Rising Concern About the Carcinogenetic Role of Micro-Nanoplastics DOI Open Access
Lorenzo Ruggieri, Ottavia Amato, Cristina Marrazzo

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 26(1), P. 215 - 215

Published: Dec. 30, 2024

In recent years, awareness regarding micro-nanoplastics’ (MNPs) potential effects on human health has progressively increased. Despite a large body of evidence the origin and distribution MNPs in environment, their impact remains to be determined. this context, there is major need address carcinogenic risks, since could hypothetically mediate direct indirect effects, latter mediated by particle-linked chemical carcinogens. Currently, field scarce heterogeneous, but reported increased incidence malignant tumors among younger populations, together with ubiquitous environmental abundance MNPs, are rising global concern possible role development progression cancer. review, we provide an overview currently available eco-toxicology, as well methods for identification characterization MNP particulates health-associated focus addition, suggest routes future research order unravel carcinogenetic exposure understand prognostic preventive implications intratumoral MNPs.

Language: Английский

Oral exposure to nanoplastics altered lipid profiles in mouse intestine DOI

Sihuan Luo,

Xiaomei Zhao,

Yijin Wang

et al.

Food and Chemical Toxicology, Journal Year: 2025, Volume and Issue: 197, P. 115304 - 115304

Published: Feb. 2, 2025

Language: Английский

Citations

1
Exploring Toxicological Pathways of Microplastics and Nanoplastics: Insights from Animal and Cellular Models DOI Creative Commons

Luna Bridgeman,

Alessandra Cimbalo,

David López-Rodríguez

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 137795 - 137795

Published: March 1, 2025

Microplastics (MPs) and nanoplastics (NPs) represent an emerging issue for human animal health. This review critically examines in vitro vivo studies to elucidate their mechanisms of action toxicological effects. Key objectives included: providing a comprehensive overview MP-NPs literature, assessing experimental conditions relative real environmental scenarios, identifying pathways at the molecular level. The findings revealed significant progress understanding impacts. In particular, it has been observed promotion inflammation, oxidative stress, apoptosis, autophagy, endoplasmic reticulum (ER) stress via specific signaling axes. Reproductive toxicity emerged as primary research focus, particularly male models, whereas effects on gastrointestinal, neurological, cardiovascular systems were insufficiently studied, especially affected. Most disproportionately focused polystyrene particles, neglecting other prevalent polymers such polyethylene polypropylene. Furthermore, reliance synthetic microspheres non-realistic concentrations limits relevance real-world conditions. Limited long-term exposure further constrain persistence risks. view this, future should integrate environmentally relevant particles doses, size composition, assessments, advanced methodologies omics computational modeling. addition, therapeutic interventions targeting ER inflammation apoptosis may be excellent solution mitigate toxicity. At same time, standardized global approach is needed fully understand risks posed by MP-NPs, attempting safeguard public

Language: Английский

Citations

1
Short-term oral exposure to nanoplastics does not significantly impact the antiviral immune response of the mouse DOI

G. Lopez,

Yasmine Adda-Bouchard,

Xavier Laulhé

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 488, P. 137316 - 137316

Published: Jan. 21, 2025

Language: Английский

Citations

0
Understanding the Mechanism of Cardiotoxicity Induced by Nanomaterials: A Comprehensive Review DOI Creative Commons
Zaiyong Zheng, Shuang Zhu, Xiaobo Wang

et al.

Small Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 20, 2025

Nanomaterials have been vastly used in daily life. However, owing to their unique properties, nanomaterials also show potential side effects. Among the various organs affected by nanomaterials, circulatory system stands out as particularly vulnerable, drawing additional attention its cardiac toxicity. To address cardiovascular nanotoxicity and further promote safe use of nanotechnology, a comprehensive review cardiotoxicity induced is provided. The begins identifying current research trends hotspots this field via bibliometric analysis. Subsequently, based on objectively obtained hotspots, mechanism nanotoxicity, including exposure route, membrane injury, ion disturbance, oxidative stress, inflammation, cell death, reviewed discussed. Finally, strategies for mitigation are proposed. objective assist readers understanding facilitate application human health.

