Journal of Agricultural and Food Chemistry,
Journal Year:
2022,
Volume and Issue:
70(38), P. 11944 - 11957
Published: Sept. 19, 2022
Dietary
saponins
have
the
potential
to
ameliorate
atherosclerosis
(AS).
Gypenosides
of
Gynostemma
pentaphyllum
(GPs)
been
used
as
functional
foods
exhibit
antiatherosclerotic
activity.
The
present
study
aimed
explore
protective
effect,
underlying
mechanism
and
active
substances
GPs
on
AS
in
vivo
vitro.
Results
demonstrated
administration
reduced
serum
concentrations
TC
LDL-C,
upregulated
plasma
HDL-C
content,
inhibited
secretion
ICAM-1,
VCAM-1,
MCP-1,
alleviated
vascular
lesions
VitD3
plus
high
cholesterol
diet-induced
rats
well
adhesion
factors
levels
ox-LDL-stimulated
HUVECs,
which
was
potentially
associated
with
suppressing
PCSK9/LOX-1
pathway.
Further
activity-guided
phytochemical
investigation
led
identification
five
new
dammarane-type
glycosides
(1–5)
ten
known
analogs
(6–15).
Bioassay
evaluation
showed
compounds
1,
6,
7,
12,
13,
14
observably
expressions
PCSK9
LOX-1,
injured
HUVECs.
Molecular
docking
experiments
suggested
that
might
bind
allosteric
pocket
located
at
catalytic
C-terminal
domains,
2α–OH-protopanaxadiol-type
gypenosides
exert
a
higher
affinity
for
an
binding
site
by
hydrogen-bond
interaction
ARG-458.
These
findings
provide
insights
into
nutraceutical
application
their
bioactive
prevention
discovery
novel
therapeutic
strategies
AS.
Antioxidants,
Journal Year:
2022,
Volume and Issue:
11(2), P. 239 - 239
Published: Jan. 26, 2022
The
increased
consumption
of
fruits,
vegetables,
and
whole
grains
contributes
to
the
reduced
risk
many
diseases
related
metabolic
syndrome,
including
neurodegenerative
diseases,
cardiovascular
disease
(CVD),
diabetes,
cancer.
Citrus,
genus
Citrus
L.,
is
one
most
important
fruit
crops,
rich
in
carotenoids,
flavonoids,
terpenes,
limonoids,
other
bioactive
compounds
nutritional
nutraceutical
value.
Moreover,
polymethoxylated
flavones
(PMFs),
a
unique
class
abundantly
occur
citrus
fruits.
In
addition,
essential
oil,
limonoids
an
economically
product
due
its
potent
antioxidant,
antimicrobial,
flavoring
properties.
Mechanistic,
observational,
intervention
studies
have
demonstrated
health
benefits
bioactives
minimizing
syndrome.
This
review
provides
comprehensive
view
composition
fruits
their
associated
benefits.
Critical Reviews in Food Science and Nutrition,
Journal Year:
2021,
Volume and Issue:
63(14), P. 2018 - 2041
Published: Oct. 5, 2021
Citrus
fruits
are
consumed
in
large
quantities
worldwide
due
to
their
attractive
aromas
and
taste,
as
well
high
nutritional
values
various
health-promoting
effects,
which
abundance
of
nutrients
bioactives.
In
addition
water,
carbohydrates,
vitamins,
minerals,
dietary
fibers
important
citrus,
providing
them
with
values.
also
rich
bioactives
such
flavonoids,
essential
oils,
carotenoids,
limonoids,
synephrines,
protect
from
ailments,
including
cancer
inflammatory,
digestive,
cardiovascular
diseases.
The
composition
content
differ
significantly
among
citrus
varieties,
fruit
parts,
growth
stages.
To
better
understand
the
nutrient
bioactive
profiles
provide
guidance
for
utilization
high-value
resources,
this
review
systematically
summarizes
fruit,
contents,
structural
characteristics,
potential
health
benefits.
We
explore
variation
different
stages,
effects
applications.
Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
164, P. 114990 - 114990
Published: June 12, 2023
Although
a
growing
body
of
research
has
recently
shown
how
crucial
inflammation
and
infection
are
to
all
major
diseases,
several
the
medications
currently
available
on
market
have
various
unfavourable
side
effects,
necessitating
development
alternative
therapeutic
choices.
Researchers
increasingly
interested
in
or
active
components
derived
from
natural
sources.
Naringenin
is
commonly
consumed
flavonoid
found
many
plants,
since
it
was
discovered
nutritional
benefits,
been
utilized
treat
infections
caused
by
particular
bacteria
viruses.
However,
absence
adequate
clinical
data
naringenin's
poor
solubility
stability
severely
restrict
its
usage
as
medicinal
agent.
