Encapsulation of Bioactive Compounds for Food and Agricultural Applications

Polymers, Journal Year: 2022, Volume and Issue: 14(19), P. 4194 - 4194

Published: Oct. 6, 2022

This review presents an updated scenario of findings and evolutions encapsulation bioactive compounds for food agricultural applications. Many polymers have been reported as encapsulated agents, such sodium alginate, gum Arabic, chitosan, cellulose carboxymethylcellulose, pectin, Shellac, xanthan gum, zein, pullulan, maltodextrin, whey protein, galactomannan, modified starch, polycaprolactone, caseinate. The main methods investigated in the study include both physical chemical ones, freeze-drying, spray-drying, extrusion, coacervation, complexation, supercritical anti-solvent drying. Consequently, area, peptides, vitamins, essential oils, caffeine, plant extracts, fatty acids, flavonoids, carotenoids, terpenes are encapsulated. In lipids, phytotoxins, medicines, vaccines, hemoglobin, microbial metabolites Most scientific investigations one or more objectives, to improve stability formulated systems, increase release time, retain protect active properties, reduce lipid oxidation, maintain organoleptic present bioactivities even extreme thermal, radiation, pH conditions. Considering increasing worldwide interest biomolecules modern sustainable agriculture, can be efficient formulation biofungicides, biopesticides, bioherbicides, biofertilizers. With this review, it is inferred that current indicates production by scales techno-economic feasibilities. Technology Readiness Level (TRL) most going beyond TRL 6, which knowledge gathered allows having a functional prototype representative model technologies presented review.

Language: Английский

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Antioxidant Activity, Metabolism, and Bioavailability of Polyphenols in the Diet of Animals

Antioxidants, Journal Year: 2023, Volume and Issue: 12(6), P. 1141 - 1141

Published: May 23, 2023

As the world’s population grows, so does need for more and animal feed. In 2006, EU banned use of antibiotics other chemicals in order to reduce chemical residues food consumed by humans. It is well known that oxidative stress inflammatory processes must be combated achieve higher productivity. The adverse effects pharmaceuticals synthetic compounds on health product quality safety have increased interest phytocompounds. With plant polyphenols nutrition, they are gaining attention as a supplement Livestock feeding based sustainable, environmentally friendly approach (clean, safe, green agriculture) would also win–win farmers society. There an increasing producing healthier products origin with ratio polyunsaturated fatty acids (PUFAs) saturated modulating nutrition. Secondary metabolites (polyphenols) essential physiology involved various functions such growth, pigmentation, resistance pathogenic organisms. Polyphenols exogenous antioxidants act one first lines cell defense. Therefore, discoveries intracellular antioxidant activity contributed significantly improvement activity, prevent damage eliminate excessively produced free radicals. To welfare, medicines, increase origin, addition research breeding can practised part free-choice

Language: Английский

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Polyphenols in Health and Disease: Gut Microbiota, Bioaccessibility, and Bioavailability

Compounds, Journal Year: 2023, Volume and Issue: 3(1), P. 40 - 72

Published: Jan. 5, 2023

Polyphenolic compounds (PC) are among the most abundant secondary metabolites in nature. They widely distributed world and can be found fruits, cereals, tea, coffee, beverages. Due to their structural diversity, polyphenols have many different properties biological effects. resistant acid of gastric tract, very few hydrolysed or absorbed stomach. Significant portions ingested reach large intestine interact with local bacteria, so-called gut microbiota. Epidemiological studies confirm that moderate prolonged intake foods rich could prevent development cancer chronic diseases, such as cardiovascular, neurodegenerative, type 2 diabetes, obesity. The current work aims provide an updated overview on nature occurrence polyphenols, quantification methods, bioaccessibility bioavailability, impact human health, namely through interactions

Language: Английский

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Anti-Inflammatory and Antioxidative Phytogenic Substances against Secret Killers in Poultry: Current Status and Prospects

Veterinary Sciences, Journal Year: 2023, Volume and Issue: 10(1), P. 55 - 55

Published: Jan. 14, 2023

Chronic stress is recognized as a secret killer in poultry. It associated with systemic inflammation due to cytokine release, dysbiosis, and the so-called leaky gut syndrome, which mainly results from oxidative reactions that damage barrier function of cells lining wall. Poultry, especially genetically selected broiler breeds, frequently suffer these chronic symptoms when exposed multiple stressors their growing environments. Since inflammatory damages are multi-stage long-term processes, overshooting immune down-stream effects also negatively affect animal's microbiota, finally impair its performance commercial value. Means counteract poultry other animals are, therefore, highly welcome. Many phytogenic substances, including flavonoids phenolic compounds, known exert anti-inflammatory antioxidant effects. In this review, firstly, main poultry, such heat stress, mycotoxins, dysbiosis diets contain oxidized lipids trigger inflammation, discussed, along key transcription factors involved related signal transduction pathways. Secondly, most promising substances current applications ameliorate highlighted.

Language: Английский

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Polyphenols as Antioxidant/Pro-Oxidant Compounds and Donors of Reducing Species: Relationship with Human Antioxidant Metabolism

Processes, Journal Year: 2023, Volume and Issue: 11(9), P. 2771 - 2771

Published: Sept. 16, 2023

In this review, we have focused mainly on the study of their antioxidant and pro-oxidant capacity, analysis oxidation catechol group to o-quinone. The redox balance established between different oxidase reductase enzymes generates reducing species, H+ e−, allows polyphenolic groups quinones be reversible. This continuous these nucleophilic electrophilic substances activation NRF2/ARE axis, which regulates cellular responses against oxidative stress, as well cell proliferation. Understanding ambivalent character polyphenols, can act simultaneously antioxidants pro-oxidants, will allow design specific therapies that serve science medicine in tasks.

