A simple, highly selective ferrocene-based chalcone fluorescent probe for the detection of CrO42− and Cr2O72− ions DOI
Yuting Liu, Zixu Zhang,

Dawei Yin

et al.

Journal of Organometallic Chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 123489 - 123489

Published: Dec. 1, 2024

Language: Английский

The Significance of Mono‐ and Dual‐Effective Agents in the Development of New Antifungal Strategies DOI Creative Commons

Cengiz Zobi,

Öztekin Algül

Chemical Biology & Drug Design, Journal Year: 2025, Volume and Issue: 105(1)

Published: Jan. 1, 2025

ABSTRACT Invasive fungal infections (IFIs) pose significant challenges in clinical settings, particularly due to their high morbidity and mortality rates. The rising incidence of these infections, coupled with increasing antifungal resistance, underscores the urgent need for novel therapeutic strategies. Current drugs target cell membrane, wall, or intracellular components, but resistance mechanisms such as altered drug‐target interactions, enhanced efflux, adaptive cellular responses have diminished efficacy. Recent research has highlighted potential dual inhibitors that simultaneously multiple pathways enzymes involved growth survival. Combining pharmacophores, lanosterol 14α‐demethylase (CYP51), heat shock protein 90 (HSP90), histone deacetylase (HDAC), squalene epoxidase (SE) inhibitors, led development compounds activity reduced resistance. This dual‐target approach, along chemical scaffolds, not only represents a promising strategy combating is also being utilized anticancer agents. review explores new agents employ mono‐, dual‐, multi‐target strategies combat IFIs. We discuss emerging targets, mechanisms, innovative approaches offer hope managing challenging infections.

Language: Английский

Citations

2
N-Heterocyclic functionalized chalcone derivatives as anti-inflammatory agents for atopic dermatitis treatment by inhibiting JAK1/STAT3 signaling pathway DOI

Zhengxiao Huang,

Xinjia Zhang, Jing Li

et al.

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 108200 - 108200

Published: Jan. 1, 2025

Language: Английский

Citations

0
New azole derivatives linked to indole/indoline moieties combined with FLC against drug-resistant Candida albicans DOI

Yunhong Shen,

Min Pan,

Hui Gao

et al.

RSC Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 15(4), P. 1236 - 1246

Published: Jan. 1, 2024

A series of novel azole derivatives linked to indole/indoline moieties were prepared. If combined with FLC, they had high activity against drug-resistant Candida albicans in vitro .

Language: Английский

Citations

2
Synergistic activity between conventional antifungals and chalcone-derived compound against dermatophyte fungi and Candida spp. DOI
Taiza Maschio-Lima, Thiago Henrique Lemes, Mariela Domiciano Ribeiro

et al.

International Microbiology, Journal Year: 2024, Volume and Issue: unknown

Published: May 31, 2024

Language: Английский

Citations

1
Synthesis and antifungal evaluation of new azole derivatives containing 1,2,3-triazole DOI

Zhengxiao Huang,

Hongjie Chen,

Xiao Zhang

et al.

RSC Medicinal Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 29, 2024

Invasive fungal infections caused by

Language: Английский

Citations

1
A simple, highly selective ferrocene-based chalcone fluorescent probe for the detection of CrO42− and Cr2O72− ions DOI
Yuting Liu, Zixu Zhang,

Dawei Yin

et al.

Journal of Organometallic Chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 123489 - 123489

Published: Dec. 1, 2024

Language: Английский

Citations

0