Multigenerational Consequences of Prenatal Exposure to Benzophenone-3 Demonstrate Sex- and Region-Dependent Neurotoxic and Pro-Apoptotic Effects in Mouse Brain DOI Creative Commons
Karolina Przepiórska,

Andrzej Łach,

Bernadeta Angelika Pietrzak

et al.

Toxics, Journal Year: 2024, Volume and Issue: 12(12), P. 906 - 906

Published: Dec. 13, 2024

Benzophenone-3 (BP-3), commonly used as a UV filter in personal care products and stabilizer, is an alleged endocrine disruptor with potential neurodevelopmental impacts. Despite its abundance the environment, studies on effect brain development are scarce, especially terms of multigenerational impact. In this work, for first time, we examined neurotoxic pro-apoptotic effects BP-3 mouse regions (cerebral cortex hippocampus) both (F1) second (F2) generations after maternal exposure to environmentally relevant levels. We found disregulated markers cell damage (LDH, H2O2, caspase-3 -8) observed increased expression Fas/FAS or Fasl/FASL. disrupted BAX/BCL2 pathway, showing stronger F1 than F2 generation, dominance extrinsic pathway (FAS, FASL, caspase-8) over intrinsic one (BAX, BCL2), suggesting that BP-3-induced apoptosis primarily operates via could impair homeostasis across generations. This study underscores increase risks associated neurodevelopment highlights importance understanding long-term effects.

Language: Английский

The Toxicological Impact of the Ultraviolet Filter Oxybenzone on Antioxidant Profiles in In Virto Cultures of Lentinula edodes DOI Creative Commons
Agata Kryczyk‐Poprawa,

Adrián Sánchez-Hidalgo,

Wojciech Baran

et al.

Toxics, Journal Year: 2025, Volume and Issue: 13(3), P. 145 - 145

Published: Feb. 20, 2025

A detailed understanding of the toxic effects organic UV filters, such as oxybenzone, on living organisms is crucial for assessing feasibility bioremediation methods. Due to widespread use oxybenzone an ultraviolet filter in sunscreens, it has become emerging contaminant concern environment. This extends fungi, which have potential neutralize a wide variety xenobiotics released into The primary objective study was elucidate alterations antioxidant profiles white-rot fungus Lentinula edodes response exposure. Samples with at final concentration 0.1 mg mL−1 were cultured vitro mycelium L. 14 days. contents following compounds assessed: indole derivatives (6-methyl-D,L-tryptophan, tryptophan), ergothioneine, and phenolic acid (p-hydroxybenzoic acid), well lovastatin ergosterol. addition negatively affected biomass growth, reducing from 3.205 ± 0.4022 g 0.5803 0.1019 g. considerable reduction amounts found medium after incubation (from 25 0.2993 0.1934 mg). After lyophilization, contained 1.1591 0.0323 oxybenzone. Additionally, eleven biotransformation products assessed samples using UPLC-Q ToF. incubation, transformation identified based monoisotopic molecular mass fragmentation spectra. observed increase content some antioxidants, e.g., while others, lovastatin, suggests that impact profile cultures complex. Marked growth suggest toxicological risk associated contributes environmental filters emphasizes need safer alternatives.

Language: Английский

Citations

1
Migration of Chemical Compounds from Packaging Materials into Packaged Foods: Interaction, Mechanism, Assessment, and Regulations DOI Creative Commons
Rakesh Kumar Gupta, Sunil Pipliya, Sangeetha Karunanithi

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(19), P. 3125 - 3125

Published: Sept. 30, 2024

The migration of chemical compounds from packaging polymers to food presents a multifaceted challenge with implications for safety and public health. This review explores the interaction between materials products, focusing on permeation, migration, sorption processes. different mechanisms contact gas phase penetration set-off condensation/distillation have been discussed comprehensively. major migrating are plasticizers, nanoparticles, antioxidants, light stabilizers, thermal monomers, oligomers, printing inks, adhesives, posing potential health risks due their association endocrine disruption carcinogenic effects. Advanced analytical methods help in monitoring migrated compounds, facilitating compliance regulatory standards. Regulatory agencies enforce guidelines limit prompting development barrier coatings safer alternatives. Furthermore, there is need decipher mechanism mitigating it along advancements techniques compounds.

