Biomaterials Advances, Journal Year: 2025, Volume and Issue: 175, P. 214326 - 214326
Published: April 27, 2025
Language: Английский
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: Jan. 29, 2024
Cancer, a disease that modern medicine has not fully understood and conquered, with its high incidence mortality, deprives countless patients of health even life. According to global cancer statistics, there were an estimated 19.3 million new cases nearly 10 deaths in 2020, the age-standardized mortality rates 201.0 100.7 per 100,000, respectively. Although remarkable advancements have been made therapeutic strategies recently, overall prognosis remains optimistic. Consequently, are still many severe challenges be faced difficult problems solved therapy today. Epigallocatechin gallate (EGCG), natural polyphenol extracted from tea leaves, received much attention for antitumor effects. Accumulating investigations confirmed EGCG can inhibit tumorigenesis progression by triggering apoptosis, suppressing proliferation, invasion, migration, altering tumor epigenetic modification, overcoming chemotherapy resistance. Nevertheless, regulatory roles biomolecular mechanisms immune microenvironment, metabolic immunotherapy remain obscure. In this article, we summarized most recent updates about effects on microenvironment (TME), reprogramming, anti-cancer immunotherapy. The results demonstrated promote response cytotoxic lymphocytes dendritic cells (DCs), attenuate immunosuppression myeloid-derived suppressor (MDSCs) T (Tregs), tumor-promoting functions tumor-associated macrophages (TAMs), neutrophils (TANs), various stromal including cancer-associated fibroblasts (CAFs), endothelial (ECs), stellate cells, mesenchymal stem/stromal (MSCs). Additionally, suppress multiple reprogramming pathways, glucose uptake, aerobic glycolysis, glutamine metabolism, fatty acid anabolism, nucleotide synthesis. Finally, EGCG, as immunomodulator checkpoint blockade, enhance immunotherapeutic efficacy may promising candidate conclusion, plays versatile TME which provides novel insights combined
Language: Английский
Citations
16
Microchemical Journal, Journal Year: 2025, Volume and Issue: 210, P. 112917 - 112917
Published: Jan. 30, 2025
Language: Английский
Citations
2
Cells, Journal Year: 2023, Volume and Issue: 12(7), P. 986 - 986
Published: March 23, 2023
Continuous monitoring of the population’s health is main method learning about disease prevalence. National and international data draw attention to persistently high rates cancer incidence. This necessitates intensification efforts aimed at developing new, more effective chemotherapeutic chemopreventive drugs. Plants represent an invaluable source natural substances with versatile medicinal properties. Multidirectional activities exhibited by their ability modulate key signaling pathways, mainly related cell death, make these important research direction. review summarizes information regarding plant-derived drugs, including mechanisms action, a special focus on selected anti-cancer drugs (paclitaxel, irinotecan) approved in clinical practice. It also presents promising plant-based drug candidates currently being tested preclinical trials (betulinic acid, resveratrol, roburic acid).
Language: Английский
Citations
35
Nutrients, Journal Year: 2023, Volume and Issue: 15(15), P. 3443 - 3443
Published: Aug. 3, 2023
The exploration of non-toxic and cost-effective dietary components, such as epigallocatechin 3-gallate myricetin, for health improvement disease treatment has recently attracted substantial research attention. recent COVID-19 pandemic provided a unique opportunity the investigation identification components capable treating viral infections, well gathering evidence needed to address major challenges presented by public emergencies. Dietary hold great potential starting point further drug development prevention SARS-CoV-2 infection owing their good safety, broad-spectrum antiviral activities, multi-organ protective capacity. Here, we review current knowledge characteristics-chemical composition, bioactive properties, putative mechanisms action-of natural flavonoids with targeting its variants. Notably, present promising strategies (combination therapy, lead optimization, delivery) overcome inherent deficiencies flavonoids, limited bioavailability poor stability.
Language: Английский
Citations
25
Drug and Chemical Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 43
Published: Jan. 23, 2025
Cyclophosphamide is a key component of numerous chemotherapeutic protocols, demonstrating broad-spectrum efficacy against various malignancies and non-cancerous conditions. This review examines CPM's metabolic pathways, therapeutic applications, its resulting organ-specific toxicities. Despite clinical benefits in treating nephrotic syndrome, encephalomyelitis, breast cancer, ovarian other diseases, CPM associated with significant adverse effects on the kidneys, liver, heart, lungs, intestines. The discussion delves into molecular mechanisms underlying these toxicities, highlighting dysregulation signaling including Nrf2, NF-κB, MAPK/ERK, AKT. In addressing challenges, recent studies have identified herbal drugs phytochemicals capable mitigating CPM-induced toxicity. Notable compounds such as cinnamaldehyde, baicalin, quercetin, curcumin demonstrated protective effects. Integrating formulations therapy proposed to enhance patient safety treatment efficacy. underscores influence apoptosis inflammation which lead alterations biomarkers. Phytochemicals may exert by restoring disrupted pathways normalizing altered compilation presented this serves valuable resource for researchers exploring products potential A gap current literature lack trials evaluating that mitigate toxicity vivo. Rigorous are necessary establish cancer treatment. Such research will clarify role natural remedies complementing conventional therapies, ultimately improving outcomes.
