Impact of nutraceuticals and dietary supplements on mitochondria modifications in healthy aging: a systematic review of randomized controlled trials DOI
Lorenzo Lippi, Francesca Uberti, Arianna Folli

et al.

Aging Clinical and Experimental Research, Journal Year: 2022, Volume and Issue: 34(11), P. 2659 - 2674

Published: Aug. 3, 2022

Language: Английский

Healthy Aging and Dietary Patterns DOI Open Access
Ligia J. Domínguez, Nicola Veronese,

Eleonora Baiamonte

et al.

Nutrients, Journal Year: 2022, Volume and Issue: 14(4), P. 889 - 889

Published: Feb. 20, 2022

A number of factors contribute to the complex process aging, which finally define whether someone will or not develop age-associated chronic diseases in late life. These determinants comprise genetic susceptibility as well various behavioral, environmental, and dietary factors, all have been shown influence specific pathways regulating aging extension life, makes longevity a multidimensional phenomenon. Although "miraculous elixir" "nutrition pill" are plausible, researchers agree on notion that nutritional major impact risk non-communicable mortality. In recent years nutrition research relation health outcomes has considerably changed from focusing exclusively single nutrients considering combinations foods rather than isolation. is scientifically valid providing crucial evidence mechanisms by impacts health, switch targeting multifaceted synergistic interplay among nutrients, other constituents, whole foods, promoted emerging interest actions total patterns. This narrative review aims describe some patterns with associations reduction incidence allowing older adults live long-lasting healthier confirming powerful can exert healthy aging.

Language: Английский

Citations

92

Mediterranean diet in the management and prevention of obesity DOI Creative Commons
Ligia J. Domínguez, Nicola Veronese,

Giovanna Di Bella

et al.

Experimental Gerontology, Journal Year: 2023, Volume and Issue: 174, P. 112121 - 112121

Published: Feb. 17, 2023

The current pandemic of obesity represents a major global public health problem, mainly due to its association with chronic non-communicable disabling conditions and increased mortality. Population aging increases the chances diseases allowing longer exposure risk factors for these conditions. Obesity is factor contributing pathological aging. Numerous epidemiological studies have shown that death cardiovascular disease cancer progressively as overweight rise. Nutrition research now focused on effects combinations foods in dietary patterns instead those single nutrients or foods. model largest body evidence benefit traditionally followed by inhabitants some Mediterranean countries. There confirming inverse adhering diet obesity. Four meta-analyses randomized controlled trials, including up 16 greater reduction weight BMI MedDiet compared other diets, while meta-analysis 7 prospective cohort studies, found reduced becoming obese gaining over time associated higher adherence MedDiet. This narrative review examines reporting associations overweight/obesity age-associated related

Language: Английский

Citations

92

Sporting Mind: The Interplay of Physical Activity and Psychological Health DOI Creative Commons
Alexandra Martín-Rodríguez,

Laura Augusta Gostian-Ropotin,

Ana Isabel Beltrán-Velasco

et al.

Sports, Journal Year: 2024, Volume and Issue: 12(1), P. 37 - 37

Published: Jan. 22, 2024

The symbiotic relationship between sports practice and psychological well-being has, in recent times, surged to the forefront of academic public attention. aim this narrative review is comprehensively explore intricate pathways linking physical engagement its subsequent impacts on mental health synthesize multifarious effects health, offering insights for integrating strategies enhance well-being. From neurobiological underpinnings therapeutic applications, comprehensive manuscript provides an in-depth dive into multifaceted world psychology. Highlighting evidence-based interventions, aspires offer actionable practitioners, athletes, individuals alike, advocating a holistic approach This highlights profound impact emphasizing role emotional regulation, resilience, cognitive function, treating conditions. It details how induce neurochemical changes, brain functions like memory learning, aid against decline. also notes benefits regular exercise mood improvement, stress management, social skill enhancement, particularly when combined with mindfulness practices. underscores importance considering cultural gender perspectives psychology, integrated physical-psychological promote overall

Language: Английский

Citations

87

Diet in the Prevention of Alzheimer’s Disease: Current Knowledge and Future Research Requirements DOI Open Access

Oliwia Stefaniak,

Małgorzata Dobrzyńska, Slawomira Drzymała-Czyż

et al.

