Chiral
vanadium
complexes,
featuring
a
Schiff
base
ligand
and
metal
center,
have
garnered
attention
as
environmentally
benign
catalysts
facilitating
the
generation
of
axially
chiral
molecules.
This
chapter
explores
recent
advancements
in
vanadium-catalyzed
oxidative
coupling
arenols
their
applications
synthesizing
polycyclic
heteroaromatics
(PHAs).
Through
detailed
investigations,
highlights
significant
role
complexes
enabling
chemo-,
regio-,
and/or
enantioselective
CC
bondforming
reactions
to
construct
atropisomers.
Beyond
catalysis,
it
also
delves
into
these
atroposelective
synthesis
heterocyclic
nanographenes,
including
helicenes
dehydrohelicenes,
renowned
for
favorable
optical
properties.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
26(1), P. 288 - 288
Published: Dec. 31, 2024
Alkaloids
are
predominantly
nitrogen-containing
heterocyclic
compounds
that
usually
isolated
from
plants,
and
sometimes
insects
or
animals.
one
of
the
most
important
types
natural
products
due
to
their
diverse
biological
activities
potential
applications
in
modern
medicine.
Cyclic
imines
were
chosen
as
starting
for
synthesis
alkaloids
high
synthetic
potential.
Thus,
this
review
summarizes
achievements
various
cyclic
imines,
paying
special
attention
stereoselective
methods
used
preparation.
Information
on
activity
some
alkaloids,
application
occurrence
objects
is
presented.
Synthesis
classified
based
type
alkaloid
obtained.
Polymers,
Journal Year:
2024,
Volume and Issue:
16(6), P. 862 - 862
Published: March 21, 2024
In
this
paper,
for
the
first
time,
photopolymers
were
synthesized
from
glycerol
acrylates
with
different
numbers
of
functional
groups,
2-hydroxy-3-phenoxypropyl
acrylate,
dimethacrylate
or
trimethacrylate,
without
and
addition
vanillin
styrene.
The
photocuring
kinetics
monitored
by
real-time
photorheometry.
mechanical,
rheological,
thermal,
antimicrobial
shape-memory
properties
investigated.
All
polymers
demonstrated
antibacterial
activity
against
Escherichia
coli
Staphylococcus
aureus,
as
well
antifungal
Aspergillus
flavus
niger.
2-Hydroxy-3-phenoxypropyl
acrylate-based
showed
thermoresponsive
behavior.
They
able
to
maintain
their
temporary
shape
below
glass
transition
temperature
return
permanent
above
temperature.
Synthesized
have
potential
be
used
sustainable
in
a
wide
range
applications
such
biomedicine,
photonics,
electronics,
robotics,
etc.
Plants,
Journal Year:
2024,
Volume and Issue:
13(10), P. 1412 - 1412
Published: May 18, 2024
is
an
opportunistic
pathogen
that
especially
dominant
in
people
with
cystic
fibrosis;
the
drug
resistance
expressed
by
this
and
its
capacity
for
adaptation
poses
a
significant
challenge
to
treatment
control,
thereby
increasing
morbidity
mortality
rates
globally.
In
sense,
search
new
alternatives
imminent
today,
products
of
plant
origin
being
excellent
alternative
use.
The
objective
research
was
evaluate
antibacterial
antibiofilm
potential
explore
possible
effect
ethanolic
extracts
from
wood
bark
Nanotechnology,
Journal Year:
2024,
Volume and Issue:
35(36), P. 365101 - 365101
Published: June 4, 2024
Abstract
Give
the
emergence
of
drug
resistance
in
bacteria
resulting
from
antibiotic
misuse,
there
is
an
urgent
need
for
research
and
application
novel
antibacterial
approaches.
In
recent
years,
nanoparticles
(NPs)
have
garnered
significant
attention
due
to
their
potential
disrupt
cellular
structure
through
loading
drugs
special
mechanisms,
thus
rendering
them
inactive.
this
study,
surface
hollow
polydopamine
(HPDA)
NPs
was
utilized
growth
Prussian
blue
(PB),
formation
HPDA-PB
NPs.
Incorporation
Co
element
during
preparation
process
led
partial
doping
PB
with
2+
ions.
The
performance
test
results
demonstrated
that
exhibited
superior
photothermal
conversion
efficiency
peroxidase-like
activity
compared
ability
catalyze
hydroxyl
radicals
H
2
O
a
weakly
acidic
environment.
Due
tiny
particles
on
presence
doping,
they
strong
broad-spectrum
properties.
