Medical Research Archives,
Journal Year:
2023,
Volume and Issue:
11(12)
Published: Jan. 1, 2023
Background:
This
perspective
concerning
hepatoxicity
of
per-
and
polyfluoroalkyl
substances
(PFAS)
aims
to
provide
a
current
understanding
the
damage
reasonable
clinician
responses
needs
concerned
patients
affected
communities.
Methods:
Search
strategy
included
PFAS
following:
human
liver
toxicity/disease;
relevant
biomarkers
including
transaminases,
lipids,
uric
acid;
predictive
equations
(for
disease),
imaging
modalities,
histologic
findings.
Experimental
data
outcomes
disrupted
hepatic
metabolic
pathways
was
also
reviewed.
Recommended
clinical
approaches
communities
sought
in
both
National
Library
Medicine
organizational
websites.
Results:
Several
reliably
cause
adverse
changes
biomarkers,
with
strong
consistency
between
experimental
data.
Adverse
population
include
cholesterol
LDL
cholesterol,
acid.
biomarker
triad
suggests
that
mechanisms
are
or
resemble
associated
steatotic
disease,
which
is
found
across
species
following
exposure.
Human
studies
sparse
mostly
support
inference
toxicant
resembles
pathway
can
lead
from
steatosis
more
serious
stages
disease
due
metabolism
fatty
acids.
Advice
clinicians
reviewed
various
agencies
nonprofits
organizations
committee
US
Academies
Sciences,
Engineering,
Medicine,
nonprofit/university
collaboration
REACH.
Discussion:
Converging
lines
evidence
indict
as
(and
trans-species)
hepatotoxins
continuum
nature
injury.
Increases
abnormal
transaminases
sparser
biopsy
findings
clinically
important
contributing
public
health
problem.
It
still
challenging
decide
many
definitively
is/are
most
Many
use
remain
virtually
unstudied,
research
emergency.
Simple
concerns
heavily
contaminated
communities,
within
capabilities
offices,
Chemical Research in Toxicology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 11, 2025
Polyfluoroalkyl
substances
(PFAS)
are
widely
used
industrial
compounds
that
have
been
identified
as
contaminants
in
almost
every
component
of
the
global
ecosystem,
and
human
studies,
higher
levels
PFAS
correlated
with
increased
incidence
multiple
diseases.
Based
on
results
laboratory
animal
we
hypothesize
orphan
nuclear
receptor
4A1
(NR4A1)
may
be
a
critical
target
for
some
such
legacy
linear
polyfluorooctanesulfonate
(PFOS)
other
sulfonates.
We
show
PFOS
related
bound
ligand
binding
domain
(LBD)
NR4A1
induced
growth
several
cancer
cell
lines
enhanced
tumor
an
athymic
nude
mouse
model.
Using
NR4A1-responsive
rhabdomyosarcoma
Rh30
cells
model,
NR4A1-dependent
proliferation
migration
invasion.
Moreover,
cells,
also
induces
NR4A1-regulated
genes
including
PAX3-FOXO1
oncogene
downstream
gene
products,
chromatin
immunoprecipitation
assay,
does
not
decrease
to
promoter.
These
demonstrate
is
enhances
tumorigenesis
through
activation
this
receptor.
Life,
Journal Year:
2025,
Volume and Issue:
15(4), P. 573 - 573
Published: April 1, 2025
Per-
and
polyfluoroalkyl
substances
(PFASs)
are
among
the
persistent
organic
pollutants
characterized
by
their
persistence
in
environment,
high
mobility,
adverse
impact
not
only
on
ecosystem
but
also
human
health.
The
biggest
challenges
biomonitoring
low
concentrations
of
PFASs
biological
matrices
presence
matrix
interferents
samples.
combination
liquid
chromatography
with
tandem
mass
spectrometry
(LC-MS/MS)
solid-phase
extraction
(SPE)
as
a
sample
preparation
technique
appears
to
be
most
suitable
solution
for
achieving
desired
selectivity
sensitivity
PFAS
determination.
aim
this
review
is
describe
possible
sources
PFASs,
various
matrices,
analytical
methods
determining
different
using
pretreatment
techniques
complex
samples,
well
health
risks
associated
exposure.
studied
include
PFOA
PFOS,
which
frequently
detected
such
plasma,
serum,
breast
milk.
average
range
from
1.0
2.6
ng.mL−1
1.9
2.4
0.4
3.1
For
were
2.0–4.0
ng.mL−1,
3.7–4.6
3.6–4.8
milk,
respectively.
significant
effects
exposure
long-chain
(such
PFOS)
lipid
disorders,
hypertension,
diabetes
mellitus,
thyroid
infertility,
cancer,
obesity,
autism,
neurodevelopmental
issues,
cardiovascular
diseases,
kidney
liver
disorders.
It
utmost
importance
monitor
exposure,
predict
toxicity,
develop
effective
strategies
mitigate
potential
Ecotoxicology and Environmental Safety,
Journal Year:
2024,
Volume and Issue:
277, P. 116368 - 116368
Published: April 25, 2024
Perfluorooctane
sulfonate
(PFOS)
is
a
persistent
chemical
that
has
long
been
threat
to
human
health.
However,
the
molecular
effects
of
PFOS
on
various
organs
are
not
well
studied.
In
this
study,
male
Sprague–Dawley
rats
were
treated
with
doses
through
gavage
for
21
days.
Subsequently,
liver,
lung,
heart,
kidney,
pancreas,
testis,
and
serum
harvested
lipid
analysis.
We
applied
focusing
lipidomic
analytical
strategy
identify
key
responses
phosphorylcholine-containing
lipids,
including
phosphatidylcholines
sphingomyelins.
Partial
least
squares
discriminant
analysis
revealed
most
influenced
by
exposure
testis.
Changes
in
profiles
indicated
after
exposure,
levels
diacyl-phosphatidylcholines
22:6-containing
testis
decreased,
whereas
level
20:3-containing
increased.
Furthermore,
polyunsaturated
fatty
acids-containing
plasmenylcholines
decreased.
sphingomyelin
organ-dependent
responses.
Decreased
sphingomyelins
nonmonotonic
dose
irregular
observed.
These
may
be
associated
alterations
pertaining
phosphatidylcholine
synthesis,
acid
metabolism,
membrane
properties,
oxidative
stress
Lipid
liver
could
have
contributed
observed
increase
body
weight
ratios.
The
findings
suggest
potential
toxicity
possible
mechanisms
multiple
organs.
