Molecules,
Journal Year:
2023,
Volume and Issue:
28(13), P. 5282 - 5282
Published: July 7, 2023
To
find
potential
α-glucosidase
inhibitors,
indolo[1,2-b]isoquinoline
derivatives
(1–20)
were
screened
for
their
inhibitory
effects.
All
presented
effects
with
IC50
values
of
3.44
±
0.36~41.24
0.26
μM
compared
to
the
positive
control
acarbose
(IC50
value:
640.57
5.13
μM).
In
particular,
compound
11
displayed
strongest
anti-α-glucosidase
activity,
being
~186
times
stronger
than
acarbose.
Kinetic
studies
found
that
compounds
9,
11,
13,
18,
and
19
all
reversible
mix-type
inhibitors.
The
3D
fluorescence
spectra
CD
results
revealed
interaction
between
changed
conformational
changes
α-glucosidase.
Molecular
docking
molecular
dynamics
simulation
indicated
addition,
cell
cytotoxicity
drug-like
properties
also
investigated.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(5), P. 1348 - 1348
Published: April 27, 2023
The
electron-rich
five-membered
aromatic
aza-heterocyclic
imidazole,
which
contains
two
nitrogen
atoms,
is
an
important
functional
fragment
widely
present
in
a
large
number
of
biomolecules
and
medicinal
drugs;
its
unique
structure
beneficial
to
easily
bind
with
various
inorganic
or
organic
ions
molecules
through
noncovalent
interactions
form
variety
supramolecular
complexes
broad
potential,
being
paid
increasing
amount
attention
regarding
more
contributions
imidazole-based
for
possible
application.
This
work
gives
systematical
comprehensive
insights
into
research
on
complexes,
including
anticancer,
antibacterial,
antifungal,
antiparasitic,
antidiabetic,
antihypertensive,
anti-inflammatory
aspects
as
well
ion
receptors,
imaging
agents,
pathologic
probes.
new
trend
the
foreseeable
near
future
toward
chemistry
also
prospected.
It
hoped
that
this
provides
help
rational
design
drug
agents
effective
diagnostic
pathological
Foods,
Journal Year:
2024,
Volume and Issue:
13(11), P. 1681 - 1681
Published: May 27, 2024
The
recent
millennium
has
witnessed
a
notable
shift
in
consumer
focus
towards
natural
products
for
addressing
lifestyle-related
disorders,
driven
by
their
safety
and
cost-effectiveness.
Nutraceuticals
functional
foods
play
an
imperative
role
meeting
nutritional
needs
offering
medicinal
benefits.
With
increased
scientific
knowledge
awareness,
the
significance
of
healthy
lifestyle,
including
diet,
reducing
disease
risk
is
widely
acknowledged,
facilitating
access
to
diverse
safer
diet
longevity.
Plant-based
rich
phytochemicals
are
increasingly
popular
effectively
utilized
management.
Agricultural
waste
from
plant-based
being
recognized
as
valuable
source
nutraceuticals
dietary
interventions.
Citrus
peels,
known
flavonoids,
emerging
promising
health-promoting
ingredient.
Globally,
citrus
production
yields
approximately
15
million
tons
by-products
annually,
highlighting
substantial
potential
utilizing
phyto-therapeutic
nutraceutical
applications.
peels
with
concentrations
ranging
2.5
5.5
g/100
g
dry
weight,
depending
on
variety.
most
abundant
flavonoids
peel
include
hesperidin
naringin,
well
essential
oils
monoterpenes
like
limonene.
extracts
exhibit
high
antioxidant
capacity,
DPPH
radical
scavenging
activities
70
90%,
comparable
synthetic
antioxidants
BHA
BHT.
Additionally,
present
have
been
found
properties,
which
can
help
reduce
oxidative
stress
30%
cardiovascular
25%.
Potent
anti-inflammatory
effects
also
demonstrated,
inflammatory
markers
such
IL-6
TNF-α
up
40%
cell
culture
studies.
These
findings
highlight
diet-based
therapies.
RSC Advances,
Journal Year:
2024,
Volume and Issue:
14(20), P. 14051 - 14067
Published: Jan. 1, 2024
Synthesis
of
mono-
and
bis-thiosemicarbazones
4a–h
5a–h
isatin–triazole
hybrids
3a
3b
in
turn
accessed
via
CuAAC,
their
DFT
studies
potential
as
phosphoinositide
3-kinase
(PI3K)
inhibitors
has
been
evaluated
this
study.
