AP-1 and SP1 trans-activate the expression of hepatic CYP1A1 and CYP2A6 in the bioactivation of AFB1 in chicken

Science China Life Sciences, Journal Year: 2024, Volume and Issue: 67(7), P. 1468 - 1478

Published: April 18, 2024

Language: Английский

---

Neurotoxic mechanisms of mycotoxins: Focus on aflatoxin B1 and T-2 toxin

Environmental Pollution, Journal Year: 2024, Volume and Issue: 356, P. 124359 - 124359

Published: June 12, 2024

Language: Английский

---

Nutrigenomics of Natural Antioxidants in Broilers

Antioxidants, Journal Year: 2024, Volume and Issue: 13(3), P. 270 - 270

Published: Feb. 22, 2024

The broiler industry supplies high-quality animal protein to the world. ban of antibiotics as growth promoters has opened way for plenty phytochemicals and antioxidants be explored. This study summarizes use natural in a diet through which deal with stressors, well their effects on expression various genes. transcriptional factors genes involved regulation redox homeostasis are described emphasis is placed nuclear factor erythroid 2-related 2 kappa B. Sources such fruits, vegetables, spices, mushrooms, algae contain numerous antioxidant compounds. activity these compounds also been confirmed at genome level. focuses oxidative stress-related genes, that regulate inflammatory response, apoptosis, response heat stress, lipid metabolism, intestinal barrier status. presented include, but not limited to, following: rutin, lycopene, magnolol, genistein, hesperidin, naringin, quercetin, curcumin, bisdemethoxycurcumin, resveratrol, astaxanthin, squalene, pterostilbene, protocatechuic acid, taraxasterol, myricetin, proanthocyanidins. Several studies have revealed dose-dependent action. Future should focus role phytogenic antibiotic alternatives relation gut microbiota eubiosis.

Language: Английский

---

Quercetin attenuates lipopolysaccharide-induced hepatic inflammation by modulating autophagy and necroptosis

Poultry Science, Journal Year: 2024, Volume and Issue: 103(6), P. 103719 - 103719

Published: April 2, 2024

Lipopolysaccharide (LPS) from Gram-negative bacteria initially induces liver inflammation with pro-inflammatory cytokines expressions. However, the underlying hepatoprotective mechanism of quercetin on LPS-induced hepatic remains unclear. Specific pathogen-free chicken embryos (n = 120) were allocated control vehicle, PBS or without ethanol LPS (125 ng/egg) treatment (10, 20, 40 nmol/egg, respectively), groups nmol/egg). Fifteen-day-old embryonated eggs inoculated abovementioned solutions via allantoic cavity. At embryonic day 19, livers collected for histopathological examination, RNA extraction, real-time polymerase chain reaction, and immunohistochemistry investigation. We found that presented inflammatory response (heterophils infiltration) after induction. The mRNA expressions inflammation-related factors (TLR4, TNFα, IL-1β, IL-10, IL-6, MYD88, NF-κB1, p38, MMP3) upregulated induction when compared group, while could downregulate these as group. Quercetin significantly decreased immunopositivity to TLR4 MMP3 in group autophagy-related genes (ATG5, ATG7, Beclin-1, LC3A, LC3B) necroptosis-related (Fas, Bcl-2, Drp1, RIPK1) LC3 group; meanwhile, protein LC3-Ⅰ, LC3-Ⅱ, rate LC3-Ⅱ/LC3-Ⅰ. In conclusions, can alleviate induced by through modulating autophagy necroptosis.

Language: Английский

---

Salvia miltiorrhiza polysaccharide mitigates AFB1-induced liver injury in rabbits

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 276, P. 116344 - 116344

Published: April 17, 2024

Aflatoxin B1 (AFB1) is one of the common dietary contaminants worldwide, which can harm liver humans and animals. Salvia miltiorrhiza polysaccharide (SMP) a natural plant-derived with numerous pharmacological activities, including hepatoprotective properties. The purpose this study to explore intervention effect SMP on AFB1-induced injury its underlying mechanisms in rabbits. rabbits were administered AFB1 (25 μg/kg/feed) or treatment (300, 600, 900 mg/kg/feed) for 42 days. results showed that effectively alleviated negative impact rabbits' productivity by increasing average daily weight gain (ADG) feed conversion rate (FCR). reduced aspartate aminotransferase (AST), alanine (ALT) alkaline phosphatase (ALP) levels serum, ameliorating hepatic pathological changes. Additionally, enhanced superoxide dismutase (SOD), catalase (CAT) glutathione (GSH) activity, inhibited reactive oxygen species (ROS), malondialdehyde (MDA), 4-Hydroxynonenal (4-HNE), interleukin-1β (IL-1β), interleukin-6 (IL-6) tumor necrosis factor-α (TNF-α) expression, thus mitigating oxidative stress inflammatory responses. Moreover, upregulated expression nuclear factor E2 related 2 (Nrf2), heme oxygenase 1 (HO-1), NADPH quinone oxidoreductase (NQO1) B-cell lymphoma (Bcl2) while downregulating kelch like ECH associated protein (Keap1), cytochrome c (cyt.c), caspase9, caspase3, Bcl-2-associated X (Bax) thereby inhibiting hepatocyte apoptosis. Consequently, our findings conclude mitigate damage activating Nrf2/HO-1 pathway mitochondria-dependent apoptotic

