Dietary factors and their influence on immunotherapy strategies in oncology: a comprehensive review

Cell Death and Disease, Journal Year: 2024, Volume and Issue: 15(4)

Published: April 9, 2024

Abstract Immunotherapy is emerging as a promising avenue in oncology, gaining increasing importance and offering substantial advantages when compared to chemotherapy or radiotherapy. However, the context of immunotherapy, there potential for immune system either support hinder administered treatment. This review encompasses recent pivotal studies that assess influence dietary elements, including vitamins, fatty acids, nutrients, small molecules, patterns, caloric restriction, on ability modulate responses. Furthermore, article underscores how these factors have modify enhance effectiveness anticancer immunotherapy. It emphasizes necessity additional research comprehend underlying mechanisms optimizing efficacy therapy defining strategies may reduce cancer-related morbidity mortality. Persistent investigation this field holds significant promise improving cancer treatment outcomes maximizing benefits

Language: Английский

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Nanomaterials in cancer immunotherapy: targeting cancer-associated fibroblasts

Cancer Nanotechnology, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 17, 2025

Emphasizing the significance of cancer-associated fibroblasts (CAFs), non-malignant yet pivotal players within tumor microenvironment (TME), this review illuminates role inflammatory subtype (iCAF) as catalysts in cancer proliferation, metastasis, and therapeutic resistance. Given their paramount importance, targeting CAFs emerges a robust strategy evolving landscape immunotherapy. Nanomaterials, distinguished by unique features malleability, hold considerable promise biomedicine, especially precision-oriented domain therapy. Their aptitude for modulating immune responses, amplifying drug efficacy through precise delivery, discerningly focusing on cells TME situates nanomaterials formidable tools to transcend boundaries set conventional treatments. This scrutinizes convoluted interplay among CAFs, cells, TME. It further showcases widely utilized management. We underscore potential nanoscale delivery systems directed at underscoring transformative power revolutionizing therapies, enhancing precision, culminating improved patient outcomes.

Language: Английский

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EGCG suppresses PD-1 expression of T cells via inhibiting NF-κB phosphorylation and nuclear translocation

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 133, P. 112069 - 112069

Published: April 20, 2024

Language: Английский

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Unlocking the adenosine receptor mechanism of the tumour immune microenvironment

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: June 27, 2024

The suppressive tumour microenvironment significantly hinders the efficacy of immunotherapy in treating solid tumors. In this context, stromal cells, such as tumour-associated fibroblasts, undergo changes that include an increase number and function immunosuppressive cells. Adenosine, a factor promotes growth, is produced from ATP breakdown markedly elevated microenvironment. It acts through specific binding to adenosine receptors, with A2A A2B receptor being primary drivers immunosuppression. This paper presents roles various receptors different microenvironments. review focus on cells non-cellular components Additionally, we summarize discuss recent advances potential trends using antagonists combined immunotherapy.

Language: Английский

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Integrative pan-cancer analysis and experiment validation identified GLS as a biomarker in tumor progression, prognosis, immune microenvironment, and immunotherapy

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 2, 2025

Glutaminase (GLS), a crucial gene regulating glutaminolysis, has received much attention as it was found to regulate tumor metabolism and copper-induced cell death. However, its biological roles mechanisms in human cancers remain obscure. Consequently, the integrated pan-cancer analyses experiments were conducted elucidate oncological functions. We GLS differentially expressed upregulated predicted poor survival, clinicopathological progression, heterogeneity. Single-cell analysis closely related various functions pathways. Spatial transcriptomic expression mainly derived from cells, which implies cells may have stronger ability utilize glutamine than antitumor immune microenvironment (TME). Meanwhile, we noticed strongly infiltration of stromal immunomodulatory genes, activity some conventional agents, therapeutic response immunotherapy. Moreover, enrichment suggested metabolic reprogramming, innate adaptive immunity suppression, extracellular matrix remodeling. Finally, observed highly our gastric cancer (GC) cohort. As an independent risk factor for GC prognosis, high-GLS pathological progression. Inhibiting effectively prevented proliferation, migration, invasion triggered apoptosis. In conclusion, is underlying biomarker TME, drug sensitivity, immunotherapy response. Targeting can facilitate implementation individualized combined treatment strategies.

Language: Английский

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Natural products as part of triple negative breast cancer

Pharmacia, Journal Year: 2025, Volume and Issue: 72, P. 1 - 11

Published: Jan. 30, 2025

Triple negative breast cancer (TNBC) continues to be the subtype with highest recurrence and mortality rates. Treatment of TNBC can challenging because disease has different molecular subtypes. Various treatment options are available, such as chemotherapy, immunotherapy, radiation therapy, surgery. Chemotherapy is most common these options. The serious side effects chemotherapy significantly limit its use. Long-term toxicity affect majority survivors, reducing their quality life. Immunotherapy causes a wide variety toxic called immune-related adverse events (IRAEs). This necessitates search for alternative methods triple cancer. More more research in this field focused on single or combination therapy based compounds obtained from natural sources. Natural products curcumin, resveratrol, epigallocatechin-3-gallate, mechanisms action antineoplastic properties, subject numerous studies.

