Fruits, vegetables, and health: A comprehensive narrative, umbrella review of the science and recommendations for enhanced public policy to improve intake

Critical Reviews in Food Science and Nutrition, Journal Year: 2019, Volume and Issue: 60(13), P. 2174 - 2211

Published: July 3, 2019

Fruit and vegetables (F&V) have been a cornerstone of healthy dietary recommendations; the 2015-2020 U.S. Dietary Guidelines for Americans recommend that F&V constitute one-half plate at each meal. include diverse collection plant foods vary in their energy, nutrient, bioactive contents. potential health-promoting effects beyond providing basic nutrition needs humans, including role reducing inflammation preventive on various chronic disease states leading to decreases years lost due premature mortality lived with disability/morbidity. Current global intakes are well below recommendations. Given importance health, public policies promote interventions help increase intake warranted. This externally commissioned expert comprehensive narrative, umbrella review summarizes up-to-date clinical observational evidence current F&V, discusses available health benefits offers implementation strategies ensure messaging is reflective science. demonstrates provide helping achieve nutrient requirements humans. The scientific recommendations consumption prevention strong. suggests strongest relation CVDs, noting nonlinear threshold effect 800 g per day (i.e., about 5 servings day). A growing body (mostly small RCTs) specific certain states; however, more research individual still needed many areas. Data from systematic reviews mostly studies cited this report also support types particularly cruciferous vegetables, dark-green leafy citrus fruits, dark-colored berries, which superior biomarkers, surrogate endpoints, outcomes disease.

Language: Английский

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Roles of flavonoids against coronavirus infection

Chemico-Biological Interactions, Journal Year: 2020, Volume and Issue: 328, P. 109211 - 109211

Published: July 28, 2020

Language: Английский

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The Cancer Prevention, Anti-Inflammatory and Anti-Oxidation of Bioactive Phytochemicals Targeting the TLR4 Signaling Pathway

International Journal of Molecular Sciences, Journal Year: 2018, Volume and Issue: 19(9), P. 2729 - 2729

Published: Sept. 12, 2018

Toll-like receptors (TLRs) are a well-known family of pattern recognition that play an important role in host immune system. TLR triggering leads to the induction pro-inflammatory cytokines and chemokines, driving activation both innate adaptive immunity. Recently, increasing number studies have shown link between TLRs cancer. Among them, toll-like receptor 4 (TLR4) signaling pathway is associated with inflammatory response cancer progression. Dietary phytochemicals potential modulators immunological status various pharmacological properties including anti-cancer, anti-oxidant anti-inflammatory. Curcumin, 6-gingerol, 6-shogaol, 1-dehydro-10-gingerdione, epigallocatechin gallate (EGCG), luteolin, quercetin, resveratrol, caffeic acid phenethyl ester, xanthohumol, genistein, berberine, sulforaphane can inhibit TLR4 activation. The aim present review describe We further introduce bioactive anti-inflammation chemoprevention by inhibiting

Language: Английский

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Nutrition, Physical Activity, and Other Lifestyle Factors in the Prevention of Cognitive Decline and Dementia

Nutrients, Journal Year: 2021, Volume and Issue: 13(11), P. 4080 - 4080

Published: Nov. 15, 2021

Multiple factors combined are currently recognized as contributors to cognitive decline. The main independent risk factor for impairment and dementia is advanced age followed by other determinants such genetic, socioeconomic, environmental factors, including nutrition physical activity. In the next decades, a rise in cases expected due largely aging of world population. There no hitherto effective pharmaceutical therapies treat age-associated dementia, which underscores crucial role prevention. A relationship among diet, activity, lifestyle with function has been intensively studied mounting evidence supporting these development decline chief cause disability globally. Several dietary patterns, foods, nutrients have investigated this regard, some encouraging disappointing results. This review presents current effects components, supplements, sleep social engagement on prevention or delay onset age-related dementia.

Language: Английский

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Beneficial Effects of Citrus Flavonoids on Cardiovascular and Metabolic Health

Oxidative Medicine and Cellular Longevity, Journal Year: 2019, Volume and Issue: 2019, P. 1 - 19

Published: March 10, 2019

The prevalence of cardiovascular disease (CVD) is increasing over time. CVD a comorbidity in diabetes and contributes to premature death. Citrus flavonoids possess several biological activities have emerged as efficient therapeutics for the treatment CVD. scavenge free radicals, improve glucose tolerance insulin sensitivity, modulate lipid metabolism adipocyte differentiation, suppress inflammation apoptosis, endothelial dysfunction. intake citrus has been associated with improved outcomes. Although exerted multiple beneficial effects, their mechanisms action are not completely established. In this review, we summarized recent findings advances understanding underlying protective effects against oxidative stress, inflammation, diabetes, dyslipidemia, dysfunction, atherosclerosis. Further studies clinical trials assess efficacy explore mechanism(s) recommended.