Language: Английский

Citations

7
Microplastics and volatile organic compounds released from face masks after disinfection: Layers and materials differences DOI
Zongyi Tan, Haiyang Deng,

Huali Ou

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 917, P. 170286 - 170286

Published: Jan. 26, 2024

Language: Английский

Citations

4
Granulated rubber in playgrounds and sports fields: a potential source of atmospheric plastic-related contaminants and plastic additives after runoff events DOI Creative Commons
Katerina Savva, Marta Llorca,

Xavier Borrell

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 479, P. 135697 - 135697

Published: Aug. 28, 2024

The use of "crumb rubber" coming from recycling materials in outdoor floors like playgrounds has been a frequent practice during the last years. However, these surfaces are object abrasion and weathering being potential source micro nanoplastics (MNPLs) to atmosphere human exposure them. Our main goal expose different crumb rubber summer effects. released inhalable fractions were sampled for two months with passive samplers composition MNPLs plastic additives (organic inorganic) evaluated. ecotoxicological effects leached emulating runoff events was evaluated freshwater crustacean Daphnia magna green algae Chlorella vulgaris. analysis showed presence polyethylene, polypropylene, polybutadiene, polysiloxanes polybutylene at concentrations up 30,426 ng/m

Language: Английский

Citations

3
Contaminants of Emerging Concern in Commercial Tomatoes: Influence of Farming Practices and Geographical Origin on Contaminant Profiles DOI
Juan Cruz Carrizo,

Clara Canals Martí,

M. Silvia Díaz˗Cruz

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Les analyses bibliographiques internationales de la veille 365SFD – sélection troisième trimestre 2024 DOI

M. Reverte,

C. Jaulent-Darmaisin,

A. Petit

et al.

Annales de Dermatologie et de Vénéréologie - FMC, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Citations

0
Multi-target analysis of synthetic phenolic compounds in human blood DOI Creative Commons
Josefin Engelhardt, Ioannis Athanassiadis, P.E.G. Leonards

et al.

Talanta, Journal Year: 2025, Volume and Issue: 292, P. 127899 - 127899

Published: March 5, 2025

Language: Английский

Citations

0
First Evidence in the Association of Phenolic Endocrine-Disrupting Chemicals with Secondary Non-Alcoholic Fatty Liver Disease: A Case-Control Study in South China DOI

Henglin Zhang,

Shuai Feng, Shiming Song

et al.

Environmental Pollution, Journal Year: 2025, Volume and Issue: unknown, P. 126086 - 126086

Published: March 1, 2025

Language: Английский

Citations

0
Decidual Disrupting Effects of Low-Dose Benzophenone-Type UV Filters in Human Endometrial Stromal Cells via ER/PR/FOXO1 Signaling DOI
Tingjie Zhan,

Lilai Shen,

Yuyao Zhang

et al.

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Exposure to endocrine disrupting chemicals (EDCs), particularly benzophenone (BP)-type UV filters, has been epidemiologically linked endometrium-related reproductive risks in women. However, their effects on hormone-driven endometrial events and key receptor signaling at the human cellular level remain unexplored. Herein, using primary stromal cells (HESCs), we investigated of five BP congeners deciphered underlying mechanism decidualization, a functional change endometrium preparing for pregnancy. BP-8, its two metabolites, BP-3, BP-1 10 nM significantly disrupted progesterone-dependent decidualization HESCs, marked by 1.5–1.8-fold 2.2–2.6-fold upregulation IGFBP-1 LEFTY, respectively. Decidual transcriptional activators, WNT-FOXO1, were induced BPs, which are implicated G2 phase cell arrest (from 3.26% 8.93%) apoptosis 12.29% 25.61%). Mechanistically, inhibition estrogen α (ERα) effectively alleviated these decidual effects. BPs increased transcription ERα progesterone (PR) enhanced nuclear translocation interaction between PR during decidualization. The ERα-mediated enhancement activity was further validated response element-luciferase transfected cells. Collectively, our findings elucidate molecular pathway through disrupt via ERα/PR/FOXO1, providing critical mechanistic insights risk assessment structurally related EDCs.

Language: Английский

Citations

0
Are Sunscreens Safe? DOI Creative Commons

Metin Özaslan

IntechOpen eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Ultraviolet (UV) light is one of the main environmental factors that can lead to skin cancers, photoaging, and DNA mutations. Sunscreens contain organic, inorganic, naturally derived filters absorb or reflect UV rays. Recently, concerns have been raised over safety sunscreen ingredients. However, systemic absorption long-term these ingredients remain controversial. The FDA has reported some organic enter bloodstream may potential endocrine-disrupting effects. In particular, oxybenzone octinoxate are banned in regions due hormonal dysfunction toxicity. Octocrylene found produce benzophenone time toxic While available data support benefits sunscreens, there a lack studies. More comprehensive toxicological analyses regulatory standards needed assess effects sunscreens on both human health environment.

Language: Английский

Citations

0