Curcumin in Cancer and Inflammation: An In-Depth Exploration of Molecular Interactions, Therapeutic Potentials, and the Role in Disease Management

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(5), P. 2911 - 2911

Published: March 2, 2024

This paper delves into the diverse and significant roles of curcumin, a polyphenolic compound from Curcuma longa plant, in context cancer inflammatory diseases. Distinguished by its unique molecular structure, curcumin exhibits potent biological activities including anti-inflammatory, antioxidant, potential anticancer effects. The research comprehensively investigates curcumin’s interactions with key proteins involved progression response, primarily through docking studies. In cancer, effectiveness is determined examining interaction pivotal like CDK2, CK2α, GSK3β, DYRK2, EGFR, among others. These suggest role impeding cell proliferation survival. Additionally, highlights impact on inflammation influence such as COX-2, CRP, PDE4, MD-2, which are central to pathway. vitro clinical studies extensively reviewed, shedding light binding mechanisms, pharmacological impacts, therapeutic application various cancers conditions. understanding functionality agent. Conclusively, this review emphasizes promise treating wide range health issues, attributed complex chemistry broad properties. points towards growing importance multi-faceted natural medical scientific community.

Language: Английский

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Synthesis, design, and cholinesterase inhibitory activity of novel 1,2,4-triazole Schiff bases: A combined experimental and computational approach

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141350 - 141350

Published: Feb. 1, 2025

Language: Английский

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Self-assembly of amphiphilic helical-coiled peptide nanofibers and inhibition of fibril formation with curcumin

Bioorganic & Medicinal Chemistry Letters, Journal Year: 2024, Volume and Issue: 102, P. 129682 - 129682

Published: March 1, 2024

Amphiphilic peptide sequences are conducive to secondary structures that self-assemble into higher-ordered nanostructures. A select set of amphiphilic polycationic peptides displayed stable helical-coiled self-assembled nanofibers. The progression fibril formation revealed short protofibrils extended thin filaments and an entangled network nanofibers over (5 days) incubation period. Ligand binding with 8-anilinonaphthalene-1-sulfonic acid (ANS) Congo Red (CR) confirmed the structure assembly nanofibers, whereas curcumin treatment led inhibition formation. Considering vast repertoire fibrous biomaterials or protein (mis)folding contingent on formation, this work relates molecular interplay in between sequence composition, structural folding ligand events impacting self-assembly

Language: Английский

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Evolution of lipid nanoparticles as charioteers of Alzheimer's disease therapeutics

Applied Materials Today, Journal Year: 2024, Volume and Issue: 41, P. 102442 - 102442

Published: Sept. 23, 2024

Language: Английский

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Novel donepezil-tacrine hybrid (TAHB3) induces neurodifferentiation, neuroprotective effects, and activates the PI3K/AKT pathway on PC12 cells

Journal of Alzheimer s Disease Reports, Journal Year: 2025, Volume and Issue: 9

Published: Jan. 1, 2025

Alzheimer's disease (AD) is a neurodegenerative characterized by the impairment of cognitive functions and neuronal loss. AD has no cure; current treatments like acetylcholinesterase inhibitors (AChEI) alleviate symptoms but do not halt progression. We aimed to evaluate effects mechanisms two novel AChEI hybrid compounds (TAHB3 TA8Amino), regarding cytotoxicity, neuroprotection neurodifferentiation in PC12 cells. The TAHB3 TA8Amino on were analyzed cells which treated with for seven days, following morphological, quantitative analyses calculate differentiation percentages, neurite length, protein expression. Regarding cytotoxicity assays, differentiated into mature neurons, then or TA8Amino, posttreatment H2O2 (an inducer oxidative damage); performed using XTT assay flow cytometry. compound induced cells, did cause same effect. Both show cytotoxic change cell cycle progression, nor induce death. Only showed neuroprotective potential against induced-oxidative damage, increased levels p-AKT, suggesting its action through activation PI3K/AKT pathway. Our results that can neurodifferentiation, besides activity, indicating as candidates be explored establishment therapeutic strategies patients AD.

