Repurposing non-pharmacological interventions for Alzheimer's disease through link prediction on biomedical literature DOI Creative Commons

Yongkang Xiao,

Yu Hou, Huixue Zhou

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: April 15, 2024

Abstract Non-pharmaceutical interventions (NPI) have great potential to improve cognitive function but limited investigation discover NPI repurposing for Alzheimer's Disease (AD). This is the first study develop an innovative framework extract and represent information from biomedical literature in a knowledge graph (KG), train link prediction models repurpose novel NPIs AD prevention. We constructed comprehensive KG, called ADInt, by extracting literature. used previously-created SuppKG lexicon identify entities. Four KG embedding (i.e., TransE, RotatE, DistMult ComplEX) two convolutional network R-GCN CompGCN) were trained compared learn representation of ADInt. Models evaluated on test sets (time slice clinical trial ground truth) best performing model was predict AD. Discovery patterns applied generate mechanistic pathways high scoring candidates. The ADInt has 162,212 nodes 1,017,284 edges. performed time (MR = 5.2054, Hits@10 0.8496) truth 3.4996, 0.9192) sets. After evaluation domain experts, 10 dietary supplements complementary integrative health proposed score table calculated R-GCN. Among NPIs, we found plausible photodynamic therapy Choerospondias axillaris prevent AD, validated psychotherapy manual techniques using real-world data analysis. shows discovering new prevention understanding their pathways.

Language: Английский

Global, regional, and national burden of Alzheimer's disease and other dementias, 1990–2019 DOI Creative Commons
Xue Li, Xiaojin Feng, Xiaodong Sun

et al.

Frontiers in Aging Neuroscience, Journal Year: 2022, Volume and Issue: 14

Published: Oct. 10, 2022

Background With the increase in aging population worldwide, Alzheimer's disease has become a rapidly increasing public health concern. Monitoring dementia burden will support development strategies by providing scientific data. Methods Based on data obtained from 2019 Global Burden of Disease (GBD) database, numbers and age-standardized rates (ASRs) incidence, prevalence, death, disability-adjusted life-years (DALYs) other dementias 1990 to were analyzed. Calculated estimated annual percentage changes (EAPCs) Joinpoint regression analyses performed evaluate trends during this period. We also evaluated correlations between epidemiology sociodemographic index (SDI), an indicator level social country or region considering education rate, economic situation, total fertility rate. Results From 2019, incidence prevalence increased 147.95 160.84%, respectively. The ASR DALYs both men women consistently over study All ASRs higher than those men, but increases more pronounced men. In addition, positively correlated with SDI. Moreover, proportion patients 70 years old was SDI level. Smoking major risk factor for while obesity women. Conclusion worldwide. This trend serious high-SDI areas, especially among elderly populations who should receive additional attention. Policy-makers take steps reverse situation. Notably, at disease, showed faster increase. give attention population, attach importance interventions targeting factors, formulate action plans address dementia.

Language: Английский

Citations

354
Microbial Nano-Factories: Synthesis and Biomedical Applications DOI Creative Commons

Shubhrima Ghosh,

Razi Ahmad, Md. Zeyaullah

et al.

Frontiers in Chemistry, Journal Year: 2021, Volume and Issue: 9

Published: April 16, 2021

In the recent times, nanomaterials have emerged in field of biology, medicine, electronics, and agriculture due to their immense applications. Owing nanoscale sizes, they present large surface/volume ratio, characteristic structures, similar dimensions biomolecules resulting unique properties for biomedical The chemical physical methods synthesize nanoparticles own limitations which can be overcome using biological synthesis. Moreover, through biogenic synthesis route, usage microorganisms has offered a reliable, sustainable, safe, environmental friendly technique nanosynthesis. Bacterial, algal, fungal, yeast cells are known transport metals from environment convert them elemental nanoparticle forms either accumulated or secreted. Additionally, robust nanocarriers also been developed viruses. order prevent aggregation promote stabilization nanoparticles, capping agents often secreted during biosynthesis. Microbial find applications rapid diagnostics, imaging, biopharmaceuticals, drug delivery systems, antimicrobials, biomaterials tissue regeneration as well biosensors. major challenges therapeutic microbial include biocompatibility, bioavailability, stability, degradation gastro-intestinal tract, immune response. Thus, current review article is focused on microbe-mediated various different strains explored such along with future

Language: Английский

Citations

185
An Activity‐Based Fluorescent Probe for Imaging Fluctuations of Peroxynitrite (ONOO−) in the Alzheimer's Disease Brain DOI

Pengzhan Wang,

Le Yu,

Jiankang Gong

et al.

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 61(36)

Published: July 5, 2022

Abstract Peroxynitrite (ONOO − ) plays a critical role in Alzheimer's disease (AD). To reveal the ONOO influx AD brains, an activatable activity‐based fluorescence probe Rd‐DPA3 was designed by structure‐modulated strategy. Taking advantage of ‐initiated two‐step cascade reactions novel chemical trigger, specifically responds to 0.3 mM other reactive oxygen species (ROS) and varied proteins, gives intensive enhancement ( F / 0 =50). Moreover, with its mitochondria‐targeting ability, can be used efficiently monitor alternations intracellular levels cerebral cells during oxidative stress. Significantly, due NIR emission good blood–brain barrier (BBB) crossing is suitable for vivo imaging illustrating age‐dependent accumulation mice brains.

