Existing
long-acting
patches
usually
use
controlled-release
membranes
to
achieve
constant
rate
delivery
of
the
drug,
which
is
complex
and
costly
prepare
due
5-layer
structure,
so
there
a
necessity
develop
method
simplify
patch
design
control
drug
delivery.
This
study
prepared
7-day
clonidine
(CLO)
using
ion-pair
strategy
based
on
hydroxyphenyl-modified
pressure-sensitive
adhesive
(HP-PSA)
clarified
molecular
mechanism
controlled
Single
factorial
central
composite
(CCD)
experiments
were
used
optimize
formulation,
was
evaluated
by
pharmacokinetic
study.
The
investigated
FTIR,
1H-NMR,
differential
scanning
calorimetry
(DSC),
confocal
laser
microscopy
(CLSM),
modeling,
rheology
optimized
formulated
with
4.80%
(w/w)
CLO-AA
(azelaic
acid)
as
API
HP-PSA
PSA
matrix
95.00μm
thickness.
single-layer
not
only
simplifies
preparation
process
but
also
has
zero-level
skin
penetration
profile
(r=0.9592)
in
vitro.
Compared
commercial
(AUC0-t=7748.51±662.76
h
ng/ml,
MRT0-t=71.04±9.30h),
behavior
optimization
group
semblable
(AUC0-t=8160.28±694.04
MRT0-t=63.19±12.38h).
Mechanistic
studies
showed
that
improved
interaction
HP-PSA,
leading
release.
Changes
physicochemical
properties
decreased
permeability
increased
drug-skin
interaction,
resulting
rate.
In
conclusion,
CLO
achieved
strategy,
simplified
process,
inspired
transdermal
system.
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(4), P. 480 - 480
Published: April 1, 2024
Rheumatoid
arthritis
(RA)
is
a
chronic
autoimmune
disease
that
leads
to
deformities
and
disabilities
in
patients.
Conventional
treatment
focuses
on
delaying
progression;
therefore,
new
treatments
are
necessary.
The
present
study
reported
novel
ionic
liquid
transdermal
platform
for
efficient
RA
treatment,
the
underlying
mechanism
was
elucidated
using
FTIR,
1H-NMR,
Raman,
XPS,
molecular
simulations.
results
showed
reversibility
of
semi-ionic
hydrogen
bonding
facilitated
high
drug
loading
enhanced
permeability.
Actarit’s
had
an
approximately
11.34-times
increase.
vitro
permeability
actarit
ketoprofen
improved
by
5.46
2.39
times,
respectively.
And
they
same
significant
effect
vivo.
Furthermore,
through
integration
network
pharmacology,
Western
blotting
(WB),
radiology
analyses,
osteoprotective
effects
SIHDD-PSA
(semi-ionic
H-bond
double-drug
pressure-sensitive
adhesive
patch)
were
revealed
modulation
JAK-STAT
pathway.
significantly
reduced
paw
swelling
inflammation
rat
model,
stimulatory
properties
evaluation
confirmed
safety
SIHDD-PSA.
In
conclusion,
these
findings
provide
approach
effective
RA,
strategy
contributes
theoretical
basis
developing
TDDS.
Expert Opinion on Drug Delivery,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 29, 2025
Transdermal
patches
offer
a
unique
advantage
by
providing
extended
therapeutic
benefits
while
maintaining
stable
plasma
drug
concentration.
The
efficacy
and
safety
of
depend
significantly
on
their
ability
to
adhere
the
skin,
feature
influenced
various
external
internal
factors.
review
primarily
focuses
fundamental
aspects
adhesion
in
transdermal
patches,
including
basic
information
about
underlying
principles
adhesion,
delivery,
characteristics
pressure
sensitive
adhesives
(PSAs),
issues,
impact
factors,
strategies
improve
patch
relevant
molecular
mechanisms.
development
with
sufficient
for
consistent
delivery
remains
challenging
task.
Challenges
stem
from
complex
interplay
among
PSAs,
permeation
enhancers,
active
pharmaceutical
ingredients
(APIs),
other
excipients
current
compositions,
further
complicated
variations
arising
dermatological
These
intricacies
impede
effectiveness
patches.
Progress
exploration
new
PSA
polymers,
conjunction
innovative
is
crucial
establishing
an
optimal
equilibrium
between
utilization
rate,
drug-loading,
release,
thus
effectively
addressing
challenges
related
adhesion.
