Editorial: Environmental threats to human reproduction DOI Creative Commons
Roland Eghoghosoa Akhigbe

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 2, 2024

These environmental stressors acts via multiple pathways. First, they disrupt the endocrine system by mimicking or blocking sex hormones (Akhigbe et al., 2022). They may also induce oxidative stress upregulating generation of free radicals and suppressing antioxidants (Kumar 2018;Akhigbe 2021), trigger inflammation immune response (Li 2021;Ashonibare 2024b), promote genotoxicity (Choudhuri 2021) Although SARS-CoV-2 remains quite novel, convincing evidences have been provided on its possible link with infertility Hamed, 2020;Adeyemi 2022)

Language: Английский

Ureaplasma urealyticum upregulates seminal fluid leukocytes and lowers human semen quality: a systematic review and meta-analysis DOI Creative Commons

Omotola SeunFunmi Kukoyi,

Victory Jesutoyosi Ashonibare,

Cecilia Adedeji Adegbola

et al.

Basic and Clinical Andrology, Journal Year: 2025, Volume and Issue: 35(1)

Published: April 17, 2025

Abstract Background Ureaplasma urealyticum belongs to the class Mollicutes and causes non-gonococcal urethritis, an inflammation of urethra that is linked with impaired semen quality. However, some reports are contradictory, reported effect U. on specific sperm variables not consistent. Thus, this study synthesized findings from published primary data provides a robust reliable inference impact associated mechanisms Methods A systematic search was conducted until 31st May, 2024, Cochrane, Google Scholar, Pubmed. The Population, Exposure, Comparator/Comparison, Outcomes, Study Design (PECOS) model adopted. populations were male in their reproductive ages who infected confirmed positive versus control age-matched non-infected or treated, while outcomes included conventional parameters, seminal fluid leucocyte count, interleukin-6 (IL-6) concentrations, studies either cross-sectional longitudinal. Results When compared control, quantitative analysis demonstrated significantly reduced ejaculate volume (SMD 0.33 [95% CI: 0.15, 0.52] p = 0.0004), concentration 0.47 0.31, 0.64] < 0.00001), total motility 0.73 0.43, 1.02] motile count 0.21 0.17, 0.26] normal morphology 0.88 0.42, 1.35] 0.0002), but increased leukocyte -0.82 -1.61, -0.02] 0.04). In addition, qualitative revealed urealyticum- subjects had higher levels IL-1β, IL-6, IL-8, TNF-α, peroxidase, leukocytes , neutrophils, CD4 + T cells, CD8 cells when control. Furthermore, DNA fragmentation apoptotic observed Conclusions These lowers quality via upregulation leukocytes, elastase, pro-inflammatory cytokines, fragmentation. further required elucidate underlying association between decline develop effective therapies for condition.

Language: Английский

Citations

0
Impact of arsenic on male and female reproductive function: a review of the pathophysiology and potential therapeutic strategies DOI
Adetomiwa Ezekiel Adeogun,

Olajumoke Deborah Ogunleye,

Tunmise Maryanne Akhigbe

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 17, 2024

Language: Английский

Citations

2
A systematic review and meta-analysis of the impact of triclosan exposure on human semen quality DOI Creative Commons

Cecilia Adedeji Adegbola,

Tunmise Maryanne Akhigbe, Adetomiwa Ezekiel Adeogun

et al.

Frontiers in Toxicology, Journal Year: 2024, Volume and Issue: 6

Published: Oct. 17, 2024

Introduction Triclosan is an antibacterial and antifungal compound that frequently found in personal care consumer products, its impact on male reproductive health a growing concern. Despite existing experimental studies demonstrating potential threats to fertility, reports effects human semen quality remains limited inconsistent. Therefore, this study presents systematic review meta-analysis assessing the relationship between triclosan exposure quality. Methods This was registered with PROSPERO (CRD42024524192) adhered PRISMA guidelines. Results The analyzed 562 screened studies, out of which five articles including 1,312 subjects were finally included study. eligible geographically diverse, three from China, one Belgium, Poland. More so, both case-control cross-sectional. revealed significantly reduced sperm concentration (Standard Mean Difference (SMD) −0.42 [95% CI: −0.75, −0.10], P = 0.01) total motility (SMD −1.30 −2.26, −0.34], 0.008). Mechanistic insights animal vitro showed oxidative stress may mediate adverse Discussion first comprehensive evaluation quality, highlighting impair fertility through reductions motility. However, high heterogeneity among underscores need for further high-quality research establish more definitive conclusions regarding health.

Language: Английский

Citations

1
Editorial: Environmental threats to human reproduction DOI Creative Commons
Roland Eghoghosoa Akhigbe

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 2, 2024

These environmental stressors acts via multiple pathways. First, they disrupt the endocrine system by mimicking or blocking sex hormones (Akhigbe et al., 2022). They may also induce oxidative stress upregulating generation of free radicals and suppressing antioxidants (Kumar 2018;Akhigbe 2021), trigger inflammation immune response (Li 2021;Ashonibare 2024b), promote genotoxicity (Choudhuri 2021) Although SARS-CoV-2 remains quite novel, convincing evidences have been provided on its possible link with infertility Hamed, 2020;Adeyemi 2022)

Language: Английский

Citations

0