Journal of Agricultural and Food Chemistry,
Journal Year:
2021,
Volume and Issue:
69(17), P. 5226 - 5237
Published: April 23, 2021
Citrus
flavanones
have
the
potential
to
alleviate
atherosclerosis.
The
metabolism
and
anti-atherosclerosis
signaling
pathways
of
four
citrus
(naringin,
naringenin,
hesperidin,
hesperetin)
were
compared
in
ApoE-/-
mice.
Naringin
had
most
potent
anti-atherogenic
effect,
followed
by
hesperetin
with
reductions
55.92,
34.98,
42.87,
24.70%
atherosclerotic
plaque
rate
control,
respectively.
Oral
naringin
mainly
existed
intestine
due
high
water
solubility
7-O-nohesperidoside
alleviated
atherosclerosis
enhancing
bile
acid
synthesis
gut
microbiota-FXR/FGF15-CYP7A1
pathway.
other
three
liver
after
absorption
from
intestine.
Hesperidin
upregulates
ABCA1
1.8-fold
enhance
cholesterol
reverse
transport,
while
aglycones
naringenin
inhibited
via
downregulating
HMGCR
2.4-
2.3-fold,
Hesperetin
was
more
resistant
than
existence
a
4'-methoxyl
group
relatively
weak
effects
on
alleviation
tightly
related
differences
their
vivo
pathways.
This
provides
new
insights
into
anti-atherosclerotic
mechanisms
food
functional
guidance
for
design
novel,
efficient
strategies
preventing
based
flavanones.
Oxidative Medicine and Cellular Longevity,
Journal Year:
2021,
Volume and Issue:
2021(1)
Published: Jan. 1, 2021
Fibrosis
is
the
final
common
pathology
of
most
chronic
diseases
as
seen
in
heart,
liver,
lung,
kidney,
and
skin
contributes
to
nearly
half
death
developed
countries.
Fibrosis,
or
scarring,
mainly
characterized
by
transdifferentiation
fibroblasts
into
myofibroblasts
excessive
accumulation
extracellular
matrix
(ECM)
secreted
myofibroblasts.
Despite
immense
efforts
made
field
organ
fibrosis
over
past
decades
considerable
understanding
occurrence
development
gained,
there
still
lack
an
effective
treatment
for
fibrotic
diseases.
Therefore,
identifying
a
new
therapeutic
strategy
against
unmet
clinical
need.
Naringenin,
flavonoid
that
occurs
naturally
citrus
fruits,
has
been
found
confer
wide
range
pharmacological
effects
including
antioxidant,
anti-inflammatory,
anticancer
benefits
thus
potentially
exerting
preventive
curative
on
numerous
In
addition,
emerging
evidence
revealed
naringenin
can
prevent
pathogenesis
vivo
vitro
via
regulation
various
pathways
involved
signaling
molecules
such
transforming
growth
factor-β1/small
mother
decapentaplegic
protein
3
(TGF-β1/Smad3),
mitogen-activated
kinase
(MAPK),
phosphatidylinositol
3-kinase/protein
B
(PI3K/Akt),
sirtuin1
(SIRT1),
nuclear
factor-kappa
(NF-κB),
reactive
oxygen
species
(ROS).
Targeting
these
profibrotic
could
become
novel
approach
management
disorders.
this
review,
we
present
comprehensive
summary
antifibrotic
roles
their
underlying
mechanisms
action.
As
food
derived
compound,
may
serve
promising
drug
candidate
Critical Reviews in Food Science and Nutrition,
Journal Year:
2021,
Volume and Issue:
62(13), P. 3421 - 3436
Published: Jan. 4, 2021
Neurodegenerative
diseases
are
questions
that
modern
therapeutics
can
still
not
answer.
Great
milestones
have
been
achieved
regarding
liver,
heart,
skin,
kidney
and
other
types
of
organ
transplantations
but
the
greatest
drawback
is
adequate
supply
these
organs.
Furthermore,
there
a
few
options
available
in
treatment
neurodegenerative
diseases.
With
great
advances
medical
science,
many
health
problems
faced
by
humans
solved,
their
quality
life
improving.
Moreover,
were
incurable
past
now
fully
cured.
Still,
area
regenerative
medicine,
especially
concerning
neuronal
regeneration,
its
infancy.
Presently
allopathic
drugs,
surgical
procedures,
transplantation,
stem
cell
therapy
forms
core
therapy.
However,
times,
currently
used
therapies
cannot
completely
cure
damaged
organs
The
current
review
focuses
on
concepts
hurdles
path
therapy,
idea
using
peptides,
cytokines,
tissue
engineering,
genetic
advanced
polyphenolic
phytochemicals
to
tissues
Journal of Agricultural and Food Chemistry,
Journal Year:
2021,
Volume and Issue:
69(17), P. 5226 - 5237
Published: April 23, 2021
Citrus
flavanones
have
the
potential
to
alleviate
atherosclerosis.
The
metabolism
and
anti-atherosclerosis
signaling
pathways
of
four
citrus
(naringin,
naringenin,
hesperidin,
hesperetin)
were
compared
in
ApoE-/-
mice.
Naringin
had
most
potent
anti-atherogenic
effect,
followed
by
hesperetin
with
reductions
55.92,
34.98,
42.87,
24.70%
atherosclerotic
plaque
rate
control,
respectively.
Oral
naringin
mainly
existed
intestine
due
high
water
solubility
7-O-nohesperidoside
alleviated
atherosclerosis
enhancing
bile
acid
synthesis
gut
microbiota-FXR/FGF15-CYP7A1
pathway.
other
three
liver
after
absorption
from
intestine.
Hesperidin
upregulates
ABCA1
1.8-fold
enhance
cholesterol
reverse
transport,
while
aglycones
naringenin
inhibited
via
downregulating
HMGCR
2.4-
2.3-fold,
Hesperetin
was
more
resistant
than
existence
a
4'-methoxyl
group
relatively
weak
effects
on
alleviation
tightly
related
differences
their
vivo
pathways.
This
provides
new
insights
into
anti-atherosclerotic
mechanisms
food
functional
guidance
for
design
novel,
efficient
strategies
preventing
based
flavanones.