Language: Английский

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Quercetin alleviates rat osteoarthritis by inhibiting inflammation and apoptosis of chondrocytes, modulating synovial macrophages polarization to M2 macrophages

Free Radical Biology and Medicine, Journal Year: 2019, Volume and Issue: 145, P. 146 - 160

Published: Sept. 21, 2019

Language: Английский

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Flavonoids as Therapeutic Agents in Alzheimer’s and Parkinson’s Diseases: A Systematic Review of Preclinical Evidences

Oxidative Medicine and Cellular Longevity, Journal Year: 2018, Volume and Issue: 2018(1)

Published: Jan. 1, 2018

Alzheimer’s and Parkinson’s diseases are considered the most common neurodegenerative disorders, representing a major focus of neuroscience research to understanding cellular alterations pathophysiological mechanisms involved. Several natural products, including flavonoids, able cross blood‐brain barrier known for their central nervous system‐related activity. Therefore, studies being conducted with these chemical constituents analyze activities in slowing down progression diseases. The present systematic review summarizes pharmacological effects flavonoids animal models A PRISMA model was utilized this search. following databases: PubMed, Web Science, BIREME, Science Direct. Based on inclusion criteria, 31 articles were selected discussed review. listed revealed that main targets action disease therapy reduction reactive oxygen species amyloid beta‐protein production, while oxidative potential activation neuronal death. Results showed variety is studied can be promising development new drugs treat Moreover, it possible verify there lack translational clinical evidence compounds.

Language: Английский

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Plant-Based Dietary Patterns, Plant Foods, and Age-Related Cognitive Decline

Advances in Nutrition, Journal Year: 2019, Volume and Issue: 10, P. S422 - S436

Published: July 4, 2019

Language: Английский

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Conventional and Emerging Extraction Processes of Flavonoids

Processes, Journal Year: 2020, Volume and Issue: 8(4), P. 434 - 434

Published: April 7, 2020

Flavonoids are a group of plant constituents called phenolic compounds and correspond to the nonenergy part human diet. found in vegetables, seeds, fruits, beverages such as wine beer. Over 7000 flavonoids have been identified they considered substances with beneficial action on health, particularly multiple positive effects because their antioxidant free radical scavenging action. Although several studies indicate that some provident actions, occur only at high doses, confirming most investigations existence anti-inflammatory effects, antiviral or anti-allergic, protective role against cardiovascular disease, cancer, various pathologies. generally removed by chemical methods using solvents traditional processes, which besides being expensive, involve long periods time affect bioactivity compounds. Recently, efforts develop biotechnological strategies reduce eliminate use toxic reported, reducing processing maintaining In this paper, we review, analyze, discuss methodologies for recovery/extraction from agro-industrial residues, describing advances challenges topic.

Language: Английский

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Oxidative stress, hormones, and effects of natural antioxidants on intestinal inflammation in inflammatory bowel disease

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: Aug. 28, 2023

Inflammatory bowel disease (IBD) is a chronic, relapsing gastrointestinal (GI) disorder characterized by intestinal inflammation. The etiology of IBD multifactorial and results from complex interplay between mucosal immunity, environmental factors, host genetics. Future therapeutics for GI disorders, including IBD, that are driven oxidative stress require greater understanding the cellular molecular mechanisms mediated reactive oxygen species (ROS). In tract, stressors include infections pro-inflammatory responses, which boost ROS generation promoting production cytokines. Nuclear factor kappa B (NF-κB) nuclear erythroid 2–related 2 (Nrf2) represent two important signaling pathways in immune cells regulate numerous physiological processes, anti-inflammatory antioxidant activities. Natural compounds exhibit scavenging increase defense capacity to inhibit pro-oxidative enzymes, may be useful treatment. this review, we discuss various polyphenolic substances (such as resveratrol, curcumin, quercetin, green tea flavonoids, caffeic acid phenethyl ester, luteolin, xanthohumol, genistein, alpinetin, proanthocyanidins, anthocyanins, silymarin), phenolic thymol, alkaloids such berberine, storage polysaccharides tamarind xyloglucan, other phytochemicals represented isothiocyanate sulforaphane food/spices ginger, flaxseed oil), well hormones like melatonin target reduce inflammation occurring with IBD.

Language: Английский

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