Journal of Molecular Liquids, Journal Year: 2024, Volume and Issue: unknown, P. 126541 - 126541
Published: Nov. 1, 2024
Language: Английский
Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(7), P. 1916 - 1916
Published: July 10, 2023
Artificial intelligence (AI) has emerged as a powerful tool that harnesses anthropomorphic knowledge and provides expedited solutions to complex challenges. Remarkable advancements in AI technology machine learning present transformative opportunity the drug discovery, formulation, testing of pharmaceutical dosage forms. By utilizing algorithms analyze extensive biological data, including genomics proteomics, researchers can identify disease-associated targets predict their interactions with potential candidates. This enables more efficient targeted approach thereby increasing likelihood successful approvals. Furthermore, contribute reducing development costs by optimizing research processes. Machine assist experimental design pharmacokinetics toxicity capability prioritization optimization lead compounds, need for costly animal testing. Personalized medicine approaches be facilitated through real-world patient leading effective treatment outcomes improved adherence. comprehensive review explores wide-ranging applications delivery form designs, process optimization, testing, pharmacokinetics/pharmacodynamics (PK/PD) studies. an overview various AI-based utilized technology, highlighting benefits drawbacks. Nevertheless, continued investment exploration industry offer exciting prospects enhancing processes care.
Language: Английский
Citations
398
Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 201, P. 115055 - 115055
Published: Aug. 17, 2023
The minimally-invasive and painless nature of microneedle (MN) application has enabled the technology to obviate many issues with injectable drug delivery. MNs not only administer therapeutics directly into dermal ocular space, but they can also control release profile active compound over a desired period. To enable prolonged delivery payloads, various MN types have been proposed evaluated, including dissolving MNs, polymeric loaded or coated nanoparticles, fast-separable hollow hydrogel MNs. These intricate yet intelligent platforms provide an attractive approach decrease side effects administration frequency, thus offer potential increase patient compliance. In this review, formulations that are for long-acting address clinical needs myriad diseases discussed. We highlight design aspects, such as polymer selection geometry, in addition computational mathematical modeling necessary help streamline develop high translational value impact. Finally, up-scale manufacturing regulatory hurdles along avenues require further research bring market carefully considered. It is hoped review will insight formulators clinicians judicious materials tandem refined may elegant achieve sustained payloads through simple patch.
Language: Английский
Citations
54
Polymers, Journal Year: 2024, Volume and Issue: 16(18), P. 2606 - 2606
Published: Sept. 14, 2024
Poly(lactic-co-glycolic acid) (PLGA) is a widely used biodegradable and biocompatible copolymer in drug delivery systems (DDSs). In this article, we highlight the critical physicochemical properties of PLGA, including its molecular weight, intrinsic viscosity, monomer ratio, blockiness, end caps, that significantly influence release profiles degradation times. This review also covers extensive literature on application PLGA delivering small-molecule drugs, proteins, peptides, antibiotics, antiviral drugs. Furthermore, discuss role PLGA-based DDSs treating various diseases, cancer, neurological disorders, pain, inflammation. The incorporation drugs into nanoparticles microspheres has been shown to enhance their therapeutic efficacy, reduce toxicity, improve patient compliance. Overall, holds great promise for advancement treatment management multiple chronic conditions.
Language: Английский
Citations
19
Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 371, P. 43 - 66
Published: May 22, 2024
Microneedles (MNs) are micron-sized needles, typically <2 mm in length, arranged either as an array or single needle. These MNs offer a minimally invasive approach to ocular drug delivery due their micron size (reducing tissue damage compared that of hypodermic needles) and overcoming significant barriers administration. While various types have been extensively researched, progress has made the use hollow (HMNs) for delivery, specifically through suprachoroidal injections. The space, situated between sclera choroid, targeted using optical coherence tomography-guided injections HMNs treatment uveitis. Unlike other MNs, can deliver larger volumes formulations eye. This review primarily focuses on explores anatomy distribution following potential HMN administration routes. Additionally, this influence formulation characteristics (e.g., solution viscosity, particle size), properties bore lumen diameter, MN length), routes periocular transscleral, suprachoroidal, intravitreal) drugs. Overall, paper highlights distinctive HMNs, which make them promising technology improving efficiency, precision, patient outcomes diseases.
Language: Английский
Citations
16
ACS Omega, Journal Year: 2025, Volume and Issue: 10(1), P. 1207 - 1225
Published: Jan. 3, 2025
Manufacturing bioactive materials for drug delivery involves developing that interact with biological tissues to release drugs in a controlled and targeted manner. The goal is optimize therapeutic efficacy reduce side effects by combining knowledge from engineering, biology, pharmacology. This study presents detailed bibliometric analysis, exploring the keywords "manufacturing," "bioactive materials," "drug delivery" identify highlight significant advancements field. From Web of Science, 36,504 articles were analyzed, 171 selected deeper identifying key journals, countries, institutions, authors. results field's interdisciplinary nature, grouped into four main themes, including regenerative medicine, scaffolds, three-dimensional (3D) printing, glass, tissue engineering. Future research this area will focus on more effective precise systems using technologies like 3D printing nanotechnology enhance customization control release, aiming efficient therapies.
Language: Английский
Citations
4
Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(1), P. 136 - 136
Published: Jan. 19, 2025
Nanosuspensions (NS), with their submicron particle sizes and unique physicochemical properties, provide a versatile solution for enhancing the administration of medications that are not highly soluble in water or lipids. This review highlights recent advancements, future prospects, challenges NS-based drug delivery, particularly oral, ocular, transdermal, pulmonary, parenteral routes. The conversion oral NS into powders, pellets, granules, tablets, capsules, incorporation film dosage forms to address stability concerns is thoroughly reviewed. article summarizes key stabilizers, polymers, surfactants, excipients used formulations, along ongoing clinical trials patents. Furthermore, comprehensive analysis various methods preparation provided. also explores vitro vivo characterization techniques, as well scale-down technologies bottom-up preparation. Selected examples commercial products discussed. Rapid advances field could resolve issues related permeability-limited absorption hepatic first-pass metabolism, offering promise based on proteins peptides. evolution novel stabilizers essential overcome current limitations stability, bioavailability, targeting ability, safety profile, which ultimately accelerates application commercialization.
Language: Английский
Citations
3
Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 200, P. 115003 - 115003
Published: July 6, 2023
Language: Английский
Citations
35
Polymer-Plastics Technology and Materials, Journal Year: 2024, Volume and Issue: 63(6), P. 680 - 702
Published: Jan. 10, 2024
The emergence of Polyether Ether Ketone (PEEK) in implant fabrication is a sign the revolution healthcare that has been sparked by convergence 3D printing technology and advanced materials. This review paper investigates multifaceted impact PEEK on changing manufacturing landscape. explores significance fabrication, critical function printing, as leading material through thorough analysis PEEK's exceptional biocompatibility, mechanical properties, adaptability. It various PEEK-based applications dental, orthopedic, spinal, cranial, cardiovascular, emerging domains, supported real-world case studies success stories. also discusses difficulties, developments, sustainability issues related to printing. revolutionary highlighted this paper, which charts future directions provides insights into how patient care paradigm implantology.
Language: Английский
Citations
14
Journal of Industrial and Engineering Chemistry, Journal Year: 2024, Volume and Issue: 137, P. 61 - 86
Published: March 22, 2024
Language: Английский
Citations
14
Advanced Drug Delivery Reviews, Journal Year: 2024, Volume and Issue: 209, P. 115325 - 115325
Published: April 24, 2024
Language: Английский
Citations
12