Clustering and machine learning-based integration identify cancer associated fibroblasts genes’ signature in head and neck squamous cell carcinoma DOI Creative Commons

Qiwei Wang,

Yinan Zhao, Fang Wang

et al.

Frontiers in Genetics, Journal Year: 2023, Volume and Issue: 14

Published: March 30, 2023

Background: A hallmark signature of the tumor microenvironment in head and neck squamous cell carcinoma (HNSCC) is abundantly infiltration cancer-associated fibroblasts (CAFs), which facilitate HNSCC progression. However, some clinical trials showed targeted CAFs ended failure, even accelerated cancer Therefore, comprehensive exploration should solve shortcoming therapies for HNSCC. Methods: In this study, we identified two gene expression patterns performed single‐sample set enrichment analysis (ssGSEA) to quantify construct score system. We used multi-methods reveal potential mechanisms carcinogenesis Finally, integrated 10 machine learning algorithms 107 algorithm combinations most accurate stable risk model. The contained random survival forest (RSF), elastic network (Enet), Lasso, Ridge, stepwise Cox, CoxBoost, partial least squares regression Cox (plsRcox), supervised principal components (SuperPC), generalised boosted modelling (GBM), support vector (survival-SVM). Results: There are clusters present with distinct genes pattern. Compared low CafS group, high group was associated significant immunosuppression, poor prognosis, increased prospect HPV negative. Patients also underwent abundant carcinogenic signaling pathways such as angiogenesis, epithelial mesenchymal transition, coagulation. MDK NAMPT ligand–receptor cellular crosstalk between other may mechanistically cause immune escape. Moreover, prognostic model that developed from could accurately classify patients. Conclusion: revealed would activation coagulation unique possibilities target glycolysis enhance therapy. an unprecedentedly powerful assessing prognosis. Our study contributes understanding complexity patients serves a basis future in-depth exploration.

Language: Английский

Exploring the mystery of tumor metabolism: Warburg effect and mitochondrial metabolism fighting side by side DOI
Yongxin Yu,

Yulang Jiang,

Christian Glandorff

et al.

Cellular Signalling, Journal Year: 2024, Volume and Issue: 120, P. 111239 - 111239

Published: May 28, 2024

Language: Английский

Citations

13
Transcriptional regulation and post-translational modifications in the glycolytic pathway for targeted cancer therapy DOI
Xuan Ni,

Chengpiao Lu,

Guo-qiang Xu

et al.

Acta Pharmacologica Sinica, Journal Year: 2024, Volume and Issue: 45(8), P. 1533 - 1555

Published: April 15, 2024

Language: Английский

Citations

11
The emerging roles of lysine-specific demethylase 4A in cancer: Implications in tumorigenesis and therapeutic opportunities DOI Creative Commons
Guan–Jun Yang, Changyun Li, Tao Fan

et al.

Genes & Diseases, Journal Year: 2023, Volume and Issue: 11(2), P. 645 - 663

Published: March 23, 2023

Language: Английский

Citations

11
The emerging role of deubiquitylating enzyme USP21 as a potential therapeutic target in cancer DOI

Zhen-Yuan Shi,

Changyun Li,

Ru-Yi Chen

et al.

Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 147, P. 107400 - 107400

Published: April 25, 2024

Language: Английский

Citations

4
Ubiquitin-conjugating enzyme E2S decreases the sensitivity of glioblastoma cells to temozolomide by upregulating PGAM1 via the interaction with OTUB2 DOI Creative Commons

Lin Xu,

Baoju Wang,

Zhenbo Gang

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 302, P. 140583 - 140583

Published: Feb. 2, 2025

Language: Английский

Citations

0
TMT-based quantitative proteomics and non-targeted metabolomics reveal the antibacterial mechanism of rhein against Bacillus cereus and its potential application as a food preservative DOI Creative Commons
Yanmei Li, Zixi Chen, Zhenbo Xu

et al.

