The potential roles of HIF-1α in epithelial-mesenchymal transition and ferroptosis in tumor cells

Cellular Signalling, Journal Year: 2024, Volume and Issue: 122, P. 111345 - 111345

Published: Aug. 10, 2024

In tumors, the rapid proliferation of cells and imperfect blood supply system lead to hypoxia, which can regulate adaptation tumor hypoxic environment through hypoxia-inducible factor-1α (HIF-1α) promote development in multiple ways. Recent studies have found that epithelial-mesenchymal transition (EMT) ferroptosis play important roles progression cells. The activation HIF-1α is considered a key factor inducing EMT When activated, it EMT-related genes, causing gradually lose their epithelial characteristics acquire more invasive mesenchymal traits. occurrence allows better adapt changes surrounding tissue, enhancing migratory capabilities, thus promoting progression. At same time, also plays crucial regulatory role environment, may affect processes such as iron metabolism oxidative stress responses, This article briefly reviews dual cells, helping gain deeper understanding pathways providing new perspective for pathogenesis tumors. regulation become an strategy future therapy.

Language: Английский

---

Astaxanthin Alleviates Oxidative Stress in Mouse Preantral Follicles and Enhances Follicular Development Through the AMPK Signaling Pathway

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2241 - 2241

Published: March 2, 2025

This study investigates the effects of astaxanthin on oxidative stress, mitochondrial function, and follicular development in mouse preantral follicles, with a focus involvement adenosine monophosphate-activated protein kinase (AMPK) signaling pathway. Astaxanthin (2.5 nM) significantly enhanced both antrum formation (from 85.96% control group to 94.38% group) maturation rates 79.15% 85.12%) oocytes (p < 0.05). From day 4 vitro culture, notably increased area follicle attachment 0.06 µm2 0.32 µm2) secretion estradiol 32.10 ng/L 49.73 ng/L) Additionally, it decreased malondialdehyde content 80.54 μM 62.65 μM) within follicles while increasing mRNA expression levels glutathione superoxide dismutase 1 also reduced reactive oxygen species Notably, p-AMPK PGC-1α, which are key proteins for AMPK pathway; NRF1 TFAM, crucial biogenesis; NRF2 HO-1, protect against stress; CO1, CO2, CO3, ATP6, ATP8, TOM20, essential electron transport chain activity ATP synthesis; PINK1, Parkin, LC3-II, involved mitophagy; Bcl-2, inhibits cell apoptosis; StAR P450scc, promote estrogen synthesis Furthermore, improved membrane potential cleaved caspase 3, Bax, P53, promotes apoptosis However, these changes induced by were completely reversed inhibitors, indicating Conclusively, enhances alleviates stress function during may be mediated

Language: Английский

---

Effects of tefluthrin exposure on early life stages in zebrafish: Insights into cardiac and skeletal development, oxidative stress and apoptosis

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 292, P. 117931 - 117931

Published: Feb. 19, 2025

Language: Английский

---

Lycopene Regulates Nrf2 to Ameliorate Sulfamethoxazole -Induced Renal Injury and Apoptosis via Inhibiting Oxidative Stress and Endoplasmic Reticulum Stress

Aquatic Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 107348 - 107348

Published: March 1, 2025

Language: Английский

---

Astaxanthin alleviates fipronil-induced neuronal damages in male rats through modulating oxidative stress, apoptosis, and inflammatory markers

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 24, 2025

Language: Английский

---

Recent advances in potential therapeutic targets of ferroptosis‑associated pathways for the treatment of stroke (Review)

Molecular Medicine Reports, Journal Year: 2024, Volume and Issue: 30(1)

Published: May 22, 2024

Stroke is a severe neurological disease that associated with high rates of morbidity and mortality, the underlying pathological processes are complex. Ferroptosis fulfills significant role in progression treatment stroke. It well established ferroptosis type programmed cell death distinct from other forms or types death. The process involves multiple signaling pathways regulatory mechanisms interact inherent to stroke development. Inducers inhibitors have been shown exert onset this process. Furthermore, it has interfering affects occurrence stroke, indicating targeting may offer promising therapeutic approach for treating patients Hence, present review aimed summarize latest progress made terms using interventions as targets cases provides an overview relevant molecular investigated recent years, highlighting roles inducers Additionally, intervention potential various Traditional Chinese Medicine also summarized. In conclusion, comprehensive afforded by ferroptosis‑associated offering new insights into how be exploited

Language: Английский

---

Physiological and transcriptomic changes of zebrafish (Danio rerio) in response to Isopropylate Triphenyl Phosphate (IPPP) exposure

Environmental Toxicology and Pharmacology, Journal Year: 2024, Volume and Issue: 110, P. 104528 - 104528

Published: Aug. 8, 2024

Language: Английский

---

Environmentally Relevant Concentrations of Triphenyl Phosphate (TPhP) Impact Development in Zebrafish

Toxics, Journal Year: 2024, Volume and Issue: 12(5), P. 368 - 368

Published: May 16, 2024

A common flame-retardant and plasticizer, triphenyl phosphate (TPhP) is an aryl ester found in many aquatic environments at nM concentrations. Yet, most studies interrogating its toxicity have used µM In this study, we the model organism zebrafish (

Language: Английский

---

Integrative analysis of transcriptomics and metabolomics reveals the protective effect and mechanism of salidroside on testicular ischemia-reperfusion injury

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: May 16, 2024

Testicular torsion is a critical urologic condition for which testicular detorsion surgery considered irreplaceable as well the golden method of reversal. However, surgical treatment equivalent to blood reperfusion process, and no specific drugs are available treat injuries. Salidroside (SAL) one main effective substances in rhodiola, has been shown have antioxidant antiapoptosis activities. This study was designed determine whether SAL exerted protective effect on ischemia-reperfusion (I/R) injury. In this study, I/R injury model testes reoxygenation (OGD/R) were used verification, administered at doses 100 mg/kg 0.05 mmol/L, respectively. After experiments, tissue TM4 Sertoli cells collected histopathologic biochemical analyses. The results revealed that improves structure regulates oxidation–antioxidation system. To further understand molecular mechanisms treating injuries, transcriptomics metabonomics analyses integrated. show Nfr2/HO-1/GPX4/ferroptosis signaling pathway enriched significantly, indicating it may be regulatory Thereafter, transfection with Nrf2 plasmid–liposome reverse verify anti-testicular treatment. Thus, suggested can protect against injuries by regulating Nfr2/HO-1/GPX4 inhibit ferroptosis potential drug

Language: Английский

---

Visual toxicity in zebrafish larvae following exposure to 2,2′,4,4′-tetrabromodiphenyl ether (BDE-47), triphenyl phosphate (TPhP), and isopropyl phenyl diphenyl phosphate (IPPP)

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 950, P. 175131 - 175131

Published: Aug. 9, 2024

Language: Английский

---