Language: Английский

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Antioxidant Metabolism Pathways in Vitamins, Polyphenols, and Selenium: Parallels and Divergences

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(5), P. 2600 - 2600

Published: Feb. 23, 2024

Free radicals (FRs) are unstable molecules that cause reactive stress (RS), an imbalance between oxygen and nitrogen species in the body its ability to neutralize them. These generated by both internal external factors can damage cellular lipids, proteins, DNA. Antioxidants prevent or slow down oxidation process interrupting transfer of electrons substances agents. This is particularly important at level because reactions lead formation FR contribute various diseases. As we age, RS accumulates leads organ dysfunction age-related disorders. Polyphenols; vitamins A, C, E; selenoproteins possess antioxidant properties may have a role preventing treating certain human diseases associated with RS. In this review, explore current evidence on potential benefits dietary supplementation investigate intricate connection SIRT1, crucial regulator aging longevity; transcription factor NRF2; polyphenols, vitamins, selenium. Finally, discuss positive effects molecules, such as reducing RS, their slowing several

Language: Английский

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Polyphenols in Ruminant Nutrition and Their Effects on Reproduction

Antioxidants, Journal Year: 2022, Volume and Issue: 11(5), P. 970 - 970

Published: May 14, 2022

The feeding of domestic animals with diets in which polyphenols are present is increasingly attracting the attention nutritionists and scientists. This review summarizes knowledge regarding polyphenols’ possible positive negative effects their bioavailability. bioavailability substances a prerequisite for any postabsorption effect vivo. Positive properties have been confirmed previous studies on rich polyphenols, such as secondary metabolites plants. Free radicals formed every organism, leading to oxidative stress. highly reactive molecules can react cells macromolecules cause damage, including reproductive cells. Some at specific concentrations antioxidant that positively affect animal reproduction by improving quality male female gametes. intake phytoestrogens mimic estrogen function induce various pathological conditions tract, ovarian, fallopian, uterine dysfunction. metabolism genistein daidzein yields equol p-phenyl-phenol, decline cow fertilization. findings so far confirm numerous questions still need be answered. points out importance using both benificial some unfavorable diets.

Language: Английский

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Electrophilic Compounds in the Human Diet and Their Role in the Induction of the Transcription Factor NRF2

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(6), P. 3521 - 3521

Published: March 20, 2024

The phrase “Let food be thy medicine…” means that can a form of medicine and food; in other words, the diet we eat have significant impact on our health well-being. Today, this is gaining prominence as more scientific evidence suggests one’s help prevent treat disease. A rich fruits, vegetables, whole grains, lean protein reduce risk heart disease, cancer, diabetes, problems and, hand, processed foods, added sugars, saturated fats increase same diseases. Electrophilic compounds health, they are molecules covalently modify cysteine residues present thiol-rich Keap1 protein. These bind to activate NRF2, which promotes its translocation nucleus binding DNA ARE region, triggering antioxidant response protecting against oxidative stress. include polyphenols flavonoids nucleophilic but converted electrophilic quinones by metabolic enzymes such polyphenol oxidases (PPOs) sulfur foods Brassica genus (broccoli, cauliflower, cabbage, Brussel sprouts, etc.) garlic. This review summarizes current knowledge subject.

Language: Английский

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A Comprehensive Review on Anti-Inflammatory Response of Flavonoids in Experimentally-Induced Epileptic Seizures

Brain Sciences, Journal Year: 2023, Volume and Issue: 13(1), P. 102 - 102

Published: Jan. 5, 2023

Flavonoids, a group of natural compounds with phenolic structure, are becoming popular as alternative medicines obtained from plants. These reported to have various pharmacological properties, including attenuation inflammatory responses in multiple health issues. Epilepsy is disorder the central nervous system implicated activation cascade brain. The aim present study was summarize role neuroinflammatory mediators onset and progression epilepsy, and, thereafter, discuss flavonoids their classes, biological properties. Further, we highlighted modulation anti-inflammatory achieved by these substances different forms evident preclinical studies executed on epilepsy models. Overall, review summarizes available evidence potential epilepsy.

Language: Английский

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Anti-Inflammatory Activity of Olive Oil Polyphenols—The Role of Oleacein and Its Metabolites

Biomedicines, Journal Year: 2022, Volume and Issue: 10(11), P. 2990 - 2990

Published: Nov. 21, 2022

The anti-inflammatory potential of oleacein, the main polyphenolic compound found in olive oil, and its metabolites were characterized by their effects on RAW 264.7 macrophages challenged with lipopolysaccharide (LPS), ability to inhibit enzymes arachidonic acid metabolism a key role synthesis pro-inflammatory lipid mediators. Oleacein at 12.5 µM significantly decreased amount L-citrulline ●NO generated LPS-stimulated macrophages. Hydroxytyrosol, hydroxytyrosol acetate sulfate also able reduce cellular ●NO, although lesser extent. In contrast, glucuronide did not show detectable effects. was coupled PLA2 + 5-LOX enzyme system (IC50 = 16.11 µM), as well 45.02 µM). Although lower activity, both capable inhibiting these concentration 100 µM. None other tested showed capacity enzymes. all compounds, including glucuronides metabolites, remarkable cyclooxygenase isoforms, COX-1 COX-2, IC50 values than 3 Therefore, oleacein have modulate ●NO- acid-dependent inflammatory cascades, contributing activity associated oil polyphenols.

Language: Английский

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