Synthesis and Cytostatic Activity of Substituted Derivatives of Sodium 1-Amino-2-cyano-1,6-dioxo-4-{[3-(ethoxycarbonyl)thiophen-2-yl]amino}hexa-2,4-dien-3-olates DOI
I. A. Gorbunova, K. A. Mitusova, K. Yu. Parkhoma

et al.

Russian Journal of General Chemistry, Journal Year: 2024, Volume and Issue: 94(12), P. 3140 - 3148

Published: Dec. 1, 2024

Language: Английский

Electrochemically Driven Ugi-Azide Reaction via C(sp3)–H Bond Activation of Tertiary Amines DOI
Bin Song, Feng Zhao,

Pengxiang Gao

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: 27(6), P. 1561 - 1567

Published: Jan. 31, 2025

An electrochemically driven Ugi-azide reaction was established via C(sp3)-H bond activation of tertiary amines to prepare α-aminomethyl tetrazoles within 2.5 h under mild conditions with remarkable tolerance various functional groups. Besides, this electrochemical strategy not only obviated the needs iodine, metal, and exogenous oxidant but possessed potential applicability convenient large-scale synthesis. Mechanistic studies indicated both alkyl carbon-centered radical generated at anode intramolecular [3 + 2] cycloaddition are key factors for strategy.

Language: Английский

Citations

0
Fe3O4@SiO2-LY-C-D-Pd as a new, effective, and magnetically recoverable catalyst for the synthesis of 1H-tetrazoles and asymmetric biphenyls DOI Creative Commons

Shelesh krishna saraswat,

Ahmed M. Naglah, Jayanti Makasana

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 15, 2025

Abstract This research project explored the synthesis and characterization of a newly developed C-D-Pd complex immobilized on Fe 3 O 4 @SiO 2 -LY, designed as reusable magnetic catalyst. The heterogeneous nanocatalyst was thoroughly characterized using EDS, FTIR, XRD, XPS, TGA, SEM, VSM, ICP techniques. -LY-C-D-Pd catalyst demonstrates exceptional performance in catalyzing C–C coupling reactions 1 H-tetrazole derivatives, achieving high product yields. offers several advantages, including eco-friendly reaction conditions, minimal usage, simple experimental setup, elimination harmful organic solvents, reduced times, ability to accommodate diverse substrates. Additionally, is easily separable from mixture can be reused multiple times without losing stability or catalytic efficiency.

Language: Английский

Citations

0
Green synthesis, characterization, in silico molecular docking and biological evaluation of imidazolylchalcones as promising fungicide/s and nematicide/s DOI Creative Commons
Rakesh Kumar, Parshant Kaushik,

Kailashpati Tripathi

et al.

BMC Chemistry, Journal Year: 2025, Volume and Issue: 19(1)

Published: April 29, 2025

Chalcones are known for their broad biological activities, which can be enhanced by incorporating heterocyclic moieties. Imidazole, recognized its diverse properties, was introduced into a series of imidazolylchalcone derivatives (3a-3o) synthesized via Claisen-Schmidt condensation benzaldehydes (2a-2o) and 4-(Imidazol-1-yl) acetophenone (1a) using ultrasonication as green method. These compounds were characterized spectroscopic techniques such 1H-NMR, 13C-NMR, LC-HRMS evaluated fungicidal nematicidal activity. Compound 3 h showed highest activity against Rhizoctonia solani (ED₅₀ = 0.69 μg/mL), outperforming commercial hexaconazole 3.57 μg/mL). 3d exhibited the Fusarium oxysporum 119.22 while 3f most effective Meloidogyne incognita (LC₅₀ 33.62 though less active than Velum Prime 3.46 The potential may results from interactions electronegative atom with enzyme sites hydrogen bonding. Docking studies fungal cutinase nematode acetylcholinesterase supported in-vitro findings. Promising will undergo further in-vivo field trials antifungal antinemic applications developed potent molecule.

Language: Английский

Citations

0
Organic Peroxides in Transition-Metal-Free Cyclization and Coupling Reactions (C–C) via Oxidative Transformation DOI Creative Commons
Amin Rezaeifard, Fatemeh Doraghi, Fatemeh Akbari

et al.

ACS Omega, Journal Year: 2025, Volume and Issue: unknown

Published: April 14, 2025

Transition-metal-free transformations are recognized as green and sustainable methods for constructing carbon-carbon bonds in organic synthesis. This review describes the application of six peroxides, including tert-butyl hydroperoxide (TBHP), di-tert-butyl peroxide (DTBP), peroxybenzoate (TBPB), benzoyl (BPO), dialauroyl (DLP), diguyl (DCP), C-C bond construction, highlighting selected examples mechanisms challenging transformations. Each section concludes with a detailed overview suitable reagents various coupling reactions strengths weaknesses reported works. work aims to inspire further innovations transition-metal-free oxidative transformations, promoting eco-friendly chemical processes paving way new peroxide-based synthesis methods.

Language: Английский

Citations

0
Development of novel tetrazole-based pyruvate kinase M2 inhibitors targeting U87 glioblastoma cells DOI

Moumita Ghosh Chowdhury,

Saumya Kapoor,

Venkatesh Muthukumar

et al.

Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 154, P. 108029 - 108029

Published: Dec. 5, 2024

Language: Английский

Citations

1
Brønsted acid-catalyzed selective alkylation of tetrazoles with acetone DOI
Chunyan Li, Tonghui Zhang,

Menghua Dong

et al.

Tetrahedron Letters, Journal Year: 2024, Volume and Issue: 151, P. 155327 - 155327

Published: Oct. 15, 2024

Language: Английский

Citations

0
Synthesis and Cytostatic Activity of Substituted Derivatives of Sodium 1-Amino-2-cyano-1,6-dioxo-4-{[3-(ethoxycarbonyl)thiophen-2-yl]amino}hexa-2,4-dien-3-olates DOI
I. A. Gorbunova, K. A. Mitusova, K. Yu. Parkhoma

et al.

Russian Journal of General Chemistry, Journal Year: 2024, Volume and Issue: 94(12), P. 3140 - 3148

Published: Dec. 1, 2024

Language: Английский

Citations

0