International Journal of Applied Ceramic Technology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 31, 2024
Abstract
This
study
modifies
the
hydration
process
of
hydrated
magnesium
carboxylate
(HMC)
by
organic
acids
to
improve
workability
HMC‐bonded
castables
(HMCC),
while
comprehensively
analyzing
effects
on
mechanical
properties
and
thermal
shock
resistance
HMCC.
Results
demonstrate
that
lactic
acid
significantly
increases
setting
time
rheology
HMCC
738%
217.8%,
respectively.
is
due
inhibiting
HMC
ionization
delaying
hydration,
as
evidenced
kinetics
experiments.
Furthermore,
could
also
reduce
degree
polymerization
products.
Notably,
cold
modulus
rupture
593.7%,
100%,
95.7%
at
500°C,
800°C,
1100°C,
performance
improvement
attributed
acid's
promotion
sintering
HMCC,
possibly
its
effect
improving
castable
uniformity.
However,
results
in
an
18.1%
reduction
green
body
strength,
potentially
weakened
three‐dimensional
network
structure
Additionally,
residual
strength
ratio
4.3%
enhances
crack
propagation
(
R
‴)
45%.
These
improvements
result
from
optimized
microstructure,
characterized
smaller,
more
uniformly
distributed
particles
with
regular
shapes
tighter
interparticle
connections.
Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(3), P. 375 - 375
Published: March 15, 2025
Recent
progress
in
material
science
has
led
to
the
development
of
new
drug
delivery
systems
that
go
beyond
conventional
approaches
and
offer
greater
accuracy
convenience
application
therapeutic
agents.
This
review
discusses
evolutionary
role
nanocarriers,
hydrogels,
bioresponsive
polymers
enhanced
release,
target
accuracy,
bioavailability.
Oncology,
chronic
disease
management,
vaccine
are
some
applications
explored
this
paper
show
how
these
materials
improve
results,
counteract
multidrug
resistance,
allow
for
sustained
localized
treatments.
The
also
translational
barriers
bringing
advanced
into
clinical
setting,
which
include
issues
biocompatibility,
scalability,
regulatory
approval.
Methods
overcome
challenges
surface
modifications
reduce
immunogenicity,
scalable
production
methods
such
as
microfluidics,
harmonization
systems.
In
addition,
convergence
artificial
intelligence
(AI)
machine
learning
(ML)
is
opening
frontiers
personalized
medicine.
These
technologies
predictive
modeling
real-time
adjustments
optimize
needs
individual
patients.
use
can
be
applied
rare
underserved
diseases;
thus,
strategies
gene
therapy,
orphan
drugs
development,
global
distribution
may
hopes
millions
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(23), P. 13121 - 13121
Published: Dec. 6, 2024
The
bioavailability
of
small-molecule
drugs
remains
a
critical
challenge
in
pharmaceutical
development,
significantly
impacting
therapeutic
efficacy
and
commercial
viability.
This
review
synthesizes
recent
advances
understanding
overcoming
limitations,
focusing
on
key
physicochemical
biological
factors
influencing
drug
absorption
distribution.
We
examine
cutting-edge
strategies
for
enhancing
bioavailability,
including
innovative
formulation
approaches,
rational
structural
modifications,
the
application
artificial
intelligence
design.
integration
nanotechnology,
3D
printing,
stimuli-responsive
delivery
systems
are
highlighted
as
promising
avenues
improving
delivery.
discuss
importance
holistic,
multidisciplinary
approach
to
optimization,
emphasizing
early-stage
consideration
ADME
properties
need
patient-centric
also
explores
emerging
technologies
such
CRISPR-Cas9-mediated
personalization
microbiome
modulation
tailored
enhancement.
Finally,
we
outline
future
research
directions,
advanced
predictive
modeling,
barriers,
addressing
challenges
modalities.
By
elucidating
complex
interplay
affecting
this
aims
guide
efforts
developing
more
effective
accessible
therapeutics.
Cancers,
Journal Year:
2024,
Volume and Issue:
16(24), P. 4234 - 4234
Published: Dec. 19, 2024
Cancer
remains
a
predominant
global
health
concern,
necessitating
effective
treatment
options.
Conventional
cancer
therapies,
particularly
chemotherapy,
often
face
constraints
such
as
low
selectivity,
insufficient
solubility,
and
multidrug
resistance
(MDR),
which
diminish
effectiveness
exacerbate
negative
effects.
Metal
oxide
nanoparticles
(MONPs),
iron
oxide,
zinc
copper
offer
promising
solution
by
enhancing
targeted
drug
delivery,
reducing
systemic
toxicity,
mitigating
chemotherapy-induced
disabilities
like
neurotoxicity
cardiotoxicity.
Nanocarriers
conjugated
with
drugs
can
improve
delivery
within
the
body
enhance
their
circulation
in
bloodstream.
Recent
advancements
MONP
synthesis
functionalization
have
further
improved
stability
drug-loading
capacity,
making
them
valuable
tool
treatment.
MONPs
distinctive
physicochemical
characteristics,
enabling
better
imaging,
encapsulation,
medication
to
cancerous
cells.
