Novel insights into the regulatory role of N6-methyladenosine methylation modified autophagy in sepsis DOI Creative Commons

Cheng-Fei Bi,

Jia Liu, Xiao Hu

et al.

Aging, Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 18, 2023

Sepsis is defined as a life-threatening organ dysfunction caused by dysregulated host response to infection. It characterized high morbidity and mortality one of the major diseases that seriously hang over global human health. Autophagy crucial regulator in complicated pathophysiological processes sepsis. The activation autophagy known be great significance for protecting sepsis induced dysfunction. Recent research has demonstrated N6-methyladenosine (m6A) methylation well-known post-transcriptional RNA modification controls epigenetic gene expression well number biological In addition, m6A affects stability, export, splicing translation transcripts involved autophagic process. Although it been suggested regulates metabolic more frequently seen progression pathogenesis, underlying molecular mechanisms m6A-modified have not thoroughly elucidated. present article fills this gap providing an review its potential role development novel therapeutics.

Language: Английский

Neurotoxic effects of heavy metal pollutants in the environment: Focusing on epigenetic mechanisms DOI
Guangxia Yu,

Lingyan Wu,

Qianqian Su

et al.

Environmental Pollution, Journal Year: 2024, Volume and Issue: 345, P. 123563 - 123563

Published: Feb. 13, 2024

Language: Английский

Citations

26
RNA methylation modifications in neurodegenerative diseases: Focus on their enzyme system DOI Creative Commons
Lu Liu, Yujia Zhao, Feng Zhang

et al.

Journal of Advanced Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Neurodegenerative diseases (NDs) constitute a significant public health challenge, as they are increasingly contributing to global mortality and morbidity, particularly among the elderly population. Pathogenesis of NDs is intricate multifactorial. Recently, post-transcriptional modifications (PTMs) RNA, with particular focus on mRNA methylation, have been gaining increasing attention. At present, several regulatory genes associated methylation identified closely neurodegenerative disorders. This review aimed summarize RNA enzymes system, including writer, reader, eraser proteins delve into their functions in central nervous system (CNS), hoping open new avenues for exploring mechanisms therapeutic strategies NDs. studies highlighted critical role development function CNS, abnormalities this process may contribute brain damage NDs, aberrant expression involved has implicated onset

Language: Английский

Citations

1
N6-methyladenosine demethylase ALKBH5 homologous protein protects against cerebral I/R injury though suppressing SNHG3-mediated neural PANoptosis: Involvement of m6A-related macromolecules in the diseases of nervous system DOI

Yuda Qiu,

Yafei Fan, Gang Huang

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 274, P. 133815 - 133815

Published: July 10, 2024

Language: Английский

Citations

5
Emerging Roles for DNA 6mA and RNA m6A Methylation in Mammalian Genome DOI Open Access

Leijie Xie,

Xiaosong Zhang,

Jiaxiang Xie

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(18), P. 13897 - 13897

Published: Sept. 9, 2023

Epigenetic methylation has been shown to play an important role in transcriptional regulation and disease pathogenesis. Recent advancements detection techniques have identified DNA N6-methyldeoxyadenosine (6mA) RNA N6-methyladenosine (m6A) as modifications at the sixth position of adenine RNA, respectively. While distributions functions 6mA m6A extensively studied prokaryotes, their roles mammalian brain, where they are enriched, still not fully understood. In this review, we provide a comprehensive summary current research progress on m6A, well associated writers, erasers, readers both levels. Specifically, focus potential fundamental biological pathways genome highlight significant regulatory neurodegenerative diseases.

Language: Английский

Citations

12
Targeting m6A mRNA demethylase FTO alleviates manganese-induced cognitive memory deficits in mice DOI
Yi Wen,

Zhushan Fu,

Jiashuo Li

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 476, P. 134969 - 134969

Published: June 18, 2024

Language: Английский

Citations

4
ALKBH5-mediated N6-methyladenosine modification of HO-1 mRNA regulates ferroptosis in cobalt-induced neurodegenerative damage DOI Creative Commons
Qianqian Su, Lingyan Wu, Chunyan Zheng

et al.