Both
vitro
vivo
evaluations
confirm
efficacy
against
various
bacterial
strains,
particularly
Staphylococcus
aureus
,
promote
wound
healing,
making
promising
candidate
advanced
care
antimicrobial
applications.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(25), P. 5243 - 5247
Published: June 13, 2024
The
first
total
syntheses
of
glycoborinine,
clausenawalline
A,
and
E
were
achieved.
key
step
employed
a
vanadium-catalyzed
oxidative
coupling
two
hydroxycarbazole
monomers.
High-throughput
experimentation
was
used
to
identify
conditions
favoring
selective
heterocoupling
these
monomers
that
possess
similar
redox
potentials.
A
combination
vanadium
catalyst
4-acetamido-TEMPO
gives
rise
greatly
enhanced
cross
selectivity
relative
the
alone.
Conditions
selectively
form
homodimer
or
heterodimer
as
major
product
found.
ChemistrySelect,
Journal Year:
2024,
Volume and Issue:
9(28)
Published: July 21, 2024
Abstract
G‐quadruplex
DNA
(GQ‐DNA)
represents
one
of
the
most
significant
non‐canonical
nucleic
acid
configurations.
GQ‐DNA
producing
sequences
are
found
in
different
important
genomic
areas,
including
promoter
islands
numerous
oncogenes
and
human
telomere
regions.
Therefore,
is
a
key
target
for
anticancer
medicines.
has
highly
variable
structure,
it
critical
to
develop
ligand
molecules
that
selectively
certain
quadruplex
sequences.
Natural
products
such
as
pyridocarbazole
alkaloids
have
grown
interest
healthcare
medicinal
values
they
considered
valuable
source
innovative
medicines
among
chemical
compounds.
In
this
investigation,
we
synthesised
characterized
pyrido[2,3‐c]carbazole
derivative
(PCAD)
through
NMR
IR
spectra
explore
interactions
between
PCAD
Pu24T
GQ
(promoter
region),
h‐TELO
(telomere
region)
duplex
by
employing
several
multi‐spectroscopic
analytical
techniques.
We
preferentially
interacts
with
compared
other
These
findings
highlights
an
appealing
option
targeting
region
consequently
acting
anti‐cancer
drug.
This
study
also
potential
developing
drugs
understand
molecular
aspects
recognition
signaling,
paving
way
future
research
on
biology.
Pseudomonas
aeruginosa
is
an
opportunistic
pathogen,
especially
dominant
in
people
with
cystic
fibrosis;
the
drug
resistance
expressed
by
this
pathogen
and
its
capacity
for
adaptation
generate
a
great
challenge
treatment
control,
increasing
morbidity
mortality
rates
globally.
In
sense,
search
new
alternatives
imminent
today,
products
of
plant
origin
being
excellent
alternative
to
be
used.
The
objective
research
was
evaluate
antibacterial
antibiofilm
potential
explore
possible
effect
ethanolic
extracts
wood
bark
Duguetia
vallicola
on
cell
membrane.
Microdilution
assays
showed
inhibition
bacterial
growth
more
than
50%,
lowest
concentration
evaluated
(62.5μg/mL)
both
extracts.
Furthermore,
we
report
ability
inhibit
mature
biofilms,
percentages
between
48.4%
93.7%.
Intracellular
material
leakage
experiments
(260/280
nm),
extracellular
pH
measurement,
fluorescence
microscopy
acridine
orange
(AO)
ethidium
bromide
(EB)
membrane
damage.
This
indicates
that
anti-bacterial
action
D.
associated
damage
integrity
consequent
death
these
pathogens.
These
results
serve
as
reference
future
studies
establishing
mechanisms
Journal of Applied Pharmaceutical Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
The
new
name
of
Murraya
koenigii
(L.)
Spreng.
is
Bergera
L.,
the
Indian
curry
leaf
tree.
Constituents
carbazole
alkaloids
from
different
plant
parts
B.
are
compiled.
Based
on
number
reports,
mahanimbine
(MNB)
and
koenimbine
two
most
dominant
koenigii.
Carbazole
selected
for
review
mahanine
(MN),
isomahanine
(IMN),
MNB,
girinimbine
(GNB)
which
pyranocarbazoles
as
they
possess
pyranocarbazole
skeleton.
MN,
IMN,
MNB
have
23
carbons
four
methyl
groups,
while
GNB
has
18
three
groups.
anti-cancer
properties
extracts
tabulated
with
information
cancer
types,
cell
lines,
effects,
mechanisms.
Other
pharmacological
briefly
mentioned.
Findings
that
will
generate
interest
further
research
included
concluding
remarks.
Eight
areas
future
were
suggested.
