipid,
glucose,
and
amino
acid
metabolism.
The
changes
lipid
metabolism
encompass
not
only
the
downregulation
of
fatty
oxidation
(FAO)
but
also
cell
membrane
lipids
triglycerides
Regarding
glucose
metabolism,
AKI
leads
to
increased
glycolysis,
activation
pentose
phosphate
pathway
(PPP),
inhibition
gluconeogenesis,
upregulation
polyol
pathway.
Research
indicates
that
inhibiting
promoting
PPP,
blocking
exhibit
a
protective
effect
on
AKI-affected
kidneys.
Additionally,
including
branched-chain
acids,
glutamine,
arginine,
tryptophan,
play
an
important
role
progression.
These
are
closely
related
programmed
death
TECs,
involving
autophagy,
apoptosis,
necroptosis,
pyroptosis,
ferroptosis.
Notably,
abnormal
intracellular
accumulation
can
impede
autophagic
clearance,
further
exacerbating
compromising
function,
forming
vicious
cycle.
Recent
studies
have
demonstrated
potential
ameliorating
AKI-induced
damage
through
calorie
dietary
restriction.
Consequently,
modifying
TECs
patterns
may
be
effective
strategy
for
treatment.