Nutrients, Journal Year: 2022, Volume and Issue: 14(21), P. 4564 - 4564

Published: Oct. 30, 2022

Alzheimer’s disease is a progressive brain that becoming major health problem in today’s world due to the aging population. Despite it being widely known diet has significant impact on prevention and progression of disease, literature data are still scarce controversial. The application principles rational nutrition for elderly suggested disease. should be rich neuroprotective nutrients, i.e., antioxidants, B vitamins, polyunsaturated fatty acids. Some studies suggest diets such as Mediterranean diet, DASH (Dietary Approaches Stop Hypertension) MIND (Mediterranean-DASH Intervention Neurodegenerative Delay) have beneficial effect risk developing

Language: Английский

Citations

84

Inhibition of inflammation by berberine: Molecular mechanism and network pharmacology analysis DOI
Kaijun Wang, Jie Yin, Jiayi Chen

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 128, P. 155258 - 155258

Published: Jan. 11, 2024

Language: Английский

Citations

64

The multifaceted benefits of walking for healthy aging: from Blue Zones to molecular mechanisms DOI Creative Commons
Zoltán Ungvári, Vince Fazekas‐Pongor, Anna Csiszár

et al.

GeroScience, Journal Year: 2023, Volume and Issue: 45(6), P. 3211 - 3239

Published: July 26, 2023

Abstract Physical activity, including walking, has numerous health benefits in older adults, supported by a plethora of observational and interventional studies. Walking decreases the risk or severity various outcomes such as cardiovascular cerebrovascular diseases, type 2 diabetes mellitus, cognitive impairment dementia, while also improving mental well-being, sleep, longevity. Dose-response relationships for walking duration intensity are established adverse outcomes. Walking’s favorable effects on factors attributed to its impact circulatory, cardiopulmonary, immune function. Meeting current physical activity guidelines briskly 30 min per day 5 days can reduce several age-associated diseases. Additionally, low-intensity exercise, exerts anti-aging helps prevent age-related making it powerful tool promoting healthy aging. This is exemplified lifestyles individuals Blue Zones, regions world with highest concentration centenarians. other activities contribute significantly longevity these regions, being an integral part their daily lives. Thus, incorporating into routines encouraging walking-based interventions be effective strategy aging all populations. The goal this review provide overview vast consistent evidence supporting specific focus discuss outcomes, prevention Furthermore, will delve molecular cellular mechanisms aging, providing insights underlying biological through which beneficial effects.

Language: Английский

Citations

61

Dietary Patterns and Alzheimer’s Disease: An Updated Review Linking Nutrition to Neuroscience DOI Open Access
Inès Ellouze, Julia Sheffler, Ravinder Nagpal

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(14), P. 3204 - 3204

Published: July 19, 2023

Alzheimer's disease (AD) is a growing concern for the aging population worldwide. With no current cure or reliable treatments available AD, prevention an important and area of research. A range lifestyle dietary patterns have been studied to identify most effective preventive changes against AD related dementia (ADRD) pathology. Of these, are Mediterranean, DASH, MIND, ketogenic, modified Mediterranean-ketogenic diets. However, there discrepancies in reported benefits among studies examining these patterns. We herein compile narrative/literature review existing clinical evidence on association with ADRD symptomology contemplate their preventive/ameliorative effects neuropathology various milieus. By large, plant-based found be relatively consistently positively correlated preventing reducing odds ADRD. These impacts stem not only from direct impact specific components within brain but also indirect through decreasing deleterious risk factors, such as diabetes, obesity, cardiovascular diseases. Importantly, other psychosocial factors influence intake, social connection, which may directly diet lifestyle, thereby impacting risk. To this end, prospective research should include holistic approach, including considerations.

