Synthesis and Antioxidant Activity of Caffeic Acid Derivatives DOI Creative Commons
Katarzyna Sidoryk, Anna Jaromin, Nina Filipczak

et al.

Molecules, Journal Year: 2018, Volume and Issue: 23(9), P. 2199 - 2199

Published: Aug. 30, 2018

A series of caffeic acid derivatives were synthesized via a modified Wittig reaction which is very important tool in organic chemistry for the construction unsaturated carbon–carbon bonds. All reactions performed water medium at 90 °C. The aqueous worked best when one unprotected hydroxyl group was present phenyl ring. olefinations conditions also conducted with good yields presence two groups. When number groups increased to three, worse, and 12, 13, 18 obtained 74%, 37%, 70% yields, respectively. Nevertheless, using as essential an elegant one-pot synthesis greener method, can be safe alternative implementation chemistry. compounds tested their antioxidant activity, showed highest activities. Moreover, all displayed no cytotoxicity, therefore used pharmaceutical or cosmetic industry.

Language: Английский

Polyphenols as Antioxidants for Extending Food Shelf-Life and in the Prevention of Health Diseases: Encapsulation and Interfacial Phenomena DOI Creative Commons
Marlene Costa, Zerrin Sezgin Bayındır, Sonia Losada‐Barreiro

et al.

Biomedicines, Journal Year: 2021, Volume and Issue: 9(12), P. 1909 - 1909

Published: Dec. 14, 2021

Toxicity caused by the exposure to human-made chemicals and environmental conditions has become a major health concern because they may significantly increase formation of reactive oxygen species (ROS), negatively affecting endogenous antioxidant defense. Living systems have evolved complex mechanisms protect cells from oxidative conditions. Although stress contributes various pathologies, intake molecules such as polyphenols, obtained natural sources, limit their effects antimicrobial properties against lipid peroxidation broad range foodborne pathogens. Ingestion polyphenol-rich foods, fruits vegetables, help reduce harmful ROS, but use supramolecular nanomaterials delivery emerged an efficient method improve pharmacological therapeutic effects. Suitable exogenous polyphenolic antioxidants should be readily absorbed delivered sites where pathological damage take place, for instance, intracellular locations. Many potential poor bioavailability, can encapsulated ideal solubility permeability profile. Development effective strategies requires creation new nanoscale drug stress. In this review we provide overview process, highlight some discuss role polyphenols bioactives in controlling overproduction ROS bacterial fungal growth, paying special attention encapsulation suitable location colloidal interfaces play crucial role.

Language: Английский

Citations

58
Synthesis of silver nanoparticles using Myristica fragrans seed shell: Assessment of antibacterial, antioxidant properties and photocatalytic degradation of dyes DOI
Teema Thomas, Arun Kumar Thalla

Journal of environmental chemical engineering, Journal Year: 2023, Volume and Issue: 11(2), P. 109585 - 109585

Published: Feb. 26, 2023

Language: Английский

Citations

28
Improved functionality and safety of peptides by the formation of peptide-polyphenol complexes DOI

Duanquan Lin,

Le‐Chang Sun,

W. Huo

et al.

Trends in Food Science & Technology, Journal Year: 2023, Volume and Issue: 141, P. 104193 - 104193

Published: Oct. 4, 2023

Language: Английский

Citations

25
Fisetin Alleviates d-Galactose-Induced Senescence in C2C12 Myoblasts: Metabolic and Gene Regulatory Mechanisms DOI
Yue Zhang,

Wenfang Wu,

Caihua Huang

et al.

Journal of Proteome Research, Journal Year: 2025, Volume and Issue: 24(2), P. 834 - 849

Published: Jan. 8, 2025

Skeletal muscle aging poses a major threat to the health and quality of life elderly individuals. Fisetin, natural polyphenolic compound, exhibits various biological activities; however, its role in preventing skeletal cell is still unclear. This study aimed elucidate effects fisetin on using d-galactose-induced C2C12 myoblast senescence model. Fisetin treatment effectively ameliorated damage restored cellular functionality by improving viability, reducing accumulation marker enzyme SA-β-gal, decreasing expression key proteins, p16 p53. NMR-based metabolomics RNA-seq transcriptomics analyses revealed that regulates several critical metabolic pathways, including glutathione metabolism, glycine, serine threonine as well taurine hypotaurine metabolism. regulation led restoration amino acid stabilization energy homeostasis, preservation membrane integrity. In addition, inhibited calcium signaling JAK-STAT reduced stress responses reversed senescence-induced cycle arrest. Together, these findings highlight potential therapeutic agent combat restore offering promising avenue for development antiaging treatments degeneration.

Language: Английский

Citations

1
Synthesis and Antioxidant Activity of Caffeic Acid Derivatives DOI Creative Commons
Katarzyna Sidoryk, Anna Jaromin, Nina Filipczak

et al.

Molecules, Journal Year: 2018, Volume and Issue: 23(9), P. 2199 - 2199

Published: Aug. 30, 2018

A series of caffeic acid derivatives were synthesized via a modified Wittig reaction which is very important tool in organic chemistry for the construction unsaturated carbon–carbon bonds. All reactions performed water medium at 90 °C. The aqueous worked best when one unprotected hydroxyl group was present phenyl ring. olefinations conditions also conducted with good yields presence two groups. When number groups increased to three, worse, and 12, 13, 18 obtained 74%, 37%, 70% yields, respectively. Nevertheless, using as essential an elegant one-pot synthesis greener method, can be safe alternative implementation chemistry. compounds tested their antioxidant activity, showed highest activities. Moreover, all displayed no cytotoxicity, therefore used pharmaceutical or cosmetic industry.

Language: Английский

Citations

64