These
nanocarriers
through
focused
controlled
release,
off-target
effects
addressing
resistance.
This
review
aims
explore
potential
of
efficient
for
anticancer
drugs,
limitations
traditional
chemotherapy
poor
specificity,
Additionally,
discusses
recent
functionalization,
stability,
compatibility.
Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(2), P. 151 - 151
Published: Jan. 23, 2025
Background:
This
study
demonstrates
the
application
of
sequential
design
experiments
(DoE)
approach
within
quality
by
(QbD)
framework
to
optimize
extrusion
processes
through
screening,
optimization,
and
robustness
testing.
Methods:
An
in-line
UV–Vis
process
analytical
technology
(PAT)
system
was
successfully
employed
monitor
critical
attributes
(CQAs)
piroxicam
amorphous
solid
dispersion
(ASD)
products,
specifically
lightness
(L*).
Results:
L*
measurement
proved
highly
effective
for
ensuring
uniformity
ASDs,
offering
real-time
insights
into
their
physical
appearance
stability.
Small
variations
in
acted
as
early
indicators
processing
issues,
such
phase
separation
or
bubble
formation,
enabling
timely
intervention.
straightforward
rapid
technique
supports
monitoring
control,
allowing
automated
adjustments
maintain
product
consistency
quality.
By
adopting
this
strategy,
manufacturers
can
minimize
variability,
reduce
waste,
ensure
adherence
target
profiles
(QTPPs).
Conclusions:
Overall,
highlights
value
spectroscopy
a
PAT
tool
hot
melt
extrusion,
enhancing
CQA
assessment
advancing
efficiency
reliability
ASD
manufacturing.
Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(3), P. 283 - 283
Published: Feb. 20, 2025
Psoriasis
is
a
chronic
inflammatory
disease
with
complex
pathogenesis,
influenced
by
various
factors
involving
environment,
genes,
and
immunity.
The
main
symptoms
of
psoriasis
include
erythema,
scales,
itching,
etc.
At
present,
therapeutic
drugs
for
are
continually
evolving
towards
enhancing
treatment
efficacy
reducing
side
effects.
Firstly,
the
pathogenesis
characteristics
were
summarized.
Then,
types
benefits
topical
therapy
introduced,
such
as
aspects
avoiding
systemic
toxic
effects,
first
pass
effect,
gastrointestinal
reactions
accelerating
onset
time
improving
its
efficacy,
compared
to
drugs.
In
case
methotrexate,
cyclosporin
A,
Janus
kinase
(JAK)
inhibitors,
phosphodiesterase-4
(PDE-4)
this
review
had
further
discussion
on
improvement
translation
these
molecules
from
in
clinical
practice.
To
augment
limitation
skin
permeability,
nanotechnology
novel
drug
delivery
system
including
nanomedicines,
hydrogels,
ionic
liquids,
microneedles
elaborated
management.
Also,
exploration
targeting
pathogenic
genes
through
small
interfering
RNA
(siRNA)
using
nanoparticles
liquids
(ILs)
great
significance
long-term
psoriasis.
Taken
together,
development
numerous
platforms
expected
achieve
enhanced
penetration,
precise
efficient
molecule
interference
(RNAi)
therapeutics
prospects.
CrystEngComm,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Seven
new
salts
of
the
antihistamine
drug
bilastine
were
prepared
with
inorganic
acid
counter
ions
and
demonstrated
modified
solubility
&
dissolution
along
study
anti-cancer
activity
against
skin
cancer.
Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(3), P. 371 - 371
Published: March 14, 2025
Background:
Fluconazole
(FLZ)
is
a
broad-spectrum
anti-fungal
drug
presenting
poor
flowability,
mechanical
properties,
and
limited
aqueous
solubility.
These
issues
pose
challenges
for
the
handling
manufacturing
of
dosage
forms
FLZ.
The
current
research
aimed
to
develop
fluconazole
co-crystal
(CC)
improving
its
solubility,
properties.
(2)
Methods:
benzoic
acid
(FLZ-BA)
was
prepared
using
solvent
evaporation
technique.
characterized
content,
activity,
dissolution,
stability.
DSC
(Differential
Scanning
Calorimetry),
PXRD
(Powder
X-Ray
Diffraction),
SEM
(Scanning
Electron
Microscopy),
FTIR
(Fourier
Transmission
Infrared)
spectroscopy
were
carried
out
confirm
formation.
further
evaluated
their
flow
characteristics
properties
via
CTC
(compressibility,
tabletability,
compactibility),
Heckel,
Kawakita
analysis.
(3)
Results:
CC
showed
69.51%
content
13-fold
greater
solubility
than
pure
thermogram
sharp
endothermic
peak
between
parent
components,
distinct
pattern
observed,
analysis
revealed
different
morphology,
confirming
formation
(new
crystalline
form).
immediate
release
found
more
stable,
less
hygroscopic
FLZ
alone.
better
tabletability
(tensile
strength),
compressibility,
compactibility.
Moreover,
Heckel
indicated
deform
plastically,
favoring
improved
compression.
(4)
Conclusions:
capabilities,
stability,
antifungal
flowability
make
FLZ-BA
suitable
candidate
preparation
an
form.
study
also
application