Language: Английский
Citations
1
MedComm – Oncology, Journal Year: 2024, Volume and Issue: 3(1)
Published: March 1, 2024
Abstract Synthetic lethality (SL), a genetic concept, has revolutionized the development of antitumor therapies by providing avenues to target previously “undruggable” targets with enhanced specificity for tumor cells over normal tissue. The principles SL have expanded beyond definitions encompass biological functions, including genome stability, cell cycle regulation, death mechanisms, cellular metabolism, cell–cell interactions, and microenvironment (TME). Tumor inactivated survival pathways are sensitive therapeutic inhibition compensatory while remain unaffected. Exploiting based on functional contexts potential significantly improve cancer patient reducing resistance targeted enhancing efficacy when combined other treatment modalities. This review explores underlying mechanisms synthetic interactions (SLI) characterized functions in individual TME. We also provide comprehensive summary strategies leveraging dynamic nature SLI overcome resistance. Additionally, we discuss various approaches models screening designing potent agents tailored specific needs patients, as well combining drugs treatment. offers valuable insights into harnessing promising avenue precision therapy.
Language: Английский
Citations
7
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 178, P. 117217 - 117217
Published: July 29, 2024
Doxorubicin (DOX), a commonly used chemotherapy drug, is hindered due to its tendency induce cardiotoxicity (DIC). Ferroptosis, novel mode of programmed cell death, has received substantial attention for involvement in DIC. Recently, natural product-derived ferroptosis regulator emerged as potential strategy treating In this review, comprehensive search was conducted across PubMed, Web Science, Google Scholar, and ScienceDirect databases gather relevant articles on the use products DIC relation ferroptosis. The available papers were carefully reviewed summarize therapeutic effects underlying mechanisms modulating treatment. It found that plays an important role pathogenesis, with dysregulated expression ferroptosis-related proteins strongly implicated condition. Natural products, such flavonoids, polyphenols, terpenoids, quinones can act GPX4 activators, Nrf2 agonists, lipid peroxidation inhibitors, thereby enhancing viability, attenuating myocardial fibrosis, improving cardiac function, suppressing both vitro vivo models This review demonstrates strong correlation between DOX-induced key proteins, GPX4, Keap1, Nrf2, AMPK, HMOX1. are likely exert against by activity these proteins.
Language: Английский
Citations
7
Phytomedicine, Journal Year: 2024, Volume and Issue: 130, P. 155643 - 155643
Published: April 14, 2024
Language: Английский
Citations
6
British Journal of Pharmacology, Journal Year: 2023, Volume and Issue: unknown
Published: Aug. 24, 2023
Abstract Tannins are a heterogenous class of polyphenolic natural products with promising cancer chemopreventive and therapeutic potential. Studies undertaken over the last 30 years have demonstrated their capacity to target many cellular pathways molecules important in development cancer. Recently, new mechanisms that might be anti‐carcinogenic activity, such as inhibition epithelial‐to‐mesenchymal transition, reduction stem cell creation, modulation cells metabolism been described. Along underlying anti‐cancer activity tannins, this review focuses on possible application chemosensitizers adjuvant therapy countering multidrug resistance. Furthermore, characteristic physicochemical properties some particularly tannic acid, useful formation nanovehicles for anticancer drugs or isolation circulating cells. These potential applications tannins deserve further studies. Well‐designed clinical trials, which scarce, needed assess effects themselves adjuvants treatment.
Language: Английский
Citations
15
Molecular Biomedicine, Journal Year: 2024, Volume and Issue: 5(1)
Published: Dec. 27, 2024
Abstract Green tea has garnered increasing attention across age groups due to its numerous health benefits, largely attributed Epigallocatechin 3-gallate (EGCG), key polyphenol. EGCG exhibits a wide spectrum of biological activities, including antioxidant, anti-inflammatory, antibacterial, anticancer, and neuroprotective properties, as well benefits for cardiovascular oral health. This review provides comprehensive overview recent findings on the therapeutic potential in various human diseases. Neuroprotective effects include safeguarding neurons from damage enhancing cognitive function, primarily through antioxidant capacity reduce reactive oxygen species (ROS) generated during physiological stress. Additionally, modulates signaling pathways such JAK/STAT, Delta-Notch, TNF, all which play critical roles neuronal survival, growth, function. Furthermore, is involved regulating apoptosis cell cycle progression, making it promising candidate treatment metabolic diseases, cancer diabetes. Despite potential, further clinical trials are essential validate efficacy safety optimize delivery target tissues. While many reviews have addressed anticancer properties EGCG, this focuses molecular mechanisms by used specific particularly cancer, neurodegenerative It serves valuable resource researchers, clinicians, healthcare professionals, revealing managing disorders, diseases highlighting broader values.
Language: Английский
Citations
5