Language: Английский

Citations

51

A review on the influence of nutraceuticals and functional foods on health DOI Creative Commons
Arumugam Vignesh,

Thomas Cheeran Amal,

Ariyan Sarvalingam

et al.

Food Chemistry Advances, Journal Year: 2024, Volume and Issue: 5, P. 100749 - 100749

Published: June 10, 2024

In recent years, functional foods have gained attention for their potential health benefits beyond basic nutrition, serving as rich sources of proteins, carbohydrates, vitamins, and dietary fiber. Enriched with bioactive compounds such polyphenols, tannins, flavonoids, alkaloids, these shown promise in inhibiting cell signaling pathways related to proliferation, communication, apoptosis. Key components offer benefits. Omega-3 fatty acids scavenge free radicals, reducing the risk chronic diseases like heart disease cancer. Antioxidants sesame seed oil promote cardiovascular anti-inflammatory effects. Curcumin inhibits cancer by suppressing inflammatory cytokines. Understanding mechanisms action is crucial realizing therapeutic However, identifying suitable substances comprehending role prevention are challenging. As we enter food era, this review aims present current state nutraceuticals, exploring applications human wellness. Recognizing nutrition's individualized nature nutrition a central theme, emphasizing importance tailored recommendations based on diverse responses elements, ensuring that personalized approaches aligned individual goals.

Language: Английский

Citations

34

Exploring the Influence of Gut–Brain Axis Modulation on Cognitive Health: A Comprehensive Review of Prebiotics, Probiotics, and Symbiotics DOI Open Access
Mónika Fekete,

Andrea Lehoczki,

Dávid Major

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(6), P. 789 - 789

Published: March 10, 2024

Recent research exploring the relationship between gut and brain suggests that condition of microbiota can influence cognitive health. A well-balanced may help reduce inflammation, which is linked to neurodegenerative conditions. Prebiotics, probiotics, symbiotics are nutritional supplements functional food components associated with gastrointestinal well-being. The bidirectional communication gut–brain axis essential for maintaining homeostasis, pre-, pro-, potentially affecting various functions such as attention, perception, memory. Numerous studies have consistently shown incorporating into a healthy diet lead improvements in mood. Maintaining support optimal function, crucial disease prevention our fast-paced, Westernized society. Our results indicate benefits older individuals probiotic supplementation but not who good adequate levels physical activity. Additionally, it appears there patients mild impairment Alzheimer’s disease, while mixed seem arise younger healthier individuals. However, important acknowledge individual responses vary, use these dietary should be tailored each individual’s unique health circumstances needs.

Language: Английский

Citations

24

Health Benefits, Food Applications, and Sustainability of Microalgae-Derived N-3 PUFA DOI Creative Commons
Yanjun Liu,

Xiang Ren,

Chao Fan

et al.

Foods, Journal Year: 2022, Volume and Issue: 11(13), P. 1883 - 1883

Published: June 25, 2022

Today's consumers are increasingly aware of the beneficial effects n-3 PUFA in preventing, delaying, and intervening various diseases, such as coronary artery disease, hypertension, diabetes, inflammatory autoimmune disorders, neurodegenerative depression, many other ailments. The role on aging cognitive function is also one hot topics basic research, product development, clinical applications. For decades, PUFA, especially EPA DHA, have been supplied by fish oil seafood. With continuous increase global population, awareness about health benefits socioeconomic improvement worldwide, supply chain facing increasing challenges insufficient production. In this regard, microalgae well considered promising sources to mitigate shortages. use produce PUFA-rich oils has explored for over two decades some species already used commercially particular EPA- and/or DHA-rich oils. addition biomass contains high value biomolecules, which can be food, dietary supplement, pharmaceutical ingredient, feedstock. present review covers EPA, with attention given approaches attempted nutritional interventions using DHA alone or combined nutrients bioactive compounds towards improved conditions people mild impairment Alzheimer's disease. It applications food supplement sectors economic environmental sustainability a platform

Language: Английский

Citations

54