Language: Английский

---

Detoxification of Aflatoxin B₁ by Phytochemicals in Agriculture and Food Science

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(26), P. 14481 - 14497

Published: June 19, 2024

Aflatoxin B

Language: Английский

---

Microalgae: A promising strategy for aflatoxin control in poultry feeds

Toxicon, Journal Year: 2024, Volume and Issue: 244, P. 107770 - 107770

Published: May 18, 2024

Language: Английский

---

Efficacy of advanced chelate technology-based 7-mineral supplementation in mitigating aflatoxin B1-induced impairments in broiler chicken performance and intestinal health

Microbial Pathogenesis, Journal Year: 2025, Volume and Issue: 200, P. 107350 - 107350

Published: Jan. 31, 2025

Language: Английский

---

Innovative Mycotoxin Detoxifying Agents Decrease the Absorption Rate of Aflatoxin B1 and Counteract the Oxidative Stress in Broiler Chickens Exposed to Low Dietary Levels of the Mycotoxin

Toxins, Journal Year: 2025, Volume and Issue: 17(2), P. 82 - 82

Published: Feb. 10, 2025

Aflatoxin B1 (AFB1) can impair the growth of chickens and reduce quality eggs meat, resulting in significant economic losses. The inclusion mycotoxin detoxifying agents (MyDA) with binding properties diet is an efficient tool to their absorption rate gastrointestinal tract. Our aim was investigate ability two innovative MyDA (SeOX, a feed additive featuring tri-octahedral smectite mixed lignocellulose, CHS, di-octahedral functionalized organic non-toxic modifier) both reducing bio-accessibility mitigating adverse effects AFB1 broilers exposed for 10 days concentrations approaching European Union maximum limits (0.02 mg/kg). amount excreta birds, collected over four consecutive (starting on day 7), significantly lower (p < 0.001) group alone compared groups treated either SeOX or CHS. calculated decreased by nearly 30% MyDA. This positive effect reflected reduction oxidative stress (measured as serum antioxidant capacity hepatic lipid peroxidation) induced AFB1. Although enzyme activities glutathione levels were unaffected any treatment, upregulation CYP2A6 downregulation Nrf2; latter reverted each Overall, these results demonstrate that selected are effective limiting rate, thereby even reverting broilers.

Language: Английский

---

The effects of formic acid or herbal mixture on growth performance, carcass quality, blood chemistry, and gut microbial load in broiler chickens

Poultry Science, Journal Year: 2025, Volume and Issue: unknown, P. 105085 - 105085

Published: March 1, 2025

The purpose of this research was to assess the effects formic acid (FORM) and an herbal mixture (HM) as antibiotic alternatives in broiler meals on growth efficiency, carcass criteria, blood parameters, intestinal bacterial populations. A total 360 one-day-old Ross 308 chicks were assigned six trial treatments using a totally randomized method. Each group consisted 6 replicates, with 10 unsexed per replicate. groups arranged follows: NC (negative control, basal diet); PC (positive diet + 0.5 g Polymyxin E antibiotic/kg Form2, Form4, HM3, HM6 (basal supplemented 2 or 4 ml acid, 3 mixture/kg diet, respectively). findings showed no substantial variations "body weight (BW) body gain (BWG)" among relative groups. HM g/kg exhibited higher "feed intake (FI) improved feed conversion ratio (FCR)" other treatments. Carcass characteristics not substantially impacted by supplementation, except for spleen weight, which highest group. Significant changes parameters observed, notable ALT AST activity "urea, creatinine, protein, globulin, albumin" levels supplementation also increased antioxidant (GPx, GST, GSH) compared while reducing MDA Additionally, significantly reduced harmful populations cecal samples. Conversely, Lactobacilli counts greater than those groups, although significant variances Clostridium observed. In conclusion, supplementing mixtures positively influences status, microbiota.

Language: Английский

---