Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: unknown, P. 136728 - 136728
Published: Oct. 1, 2024
Language: Английский
Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: unknown, P. 136728 - 136728
Published: Oct. 1, 2024
Language: Английский
Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16
Published: Feb. 17, 2025
Achyranthes japonica (Miq.) Nakai (AJN) and Melandrium firmum (Siebold Zucc.) Rohrb. (MFR) are medicinal plants recognized for their bioactive phytochemicals, including ecdysteroids, anthraquinones, flavonoids. This study investigates the anticancer properties of key constituents these plants, focusing on BK002 formulation, a novel combination AJN MFR. Specifically, research employs advanced molecular docking in silico analyses to assess interactions compounds ecdysterone, inokosterone, 20-hydroxyecdysone (20-HE) with prostate cancer-related network proteins, 5α-reductase, CYP17, DNMT1, Dicer, PD-1, PD-L1. Molecular techniques were applied evaluate binding affinities contributions against cancer-hub targets. The primary focus was enzymes like 5α-reductase which central androgen biosynthesis, as well proteins such DNA methyltransferase 1 (DNMT1), programmed death-1 (PD-1), death ligand-1 (PD-L1). Based data from cancer patients, target networks identified, followed by analysis components BK002.In assessments conducted safety profiles compounds, providing insights into therapeutic potential. studies revealed that 20-hydroxyecdysonec demonstrated strong critical contributing potential reduction androgenic activity. These also exhibited significant inhibitory PD-L1, suggesting capacity interfere oncogenic immune evasion pathways. Ecdysterone, have ability pathways, favorable affinity further underscore agents cancer. findings provide rationale preclinical clinical investigations, supporting integration regimens aimed at modulating tumor progression responses.
Language: Английский
Citations
1Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2024, Volume and Issue: unknown, P. 135461 - 135461
Published: Sept. 1, 2024
Language: Английский
Citations
4Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 187, P. 118148 - 118148
Published: May 12, 2025
Language: Английский
Citations
0Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: unknown, P. 136728 - 136728
Published: Oct. 1, 2024
Language: Английский
Citations
0