Language: Английский

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Effect of spacer of cationic gemini surfactant on solubility and stability of curcumin

Journal of Molecular Liquids, Journal Year: 2025, Volume and Issue: 426, P. 127345 - 127345

Published: March 9, 2025

Language: Английский

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Natural Products Targeting Tau Protein Phosphorylation: A Promising Therapeutic Avenue for Alzheimerʼs Disease

Planta Medica, Journal Year: 2025, Volume and Issue: unknown

Published: March 14, 2025

Abstract Alzheimerʼs disease is a progressive neurodegenerative disorder characterized by tau protein hyperphosphorylation and neurofibrillary tangle formation, which are central to its pathogenesis. This review focuses on the therapeutic potential of natural products in targeting phosphorylation, key factor progression. It comprehensively summarizes current research various compounds, including flavonoids, alkaloids, saponins, polysaccharides, phenols, phenylpropanoids, terpenoids, highlighting their multitarget mechanisms, such as modulating kinases phosphatases. The ability these compounds mitigate oxidative stress, inflammation, pathology while enhancing cognitive function underscores value anti-Alzheimerʼs therapeutics. By integrating recent advances extraction methods, pharmacological studies, artificial intelligence-driven screening technologies, this provides valuable reference for future development product-based interventions disease.

Language: Английский

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Utilization of natural products in diverse pathogeneses of diseases associated with single or double DNA strand damage repair

Chinese Medicine, Journal Year: 2025, Volume and Issue: 20(1)

Published: April 7, 2025

Abstract The appearance of DNA damage often involves the participation related enzymes, which can affect onset and development various diseases. Several natural active compounds have been found to efficiently adjust activity crucial enzymes associated with single or double-strand damage, thus demonstrating their promise in treating This paper provides an in-depth examination summary these modulation mechanisms, leading a thorough review subject. connection between disease is explored through analysis structural characteristics compounds. By reviewing how different scholarly sources describe identical structures using varied terminology, this study also delves into effects on enzyme regulation. offers potentially be used therapeutically influence key activities expression levels, turn process repair (DDR). These shown not only reduce occurrence but boost efficiency processes, presenting new therapeutic opportunities for conditions such as cancer other pathologies. Future research should focus clarifying exact mechanisms maximize clinical utility support creation novel approaches prevention treatment. Graphical abstract

Language: Английский

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Cancer chemoprevention: signaling pathways and strategic approaches

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: April 17, 2025

Abstract Although cancer chemopreventive agents have been confirmed to effectively protect high-risk populations from invasion or recurrence, only over ten drugs approved by the U.S. Food and Drug Administration. Therefore, screening potent is crucial reduce constantly increasing incidence mortality rate of cancer. Considering lengthy prevention process, an ideal agent should be nontoxic, inexpensive, oral. Natural compounds become a natural treasure reservoir for chemoprevention because their superior ease availability, cost-effectiveness, safety. The benefits as in various studies. In light this, present review intended fully delineate entire scope chemoprevention, primarily focuses on aspects based compounds, specifically focusing mechanism action prevention, discussing detail how they exert effects affecting classical signaling pathways, immune checkpoints, gut microbiome. We also introduce novel strategies summarize role improving chemotherapy regimens. Furthermore, we describe discovering anticancer with low abundance high activity, revealing broad prospects drug discovery chemoprevention. Moreover, associate precision medicine, discuss challenges encountered Finally, emphasize transformative potential advancing field ability more effective less toxic preventive options oncology.

Language: Английский

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Therapeutic Potential of Natural Compounds to Modulate WNT/β-Catenin Signaling in Cancer: Current State of Art and Challenges

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 12804 - 12804

Published: Nov. 28, 2024

Targeted therapies and immunotherapies have improved the clinical outcome of cancer patients; however, efficacy treatment remains frequently limited due to low predictability response development drug resistance. Therefore, novel therapeutic strategies for various types are needed. Current research emphasizes potential value targeting WNT/β-catenin dependent signaling that is deregulated in types. Targeting pathway with diverse synthetic natural agents subject a number preclinical studies trials patients. The usage nature-derived attributed their health benefits, reduced toxicity side effects compared agents. review summarizes ongoing aim target components across spectrum types, highlighting improve treatment.

Language: Английский

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