PROTAC as a novel anti-cancer strategy by targeting aging-related signaling DOI
Yunhua Peng,

Donghua Liu,

Daoyuan Huang

et al.

Seminars in Cancer Biology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский

Ferroptosis in Cancer Therapy: Mechanisms, Small Molecule Inducers, and Novel Approaches DOI Creative Commons

YiLin Luo,

Xin Yue Bai,

L.J. Zhang

et al.

Drug Design Development and Therapy, Journal Year: 2024, Volume and Issue: Volume 18, P. 2485 - 2529

Published: June 1, 2024

Abstract: Ferroptosis, a unique form of programmed cell death, is initiated by an excess iron accumulation and lipid peroxidation-induced damage. There growing body evidence indicating that ferroptosis plays critical role in the advancement tumors. The increased metabolic activity higher levels tumor cells make them particularly vulnerable to ferroptosis. As result, targeted induction becoming increasingly promising approach for cancer treatment. This review offers overview regulatory mechanisms ferroptosis, delves into mechanism action traditional small molecule inducers their effects on various In addition, latest progress inducing using new means such as proteolysis-targeting chimeras (PROTACs), photodynamic therapy (PDT), sonodynamic (SDT) nanomaterials summarized. Finally, this discusses challenges opportunities development ferroptosis-inducing agents, focusing discovering targets, improving selectivity, reducing toxic side effects. Keywords: inducers, molecules, PROTACs, PDT, SDT,

Language: Английский

Citations

9
Application of PROTACs in target identification and validation DOI Creative Commons

Yang Liu,

Jing Liang,

Rui Zhu

et al.

Acta Materia Medica, Journal Year: 2024, Volume and Issue: 3(1)

Published: Jan. 1, 2024

PROTAC, as a novel therapeutic drug model, has received widespread attention from the academic and pharmaceutical industries. At same time, PROTAC technology led many researchers to focus on developing chemical biology tool properties due its unique operating mechanism protein dynamic regulatory properties. In recent years, rapid development of gradually made it an essential for target identification validation. To further promote application tools in discovery basic medical sciences research, this review distinguished between validation concepts. It summarized research progress these aspects.

Language: Английский

Citations

6
New curcumin derivative induces ferroptosis in MCF-7 cells through activating SLC7A11/GPX4 axis DOI
Zhiwen Wu, Guoqiang Zhang,

Yifan Shang

et al.

Bioorganic & Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 118078 - 118078

Published: Jan. 1, 2025

Language: Английский

Citations

0
Targeting glucocorticoid receptor signaling pathway for treatment of stress-related brain disorders DOI Creative Commons
Tansu Göver, Michał Ślęzak

Pharmacological Reports, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 3, 2024

Language: Английский

Citations

3
A prospective therapeutic strategy: GPX4-targeted ferroptosis mediators DOI

Jia-Yu Qian,

Chao-Yuan Lou,

Yili Chen

et al.

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 281, P. 117015 - 117015

Published: Oct. 30, 2024

Language: Английский

Citations

1
An overview of GPX4-targeting TPDs for cancer therapy DOI
Xiaojuan Yang, Liqiang Wu,

Shaohong Xu

et al.

Bioorganic & Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 118, P. 118046 - 118046

Published: Dec. 15, 2024

Language: Английский

Citations

1
Multi-Dimensional Analysis of the Regulatory Network of Ferroptosis in Osteoarthritis: Progress, Challenges, and Future Directions DOI

Shenglin Xia,

Ziliang Wang,

Yu He

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

0
PROTAC as a novel anti-cancer strategy by targeting aging-related signaling DOI
Yunhua Peng,

Donghua Liu,

Daoyuan Huang

et al.

Seminars in Cancer Biology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский

Citations

0