Mitochondrial DNA leakage: underlying mechanisms and therapeutic implications in neurological disorders
Guangming Zhang,
No information about this author
Huayuan Wei,
No information about this author
Anliu Zhao
No information about this author
et al.
Journal of Neuroinflammation,
Journal Year:
2025,
Volume and Issue:
22(1)
Published: Feb. 7, 2025
Mitochondrial
dysfunction
is
a
pivotal
instigator
of
neuroinflammation,
with
mitochondrial
DNA
(mtDNA)
leakage
as
critical
intermediary.
This
review
delineates
the
intricate
pathways
leading
to
mtDNA
release,
which
include
membrane
permeabilization,
vesicular
trafficking,
disruption
homeostatic
regulation,
and
abnormalities
in
dynamics.
The
escaped
activates
cytosolic
sensors,
especially
cyclic
gmp-amp
synthase
(cGAS)
signalling
inflammasome,
initiating
neuroinflammatory
cascades
via
pathways,
exacerbating
spectrum
neurological
pathologies.
therapeutic
promise
targeting
discussed
detail,
underscoring
necessity
for
multifaceted
strategy
that
encompasses
preservation
homeostasis,
prevention
leakage,
reestablishment
dynamics,
inhibition
activation
sensors.
Advancing
our
understanding
complex
interplay
between
neuroinflammation
imperative
developing
precision
interventions
disorders.
Language: Английский
Piezo1 deficiency alleviates acute liver failure by inhibiting CpG-ODN induced inflammatory responses
Ruxia Zhao,
No information about this author
Xiaoyu Zhang,
No information about this author
Xinyue Liu
No information about this author
et al.
International Immunopharmacology,
Journal Year:
2025,
Volume and Issue:
159, P. 114879 - 114879
Published: May 19, 2025
Language: Английский
Unveiling the role of mtDNA in Liver-Kidney Crosstalk: Insights from trichloroethylene hypersensitivity syndrome
Xulei Zuo,
No information about this author
Lei Gao,
No information about this author
Xinyu Peng
No information about this author
et al.
International Immunopharmacology,
Journal Year:
2024,
Volume and Issue:
138, P. 112513 - 112513
Published: June 24, 2024
Language: Английский
Mitochondrial dysfunction induced by trichloroethylene in Parkinson’s disease
Neda M. Ilieva,
No information about this author
Ashley Adamson,
No information about this author
Mohammed Ghalib
No information about this author
et al.
Advances in neurotoxicology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
Language: Английский
Ameliorative actions of ginseng flower alcoholic extract, on drug-induced hepatotoxicity: A focus on PI3K/AKT/mTOR signaling modulation and intestinal microbiome homeostasis
Ming Jin,
No information about this author
Yibin Xing,
No information about this author
Xin Qi
No information about this author
et al.
Journal of Functional Foods,
Journal Year:
2024,
Volume and Issue:
122, P. 106482 - 106482
Published: Oct. 19, 2024
Language: Английский