Environment International, Journal Year: 2024, Volume and Issue: 190, P. 108897 - 108897

Published: July 20, 2024

The utilization of Cobalt (Co) has surged due to it is critical role in renewable energy technologies and other high-tech applications. Concurrently, the potential health risks associated with Co exposure have raised concerns. Previous studies, including our own, shown that can impair learn memory functions as an epigenetic hazard, even at low concentrations. In this study, we explore mechanisms Co-induced ferroptosis neurodegenerative damage both vivo vitro, focusing on regulation by N6-methyladenosine (m

Language: Английский

Citations

3
ALKBH5 deficiency attenuates oxygen-glucose deprivation-induced injury in mouse brain microvascular endothelial cells in an m6A dependent manner DOI Creative Commons
Xiufang Jiang, Yan Feng,

Yanan Geng

et al.

Experimental Neurology, Journal Year: 2024, Volume and Issue: 380, P. 114910 - 114910

Published: Aug. 3, 2024

Structural and functional alterations in brain microvascular endothelial cells (BMECs) caused by oxygen-glucose deprivation (OGD) are involved the pathogenesis of various disorders. AlkB homolog 5 (ALKBH5) is a primary m6A demethylase that regulates cell processes, but its distinct roles BMEC function remain to be clarified. In present study, mouse middle cerebral artery occlusion (MCAO) model, knockout ALKBH5 reduced neurological deficits, infarct volumes tissue apoptosis ischemia/reperfusion injury. Evans blue leakage decreased expression tight junction protein ZO-1 Occludin were also attenuated knockout. During exploration underlying mechanisms role BMECs, we found was induced at both mRNA levels hypoxia; however, stability impaired OGD treatment. Knockdown increased total alleviated OGD-induced At same time, selective inhibitor Cpd 20m exhibited protective effect on contrast, overexpression sensitivity BMECs OGD. Interestingly, sequencing data revealed knockdown ALKBH5altered many genes via upregulation. The gene verified real-time PCR. Taken together, our results suggest ALKBH5, as well target genes, plays important regulation through RNA activity.

Language: Английский

Citations

2
RNA m6A Methylation and Alzheimer's Disease: Current Evidence and Future Perspectives DOI Creative Commons

Wenqi Pan,

Yan Chen,

Yuesi Xu

et al.

Human Brain, Journal Year: 2024, Volume and Issue: 3(1)

Published: March 15, 2024

Background: Alzheimer’s disease (AD) is the most common neurodegenerative characterized by pathological accumulation of b-amyloid and neurofibrillary tangles. Despite substantial progress in both basic clinical research on AD, detailed mechanism AD pathogenesis still elusive. RNA N6-methyladenosine methylation (m6A) predominant post-transcriptional modification eukaryotic mRNA, prominently enriched mammalian brain. Notably, m6A-modified showed significant changes during development indicating an important role this pathogenesis. Aim: In study, we aim to provide a summary recent advances highlighting indispensable m6A Result: From perspective modification, review our current understanding association between machinery risk factors as well its involvement various pathophysiological hallmarks AD. We also discuss main obstacles studies about corresponding caveats solutions them. Conclusion: This emphasizes significance investigating context highlights considerable potential for emerge novel therapeutic target

Language: Английский

Citations

2
Epigenetic targeting of autophagy for cancer: DNA and RNA methylation DOI Creative Commons

Luobin Lin,

Yun‐Tao Zhao, Qinzhou Zheng

et al.

Frontiers in Oncology, Journal Year: 2023, Volume and Issue: 13

Published: Dec. 8, 2023

Autophagy, a crucial cellular mechanism responsible for degradation and recycling of intracellular components, is modulated by an intricate network molecular signals. Its paradoxical involvement in oncogenesis, acting as both tumor suppressor promoter, has been underscored recent studies. Central to this regulatory are the epigenetic modifications DNA RNA methylation, notably presence N6-methyldeoxyadenosine (6mA) genomic N6-methyladenosine (m6A) eukaryotic mRNA. The 6mA modification adds extra dimension regulation, potentially impacting transcriptional dynamics genes linked autophagy and, especially, cancer. Conversely, m6A modification, governed methyltransferases demethylases, influences mRNA stability, processing, translation, affecting central autophagic pathways. As we delve deeper into complexities importance these methylation grows more evident. interplay 6mA, m6A, points layered mechanism, illuminating reactions range conditions. This review delves nexus between their influence on cancer contexts. By closely examining markers, underscore promise therapeutic avenues, suggesting novel approaches intervention through modulation.

Language: Английский

Citations

4
Recent advances in the interplay between stress granules and m6A RNA modification DOI

Lijuan Sun,

Z. Zuo,

Xiaokui Qiu

et al.

Current Opinion in Solid State and Materials Science, Journal Year: 2023, Volume and Issue: 27(6), P. 101119 - 101119

Published: Oct. 20, 2023

Language: Английский

Citations

3