Language: Английский

Citations

118
Inflammatory Processes in Alzheimer’s Disease—Pathomechanism, Diagnosis and Treatment: A Review DOI Open Access
Bartosz Twarowski, Mariola Herbet

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(7), P. 6518 - 6518

Published: March 30, 2023

Alzheimer’s disease is one of the most commonly diagnosed cases senile dementia in world. It an incurable process, often leading to death. This multifactorial, and factor this inflammation. Numerous mediators secreted by inflammatory cells can cause neuronal degeneration. Neuritis may coexist with other mechanisms disease, contributing progression, also directly underlie AD. Although much has been established about processes pathogenesis AD, many aspects remain unexplained. The work devoted particular pathomechanism inflammation its role diagnosis treatment. An in-depth detailed understanding neuroinflammation help development diagnostic methods for early contribute new therapeutic strategies disease.

Language: Английский

Citations

105
Alzheimer Disease Classification through Transfer Learning Approach DOI Creative Commons

Noman Raza,

Asma Naseer, Maria Tamoor

et al.

Diagnostics, Journal Year: 2023, Volume and Issue: 13(4), P. 801 - 801

Published: Feb. 20, 2023

Alzheimer’s disease (AD) is a slow neurological disorder that destroys the thought process, and consciousness, of human. It directly affects development mental ability neurocognitive functionality. The number patients with increasing day by day, especially in old aged people, who are above 60 years age, and, gradually, it becomes cause their death. In this research, we discuss segmentation classification Magnetic resonance imaging (MRI) disease, through concept transfer learning customizing convolutional neural network (CNN) specifically using images segmented Gray Matter (GM) brain. Instead training computing proposed model accuracy from start, used pre-trained deep as our base model, after that, was applied. tested over different epochs, 10, 25, 50. overall 97.84%.

Language: Английский

Citations

44
Oxidative Stress, Endoplasmic Reticulum Stress and Apoptosis in the Pathology of Alzheimer’s Disease DOI
Bidemi Emmanuel Ekundayo, Tajudeen Olabisi Obafemi, Olusola Bolaji Adewale

et al.

Cell Biochemistry and Biophysics, Journal Year: 2024, Volume and Issue: 82(2), P. 457 - 477

Published: March 12, 2024

Language: Английский

Citations

35
A strategy of monitoring acetylcholinesterase and screening of natural inhibitors from Uncaria for Alzheimer's disease therapy based on near-infrared fluorescence probe DOI

Huanjun Wang,

Yan Zhi,

Wenjie Yang

et al.

Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: 424, P. 136895 - 136895

Published: Nov. 4, 2024

Language: Английский

Citations

32
Characteristics of adverse events and clinical risks of Lecanemab based on FAERS data DOI
Zhaohui Li,

Jun Gu,

Zhiqiang Du

et al.

Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: 374, P. 46 - 54

Published: Jan. 8, 2025

Language: Английский

Citations

2
Crocin: Functional characteristics, extraction, food applications and efficacy against brain related disorders DOI Creative Commons
Anwar Ali, Liang Yu,

Safura Kousar

et al.

Frontiers in Nutrition, Journal Year: 2022, Volume and Issue: 9

Published: Dec. 13, 2022

Crocin is a bioactive compound that naturally occurs in some medicinal plants, especially saffron and gardenia fruit. Different conventional novel methods are used for its extraction. Due to control conditions, recent such as ultrasonic extraction, supercritical fluid enzyme-associated microwave pulsed electric field extraction widely because these give more yield efficiency. incorporated into different food products make functional foods. However, it can also aid the stability of products. ability protect against brain diseases, demand crocin has been rising pharmaceutical industry. It contain antioxidant, anti-inflammatory, anticancer antidepressant qualities. This review aims describe role developing food, bioavailability various brain-related diseases. The results literature strongly support importance diseases use making

Language: Английский

Citations

68
COVID-19 and SARS-CoV-2 Variants: Current Challenges and Health Concern DOI Creative Commons
Md. Zeyaullah, Abdullah M. AlShahrani, Khursheed Muzammil

et al.

Frontiers in Genetics, Journal Year: 2021, Volume and Issue: 12

Published: June 15, 2021

The ongoing coronavirus disease 2019 (COVID-19) outbreak in Wuhan, China, was triggered and unfolded quickly throughout the globe by severe acute respiratory syndrome 2 (SARS-CoV-2). new virus, transmitted primarily through inhalation or contact with infected droplets, seems very contagious pathogenic, an incubation period varying from to 14 days. epidemic is public health problem that challenges present global system. A worldwide social economic stress has been observed. transitional source of origin its transport humans unknown, but speedy human transportation accepted extensively. typical clinical symptoms COVID-19 are almost like colds. With case fatality rates 3 percent, a small number patients may experience serious problems even die. To date, there limited antiviral agents vaccines for treatment COVID-19. occurrence pathogenicity infection outlined comparatively analyzed, given outbreak’s urgency. recent developments diagnostics, treatment, marketed vaccine discussed deal this viral outbreak. Now scientist concerned about appearance several variants over efficacy against these variants. There need consistent monitoring virus epidemiology surveillance variant related severity.

Language: Английский

Citations

64