Language: Английский

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Green Tea Catechins: A Promising Anticancer Approach for Leukaemia

Planta Medica, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Abstract Green tea catechins are bioactive polyphenolic compounds that possess a number of biological activities and potential health benefits. This review will focus on discussing the effects green catechins, with particular emphasis clinical studies evaluate their anticancer potential. Epigallocatechin gallate (EGCG), either as stand-alone treatment or in conjunction conventional therapies, represents promising alternative strategy for management leukaemia. was based search scientific sources indexed databases PubMed Scopus using following keywords: ‘Camellia sinensis’, ‘tea catechins’, ‘anticancer’, ‘antioxidant’, ‘hematological cancer’, ‘leukaemia’ combination. A deeper comprehension multifaceted mechanisms findings research could facilitate development novel strategies integration into practice, thus enhancing outcomes patients

Language: Английский

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The pathogenesis and therapeutic implications of metabolic reprogramming in renal cell carcinoma

Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)

Published: April 19, 2025

Abstract Renal cell carcinoma (RCC), a therapeutically recalcitrant genitourinary malignancy, exemplifies the profound interplay between oncogenic signaling and metabolic adaptation. Emerging evidence positions reprogramming as central axis of RCC pathogenesis, characterized by dynamic shifts in nutrient utilization that transcend canonical Warburg physiology to encompass lipid anabolism, glutamine auxotrophy, microenvironment-driven plasticity. This orchestrated rewiring cellular energetics sustains tumor proliferation under hypoxia while fostering immunosuppression through metabolite-mediated T exhaustion myeloid-derived suppressor activation. Crucially, exhibits heterogeneity across histological subtypes intratumoral regions—a feature increasingly recognized determinant therapeutic resistance. Our review systematically deciphers molecular architecture metabolism, elucidating how VHL/HIF mutations, mTOR pathway dysregulation, epigenetic modifiers converge reshape glucose flux, droplet biogenesis, amino acid catabolism. We present novel insights into spatial zonation within tumors, where pseudohypoxic niches engage lactate shuttling cholesterol efflux adjacent vasculature, creating pro-angiogenic immunosuppressive microdomains. Therapeutically, we evaluate first-in-class inhibitors targeting rate-limiting enzymes de novo lipogenesis proposing biomarker-driven strategies overcome compensatory highlight synergy glutaminase PD-1 blockade reinvigorating CD8 + function, role lipid-loaded cancer-associated fibroblasts shielding tumors from ferroptosis. Finally, outline translational roadmap integrating multi-omics profiling, functional metabolomics, biology match vulnerabilities with precision therapies.

Language: Английский

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Recent advances in understanding the immune microenvironment in ovarian cancer

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: June 5, 2024

The occurrence of ovarian cancer (OC) is a major factor in women’s mortality rates. Despite progress medical treatments, like new drugs targeting homologous recombination deficiency, survival rates for OC patients are still not ideal. tumor microenvironment (TME) includes cells, fibroblasts linked to (CAFs), immune-inflammatory and the substances these cells secrete, along with non-cellular components extracellular matrix (ECM). First, TME mainly plays role inhibiting growth protecting normal cell survival. As tumors progress, gradually becomes place promote progression. Immune have attracted much attention as targets immunotherapy. checkpoint inhibitor (ICI) therapy has potential regulate TME, suppressing factors that facilitate advancement, reactivating immune managing growth, extending advanced cancer. This review presents an outline current studies on distinct cellular elements within detailing their main functions possible signaling pathways. Additionally, we examine immunotherapy rechallenge OC, specific emphasis biological reasons behind resistance ICIs.

Language: Английский

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Advancements in Autophagy Modulation for the Management of Oral Disease: A Focus on Drug Targets and Therapeutics

Biomedicines, Journal Year: 2024, Volume and Issue: 12(11), P. 2645 - 2645

Published: Nov. 19, 2024

Autophagy is an intrinsic breakdown system that recycles organelles and macromolecules, which influences metabolic pathways, differentiation, thereby cell survival. Oral health essential component of integrated well-being, it critical for developing therapeutic interventions to understand the molecular mechanisms underlying maintenance oral homeostasis. However, because complex dynamic relationship between autophagy health, associated treatment modalities have not yet been well elucidated. Determining how affects at level may enhance understanding prevention targeted diseases. At level, hard soft tissues develop interactions epithelial mesenchymal cells. Aging contributes progression various disorders including periodontitis, cancer, periapical lesions during aging. levels decrease with age, thus indicating a possible association In this review, we critically review aspects their significance in context diseases lesions, periodontal conditions, candidiasis. A better its can guide us new preventative strategies management

Language: Английский

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