Language: Английский

Citations

0
Artificial plasticenta: how polystyrene nanoplastics affect in-vitro cultured human trophoblast cells DOI Creative Commons
Antonio Ragusa, Loredana Cristiano, Pierluigi Di Vinci

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 24, 2025

In the human placenta, we have detected MPs by Raman microspectroscopy analysis and, for first time, with transmission electron microscopy. fragments been localized in different compartments of placental tissue, free cytoplasm and within organelles like lysosomes. Moreover, their presence has correlated ultrastructural alterations some cell organelles, typical metabolic stress, mainly dilated rough endoplasmic reticulum numerous swollen electrodense mitochondria, as well signs derived from involuting organelles. As a result, speculated that microplastics placenta could be responsible pathological traits activation such oxidative apoptosis, inflammation causing long-term effects on health mother child. To demonstrate cytotoxicity PS-NPs confirm vivo results, performed vitro experiments trophoblast line, HTR8/SVneo cells. cells were treated, 24 h 48h, increasing concentrations (10, 25, 50, 75, 100 μg/mL) 0.05 µm polystyrene (PS) cellular viability was evaluated Counting Kit-8. Fluorescent examined under fluorescence/confocal microscopy used to investigate internalization plastics Transmission evaluate possible PS-NPs-dependent Our study shows starting exposure, treatment, at 50 μg/mL dose, cytotoxic effect cells, death 40% affecting morphology surviving addition, alter ultrastructure those already described vivo. We found NPs enter mitochondria morphology, accumulating aggregates lysosome-like Interestingly these become larger concentration increases. accumulation inside result prolonged impossible attempt remove destroy PS. This would lead ER mitochondrial impairing mitochondria/ER functions thus activating apoptotic pathway suggesting act stressor, leading support our hypothesis, also associated morphological regression degeneration, highly vacuolized cytoplasm, dilatation, vesiculation ER, uncoupling/loss cytoplasmic fragments, deriving lysis. Based immunofluorescence study, together degeneration stress. An abnormal amount might determine persistent alarm CDR (cell danger response), evolutionarily conserved response protects hosts harm triggered chemical (as case NPs/MPs), physical, or biological agents exceed capacity homeostasis. further help inevitable exposure MPs/NPs environment, which characterizes modern world, partially epidemic non-transmissible disease.

Language: Английский

Citations

0
Unraveling the Impact of Micro- and Nano-sized Polymethyl methacrylate on Gut Microbiota and Liver Lipid Metabolism: Insights from Oral Exposure Studies DOI

Peng Chen Zheng,

Xin Pan, Yi Zhou

et al.

Environmental Pollution, Journal Year: 2025, Volume and Issue: unknown, P. 126157 - 126157

Published: March 1, 2025

Language: Английский

Citations

0
Rising Concern About the Carcinogenetic Role of Micro-Nanoplastics DOI Open Access
Lorenzo Ruggieri, Ottavia Amato, Cristina Marrazzo

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 26(1), P. 215 - 215

Published: Dec. 30, 2024

In recent years, awareness regarding micro-nanoplastics’ (MNPs) potential effects on human health has progressively increased. Despite a large body of evidence the origin and distribution MNPs in environment, their impact remains to be determined. this context, there is major need address carcinogenic risks, since could hypothetically mediate direct indirect effects, latter mediated by particle-linked chemical carcinogens. Currently, field scarce heterogeneous, but reported increased incidence malignant tumors among younger populations, together with ubiquitous environmental abundance MNPs, are rising global concern possible role development progression cancer. review, we provide an overview currently available eco-toxicology, as well methods for identification characterization MNP particulates health-associated focus addition, suggest routes future research order unravel carcinogenetic exposure understand prognostic preventive implications intratumoral MNPs.

Language: Английский

Citations

0