Artificial Intelligence in Pharmaceutical Technology and Drug Delivery Design

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(7), P. 1916 - 1916

Published: July 10, 2023

Artificial intelligence (AI) has emerged as a powerful tool that harnesses anthropomorphic knowledge and provides expedited solutions to complex challenges. Remarkable advancements in AI technology machine learning present transformative opportunity the drug discovery, formulation, testing of pharmaceutical dosage forms. By utilizing algorithms analyze extensive biological data, including genomics proteomics, researchers can identify disease-associated targets predict their interactions with potential candidates. This enables more efficient targeted approach thereby increasing likelihood successful approvals. Furthermore, contribute reducing development costs by optimizing research processes. Machine assist experimental design pharmacokinetics toxicity capability prioritization optimization lead compounds, need for costly animal testing. Personalized medicine approaches be facilitated through real-world patient leading effective treatment outcomes improved adherence. comprehensive review explores wide-ranging applications delivery form designs, process optimization, testing, pharmacokinetics/pharmacodynamics (PK/PD) studies. an overview various AI-based utilized technology, highlighting benefits drawbacks. Nevertheless, continued investment exploration industry offer exciting prospects enhancing processes care.

Language: Английский

---

Nanoparticle-Based Delivery Systems for Vaccines

Vaccines, Journal Year: 2022, Volume and Issue: 10(11), P. 1946 - 1946

Published: Nov. 17, 2022

Vaccination is still the most cost-effective way to combat infectious illnesses. Conventional vaccinations may have low immunogenicity and, in situations, only provide partial protection. A new class of nanoparticle-based has shown considerable promise addressing majority shortcomings traditional and subunit vaccines. This due recent breakthroughs chemical biological engineering, which allow for exact regulation nanoparticle size, shape, functionality, surface characteristics, resulting improved antigen presentation robust immunogenicity. blend physicochemical, immunological, toxicological experiments can be used accurately characterize nanovaccines. narrative review will an overview current scenario nanovaccine.

Language: Английский

---

Nanocrystals as a master key to deliver hydrophobic drugs via multiple administration routes

Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 345, P. 334 - 353

Published: March 11, 2022

Language: Английский

---

Microneedle-Based Natural Polysaccharide for Drug Delivery Systems (DDS): Progress and Challenges

Pharmaceuticals, Journal Year: 2022, Volume and Issue: 15(2), P. 190 - 190

Published: Feb. 3, 2022

In this focused progress review, the most widely accepted methods of transdermal drug delivery are hypodermic needles, patches and topical creams. However, microneedles (MNs) (or microneedle arrays) low-invasive 3D biomedical constructs that bypass skin barrier produce systemic localized pharmacological effects. past, biomaterials such as carbohydrates, due to their physicochemical properties, have been extensively used manufacture (MNs). Due wide range functional groups, carbohydrates enable design development tunable properties functionalities. recent years, numerous products emerged on market, although much research needs be undertaken overcome various challenges before successful introduction into market. As a result, carbohydrate-based microarrays high potential achieve future step in sensing, delivery, biologics restitution. comprehensive overview hyaluronic acid, chitin, chitosan, chondroitin sulfate, cellulose starch is discussed systematically. It also discusses strategies mechanical biomaterial-based MNs, made so far clinical translation promotional opportunities for commercialization. conclusion, article summarizes perspectives which considered new class systems.

Language: Английский

---

Recent Advancements in Microneedle Technology for Multifaceted Biomedical Applications

Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(5), P. 1097 - 1097

Published: May 20, 2022

Microneedle (MNs) technology is a recent advancement in biomedical science across the globe. The current limitations of drug delivery, like poor absorption, low bioavailability, inadequate skin permeation, and biodistribution, can be overcome by MN-based delivery. Nanotechnology made significant changes fabrication techniques for microneedles design shifted from conventional to novel, using various types natural synthetic materials their combinations. Nowadays, MNs has gained popularity worldwide research delivery due its multifaceted broad-spectrum applications. This review broadly discusses MN's types, methods, composition, characterization, applications, advancements, global intellectual scenarios.

Language: Английский

---

Hollow microneedle assisted intradermal delivery of hypericin lipid nanocapsules with light enabled photodynamic therapy against skin cancer

Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 348, P. 849 - 869

Published: June 28, 2022

Photodynamic therapy (PDT) to manage non-melanoma skin cancers has garnered great attention over the past few years. Hypericin (Hy) is a potent lipid-soluble photosensitiser with promising anticancer therapeutic activities. Nevertheless, its poor water-solubility, aggregation in biological systems and insufficient penetration restricted effective exploitation. Herein, we report for first-time encapsulation of Hy into lipid nanocapsules (Hy-LNCs), then application an AdminPen™ hollow microneedles (Ho-MNs) array in-house fabricated Ho-MN enable efficient intradermal delivery. The physicochemical properties, photoactivity, ex vivo drug distribution cellular uptake were evaluated. Results showed that Hy-LNCs successfully formed particle size 47.76 ± 0.49 nm, PDI 0.12 0.02, high efficiency (99.67% 0.35), 396 fold higher 7 deposition, significantly greater photocytotoxicity compared free Hy. effect was finally assessed using nude mouse model transplanted tumours. Interestingly, delivered by exhibited remarkable anti-tumour destruction (85.84%) after irradiation 595 nm. This study Ho-MNs-driven delivery followed could form minimally invasive, site-specific approach managing cancers.

Language: Английский

---

Dissolvable polymer microneedles for drug delivery and diagnostics

Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 347, P. 561 - 589

Published: May 24, 2022

Language: Английский

---

Solid implantable devices for sustained drug delivery

Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 199, P. 114950 - 114950

Published: June 7, 2023

Implantable drug delivery systems (IDDS) are an attractive alternative to conventional administration routes. Oral and injectable the most common routes for providing peaks of concentrations in blood after followed by concentration decay a few hours. Therefore, constant is required keep levels within therapeutic window drug. Moreover, oral presents challenges due degradation gastrointestinal tract or first pass metabolism. IDDS can be used provide sustained prolonged periods time. The use this type especially interesting treatment chronic conditions where patient adherence treatments challenging. These normally systemic delivery. However, localised maximise amount delivered active site while reducing exposure. This review will cover current applications focusing on materials prepare main areas application.

Language: Английский

---

Microneedle-based biosensing

Nature Reviews Bioengineering, Journal Year: 2023, Volume and Issue: 2(1), P. 64 - 81

Published: Sept. 26, 2023

Language: Английский

---

Microneedle-Mediated Transdermal Delivery of Biopharmaceuticals

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(1), P. 277 - 277

Published: Jan. 13, 2023

Transdermal delivery provides numerous benefits over conventional routes of administration. However, this strategy is generally limited to a few molecules with specific physicochemical properties (low molecular weight, high potency, and moderate lipophilicity) due the barrier function stratum corneum layer. Researchers have developed several physical enhancement techniques expand applications transdermal field; among these, microneedle technology has recently emerged as promising platform deliver therapeutic agents any size into across skin. Typically, hydrophilic biomolecules cannot penetrate skin by passive diffusion. Microneedle insertion disrupts integrity compromises its protective function, thus creating pathways (microchannels) for enhanced permeation macromolecules. Microneedles not only improve stability but also enhance various biomolecules. Academic institutions industrial companies invested substantial resources in development systems biopharmaceutical delivery. This review article summarizes most recent research provide comprehensive discussion about microneedle-mediated macromolecules, covering topics from introduction skin, delivery, microneedles, biopharmaceuticals (current status, administration, issues), different types, clinical trials, safety acceptability manufacturing regulatory issues, future technology.

Language: Английский

---