LWT, Journal Year: 2025, Volume and Issue: 218, P. 117487 - 117487

Published: Feb. 1, 2025

Language: Английский

Citations

0
Fibromyalgia and Inflammation: Unrevealing the Connection DOI Creative Commons
Mario García‐Domínguez

Cells, Journal Year: 2025, Volume and Issue: 14(4), P. 271 - 271

Published: Feb. 13, 2025

Fibromyalgia represents a chronic pain pathology characterized by severe musculoskeletal pain, fatigue, disturbances in sleep, and cognitive issues. Despite its presence, the underlying mechanisms of fibromyalgia remain inadequately understood; however, recent investigations have suggested that inflammation could play fundamental role pathophysiology this condition. Several studies highlight elevated concentrations pro-inflammatory cytokines, dysregulation immune responses, neuroinflammation patients. Furthermore, low-grade has been proposed as potential catalyst for sensitization pathways, which exacerbates symptoms fibromyalgia. Understanding disease might open new avenues therapeutic interventions while providing more profound insight into complex nature debilitating disorder. Although progress made, further research is needed to uncover complexities involved. This review investigates intricate relationship between fibromyalgia, analyzing evidence supports involvement both peripheral central inflammatory processes onset persistence

Language: Английский

Citations

0
2,3,4-Trihydroxybenzophenone-induced cardiac and neurological toxicity: Heart-brain interaction mediated by regulation of pgam1a and pgk1 involved in glycolysis and gluconeogenesis in zebrafish DOI

Lijie Xia,

Rostyslav Stoika, Yuqing Li

et al.

The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 974, P. 179212 - 179212

Published: March 30, 2025

Language: Английский

Citations

0
LncRNA SPINT1-AS1 enhances the Warburg effect and promotes the progression of osteosarcoma via the miR-135b-5p/PGAM1 axis DOI Creative Commons
Jinyou Wang, Ning Zhang, Yan Wang

et al.

Cancer Cell International, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 1, 2025

Osteosarcoma (OS) is a malignant bone tumor that originates from interstitial tissues and affects the health of children adolescents. Long noncoding RNAs (lncRNAs) are an intriguing category widely distributed endogenous involved in OS progression, many which remain functionally uncharacterized. Herein, we observed increased expression lncRNA SPINT1-AS1 cell lines. Further analysis confirmed promotes proliferation metastasis cells. Moreover, miR-135b-5p was identified as downstream target SPINT1-AS1. Through bioinformatics analysis, PGAM1 mRNA validated via RIP luciferase reporter assays. could enhance by promoting aerobic glycolysis, acting ceRNA binding to miR-135b-5p, thereby increasing expression. Taken together, these results indicate functions promoter regulates progression through miR-135b-5p/PGAM1 axis.

Language: Английский

Citations

0
Astragaloside IV as a promising therapeutic agent for liver diseases: current landscape and future perspectives DOI Creative Commons
Chunyan Chen,

Xuexian Bu,

Liping Deng

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 23, 2025

Astragaloside IV (C 41 H 68 O 14 , AS-IV) is a naturally occurring saponin isolated from the root of Astragalus membranaceus widely used traditional Chinese botanical drug in medicine. In recent years, AS-IV has attracted considerable attention for its hepatoprotective properties, which are attributed to low toxicity as well anti-inflammatory, antioxidant and antitumour effects. Numerous preclinical studies have demonstrated potential prevention treatment various liver diseases, including multifactorial injury, metabolic-associated fatty disease, fibrosis cancer. Given promising growing interest research, this review provides comprehensive summary current state research on effects AS-IV, based literature available databases such CNKI, PubMed, ScienceDirect, Google Scholar Web Science. The mechanisms multifaceted, encompassing inhibition inflammatory responses, reduction oxidative stress, improvement insulin leptin resistance, modulation gut microbiota, suppression hepatocellular carcinoma cell proliferation induction tumour apoptosis. Notably, key molecular pathways involved these include Nrf2/HO-1, NF-κB, NLRP3/Caspase-1, JNK/c-Jun/AP-1, PPARα/FSP1 Akt/GSK-3β/β-catenin. Toxicity indicate that high level safety. addition, discusses sources, physicochemical challenges development clinical application providing valuable insights into agent pharmaceutical nutraceutical industries.

Language: Английский

Citations

0