Highly sensitive detection of DNA methyltransferase1 triggered by methylation protection DOI
Miao He, Yan Chen,

Feifan Yin

et al.

Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: unknown, P. 136728 - 136728

Published: Oct. 1, 2024

Language: Английский

Phytochemical synergies in BK002: advanced molecular docking insights for targeted prostate cancer therapy DOI Creative Commons
Moon Nyeo Park, Jinwon Choi, Md. Maharub Hossain Fahim

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 17, 2025

Achyranthes japonica (Miq.) Nakai (AJN) and Melandrium firmum (Siebold Zucc.) Rohrb. (MFR) are medicinal plants recognized for their bioactive phytochemicals, including ecdysteroids, anthraquinones, flavonoids. This study investigates the anticancer properties of key constituents these plants, focusing on BK002 formulation, a novel combination AJN MFR. Specifically, research employs advanced molecular docking in silico analyses to assess interactions compounds ecdysterone, inokosterone, 20-hydroxyecdysone (20-HE) with prostate cancer-related network proteins, 5α-reductase, CYP17, DNMT1, Dicer, PD-1, PD-L1. Molecular techniques were applied evaluate binding affinities contributions against cancer-hub targets. The primary focus was enzymes like 5α-reductase which central androgen biosynthesis, as well proteins such DNA methyltransferase 1 (DNMT1), programmed death-1 (PD-1), death ligand-1 (PD-L1). Based data from cancer patients, target networks identified, followed by analysis components BK002.In assessments conducted safety profiles compounds, providing insights into therapeutic potential. studies revealed that 20-hydroxyecdysonec demonstrated strong critical contributing potential reduction androgenic activity. These also exhibited significant inhibitory PD-L1, suggesting capacity interfere oncogenic immune evasion pathways. Ecdysterone, have ability pathways, favorable affinity further underscore agents cancer. findings provide rationale preclinical clinical investigations, supporting integration regimens aimed at modulating tumor progression responses.

Language: Английский

Citations

1
Thiolated Layered Double Hydroxide-Based Nanoparticles: A Study on Mucoadhesiveness and Cytotoxicity DOI
Sema Şentürk, Özlem Kaplan, Kevser Bal

et al.

Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2024, Volume and Issue: unknown, P. 135461 - 135461

Published: Sept. 1, 2024

Language: Английский

Citations

4
Fucoxanthin supplemented combinatorial treatment accelerates diabetic wound healing in rats by targeting hypermethylation of Ang-1 promoter via DNMT-1 inhibition DOI

K. Saravanan,

Reena Rajkumari Baskaran

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 187, P. 118148 - 118148

Published: May 12, 2025

Language: Английский

Citations

0
Highly sensitive detection of DNA methyltransferase1 triggered by methylation protection DOI
Miao He, Yan Chen,

Feifan Yin

et al.

Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: unknown, P. 136728 - 136728

Published: Oct. 1, 2024

Language: Английский

Citations

0