Windows of Susceptibility to Air Pollution During and Surrounding Pregnancy in Relation to Longitudinal Maternal Measures of Adiposity and Lipid Profiles DOI
Sandra India Aldana, Danielle Demateis, Damaskini Valvi

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 26, 2024

Abstract Pregnancy is a critical window for long-term metabolic programming of fetal effects stemming from airborne particulate matter ≤2.5μm (PM 2.5 ) exposure. Yet, little known about PM exposure during and surrounding pregnancy in mothers. We assessed potential windows with maternal adiposity lipid measures later life. included 517 pregnant women the PROGRESS cohort [body mass index (BMI), waist circumference (WC), % body fat] lipids [total cholesterol, high-density-lipoprotein (HDL), low-density-lipoprotein (LDL)] measured repeatedly at 4, 6 8 years post-delivery. Monthly average was estimated each participant’s address using validated spatiotemporal model. employed distributed lag interaction models (DLIMs) adjusting socio-demographics clinical covariates. found that 1 μg/m 3 increase throughout mid-/late-pregnancy associated higher WC 6-years post-delivery, peaking months gestation: 0.04 cm (95%CI: 0.01, 0.06). also identified LDL lower HDL both 4 post-delivery peaks pre-conception [0.17 mg/dL 0.00, 0.34)] 11 th month after conception [-0.07 -0.11, -0.02)]. Stratified analyses by sex indicated stronger associations mothers carrying male, whereas were observed female fetus. deleterious lagged folic acid intake than 600mcg/day pregnancy.

Language: Английский

Windows of Susceptibility to Air Pollution During and Surrounding Pregnancy in Relation to Longitudinal Maternal Measures of Adiposity and Lipid Profiles DOI
Sandra India Aldana, Danielle Demateis, Damaskini Valvi

et al.

Environmental Research, Journal Year: 2025, Volume and Issue: unknown, P. 121198 - 121198

Published: Feb. 1, 2025

Language: Английский

Citations

1
Windows of Susceptibility to Air Pollution During and Surrounding Pregnancy in Relation to Longitudinal Maternal Measures of Adiposity and Lipid Profiles DOI
Sandra India Aldana, Danielle Demateis, Damaskini Valvi

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 26, 2024

Abstract Pregnancy is a critical window for long-term metabolic programming of fetal effects stemming from airborne particulate matter ≤2.5μm (PM 2.5 ) exposure. Yet, little known about PM exposure during and surrounding pregnancy in mothers. We assessed potential windows with maternal adiposity lipid measures later life. included 517 pregnant women the PROGRESS cohort [body mass index (BMI), waist circumference (WC), % body fat] lipids [total cholesterol, high-density-lipoprotein (HDL), low-density-lipoprotein (LDL)] measured repeatedly at 4, 6 8 years post-delivery. Monthly average was estimated each participant’s address using validated spatiotemporal model. employed distributed lag interaction models (DLIMs) adjusting socio-demographics clinical covariates. found that 1 μg/m 3 increase throughout mid-/late-pregnancy associated higher WC 6-years post-delivery, peaking months gestation: 0.04 cm (95%CI: 0.01, 0.06). also identified LDL lower HDL both 4 post-delivery peaks pre-conception [0.17 mg/dL 0.00, 0.34)] 11 th month after conception [-0.07 -0.11, -0.02)]. Stratified analyses by sex indicated stronger associations mothers carrying male, whereas were observed female fetus. deleterious lagged folic acid intake than 600mcg/day pregnancy.

Language: Английский

Citations

0