Exploring the association between exposure to pesticides, polycyclic aromatic hydrocarbons, and phthalates and metabolic syndrome in National Health and Nutrition Examination Survey in the USA, 2007–2012: utilizing a multi-step statistical strategy

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 14, 2025

Pesticides, polycyclic aromatic hydrocarbons (PAHs), and phthalates are recognized as potential contributors to metabolic disorders. Nevertheless, the combined effect of simultaneous exposure these chemicals on syndrome (MetS) remains elusive. To explore impacts pesticides, PAHs identify critical MetS. Based National Health Nutrition Examination Survey (NHANES) database from 2007—2012, our study included 4030 non-pregnant individuals aged 20 years or older. We used weighted linear regression model, variable selection models (including LASSO BMA models), well a mixture model (WQS model) investigate correlation between Additionally, stratified analyses were performed based gender age. The generalized revealed positive 2-hydroxyphenanthrene (2-PHEN) with MetS (OR: 1.37, 95% CI: 1.19–1.59, P < 0.001). Both identified 2-PHEN significant chemical positively associated WQS showed association overall three categories MetS, highest being 2-PHEN. Stratified demonstrated different subgroups. Notably, in subgroup female (OR = 1.40, 1.08–1.83, 0.05), 2-PHEN, 2,5-dichlorophenol (2,5-DCP), 2-hydroxynaphthalene (2-NAP), mono-ethyl phthalate (MEP) primary contributions Combined groups was an increased risk group exhibiting most pronounced emerging key chemical, underscoring public health concerns regarding risks endocrine-disrupting (EDCs) diseases.

Language: Английский

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Association between phthalate exposure and metabolic dysfunction-associated steatotic liver disease (MASLD) – systematic literature review

Environmental Research, Journal Year: 2025, Volume and Issue: unknown, P. 121186 - 121186

Published: Feb. 1, 2025

Language: Английский

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Association of Personal Care and Consumer Product Chemicals with Long-Term Amenorrhea: Insights into Serum Globulin and STAT3

Toxics, Journal Year: 2025, Volume and Issue: 13(3), P. 187 - 187

Published: March 5, 2025

Chemicals in personal care and consumer products are suspected to disrupt endocrine function affect reproductive health. However, the link between mixed exposure long-term amenorrhea is not well understood. This study analyzed data from 684 women (2013–2018 National Health Nutrition Examination Survey) assess eight polyfluorinated alkyl substances (PFASs), 15 phthalates (PAEs), six phenols, four parabens. Various statistical models for robustness tests mediation analysis were used explore associations with role of serum globulin. Biological mechanisms identified through an integrated strategy involving target key chemicals intersections, pathway analysis, validation. Results showed that had higher levels Perfluorodecanoic acid, Perfluorohexane sulfonic acid (PFHxS), Perfluorononanoic n-perfluorooctanoic (n_PFOA), n-perfluorooctane Perfluoromethylheptane isomers. Logistic regression different adjustments consistently found significant elevated PFAS concentrations increased risk, confirmed by Partial Least Squares Discriminant Analysis. Mediation revealed globulin partially mediated relationship amenorrhea. Network suggested PFHxS n_PFOA may interact Signal Transducer Activator Transcription 3 (STAT3). highlights exposure, particularly n_PFOA, amenorrhea, STAT3 serving as mediators underlying mechanisms.

Language: Английский

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First Evidence in the Association of Phenolic Endocrine-Disrupting Chemicals with Secondary Non-Alcoholic Fatty Liver Disease: A Case-Control Study in South China

Environmental Pollution, Journal Year: 2025, Volume and Issue: unknown, P. 126086 - 126086

Published: March 1, 2025

Language: Английский

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Quality assurance and quality control for human biomonitoring data—focus on matrix reference materials

Analytical and Bioanalytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

Language: Английский

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Metabolism-Disrupting Chemical Mixtures during Pregnancy, Folic Acid Supplementation, and Liver Injury in Mother-Child Pairs

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 14, 2024

Scarce knowledge about the impact of metabolism-disrupting chemicals (MDCs) on liver injury limits opportunities for intervention. We evaluated pregnancy MDC-mixture associations with and effect modification by folic acid (FA) supplementation in mother-child pairs. studied ∼200 pairs from Mexican PROGRESS cohort, measured 43 MDCs during (estimated air pollutants, blood/urine metals or metalloids, urine high- low-molecular-weight phthalate [HMWPs, LMWPs] organophosphate-pesticide [OP] metabolites), serum enzymes (ALT, AST) at ∼9 years post-parturition. defined as elevated children, using established clinical scores steatosis fibrosis mothers (i.e., AST:ALT, FLI, HSI, FIB-4). Bayesian Weighted Quantile Sum regression assessed outcomes. further examined chemical-chemical interactions self-reported FA supplementation. In many MDC-mixtures were associated Per quartile HMWP-mixture increase, ALT increased 10.1% (95%CI: 1.67%, 19.4%) AST 5.27% (95% CI: 0.80%, 10.1%). LMWP-mixtures pollutant-mixtures higher ALT, respectively. Air pollutant non-essential metal/element attenuated maternal cobalt blood concentrations ( p -interactions<0.05). mothers, only LMWP-mixture was [OR=1.53 1.01, 2.28) HSI>36, OR=1.62 1.05, 2.49) AST:ALT<1]. most (null) supplementation≥600mcg/day Pregnancy MDC exposures may increase risk, particularly children. These be levels.

Language: Английский

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Cumulative exposure to AHA Life's Essential 8 is associated with nonalcoholic fatty liver disease: a large cohort study

Nutrition & Metabolism, Journal Year: 2024, Volume and Issue: 21(1)

Published: June 27, 2024

We aimed to explore the associations of baseline and cumulative cardiovascular health with nonalcoholic fatty liver disease (NAFLD) development regression using new Life's Essential 8 score.

Language: Английский

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Impact of metabolism-disrupting chemicals and folic acid supplementation on liver injury and steatosis in mother-child pairs

Journal of Hepatology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

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Toxic Beauty: Parabens and Benzophenone-type UV Filters Linked to Increased Non-Alcoholic Fatty Liver Disease Risk

Chemosphere, Journal Year: 2024, Volume and Issue: unknown, P. 143555 - 143555

Published: Oct. 1, 2024

Language: Английский

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