In
this
article,
we
discuss
effects
mechanisms
action
autoimmune-induced
inflammation,
bacterial
infections,
viral
based
recent
research.
We
also
present
few
suggestions
for
enhancing
solubility,
stability,
bioavailability.
This
paper
emphasizes
potential
use
naringenin
an
anti-inflammatory
anti-infective
agent
next
prophylactic
substance
treatment
inflammatory
infectious
even
though
some
still
unclear,
offers
theoretical
support
application.
Foods,
Journal Year:
2022,
Volume and Issue:
11(11), P. 1551 - 1551
Published: May 25, 2022
Colitis
has
become
a
major
health
concern
worldwide.
The
objective
of
the
present
study
was
to
determine
probiotic
influence
different
strains
B.
pseudolongum
(Bp7
and
Bp8)
on
alleviating
colitis
explore
its
possible
potential
mechanisms.
Our
results
displayed
that
Bp7
Bp8
intervention
effectively
reduced
dextran
sodium
sulfate
(DSS)-caused
body
weight
loss
release
several
pro-inflammatory
factors
(interleukin
(IL)-6,
IL-1β,
tumor
necrosis
factor-α
(TNF-α))
increased
activities
antioxidant
enzymes
(T-AOC,
SOD,
GSH)
concentrations
tight
junction
proteins
(occludin,
claudin-1,
ZO-1).
Moreover,
drastically
down-regulated
expression
colonic
MyD88,
NF-κB,
iNOS
COX2
elevated
STAT3,
Nrf2,
PPARγ.
Gas
chromatography-mass
spectrometry
revealed
cecal
levels
isobutyric,
butyric,
isovaleric
acids
were
in
mice
intervened
with
Bp8.
16S
rRNA
sequencing
modulated
intestinal
microbiota
structure,
particularly
by
enhancing
proportion
Eubacterium
coprostanoligenes
group,
Marvinbryantia,
Enterorhabdus,
Faecalibaculum,
Coriobacteriaceae
UCG
002,
Alistipes,
Bifidobacterium,
which
are
relevant
isobutyric
acid,
butyric
inflammatory
cytokines.
Collectively,
these
findings
suggest
alleviates
barrier
function,
possibly
blocking
secretion
proinflammatory
cytokines,
maintaining
physical
integrity,
activating
PPARγ/STAT3
pathway,
modulating
composition.
also
suggested
is
promising
for
treatment.
Frontiers in Nutrition,
Journal Year:
2022,
Volume and Issue:
9
Published: July 18, 2022
Since
the
dietary
regimen
rich
in
fruits
is
being
widely
recognized
and
encouraged,
Citrus
L.
have
been
growing
popularity
worldwide
due
to
their
high
amounts
of
health-promoting
phytonutrients
bioactive
compounds,
such
as
flavonoids,
phenolic
acids,
vitamins,
carotenoids,
pectins,
fatty
acids.
The
diverse
physicochemical
properties
multiple
utilization
citrus
food
industry
are
associated
with
unique
chemical
compositions.
Throughout
world,
has
used
for
producing
various
value-added
nutritionally
enhanced
products,
including
juices,
wines,
jams,
canned
citrus,
dried
citrus.
However,
current
studies
regarding
phytochemical
nutritional
characteristics
applications
scattered.
This
review
systematically
summarizes
existing
bibliography
on
characteristics,
functional
nutraceutical
benefits,
processing,
potential
A
thorough
understanding
this
information
may
provide
scientific
guidance
better
utilizing
a
fruit
benefit
extension
value
chain.
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(9), P. 1321 - 1321
Published: April 28, 2024
Imbalances
in
lipid
uptake
and
efflux
inflammation
are
major
contributors
to
foam
cell
formation,
which
is
considered
a
therapeutic
target
protect
against
atherosclerosis.
Naringin,
citrus
flavonoid
abundant
fruits,
has
been
reported
exert
an
antiatherogenic
function,
but
its
pharmacological
mechanism
unclear.
Naringin
treatment
effectively
inhibits
formation
THP-1
RAW264.7
macrophages.
In
this
study,
mechanically,
naringin
maintained
homeostasis
within
macrophages
through
downregulation
of
the
key
genes
for
(MSR1
CD36)
upregulation
ABCA1,
ABCG1
SR-B1,
responsible
cholesterol
efflux.
Meanwhile,
significantly
decreased
synthesis-related
increased
involved
metabolism.
Subsequently,
results
showed
that
ox-LDL-induced
macrophage
inflammatory
responses
were
inhibited
by
reducing
proinflammatory
cytokines
IL-1β,
IL-6
TNF-α,
increasing
anti-
cytokine
IL-10,
was
further
verified
pro-inflammatory
chemokine-related
genes.
Additionally,
we
found
reprogrammed
metabolic
phenotypes
suppressing
glycolysis
promoting
oxidation
metabolism
restore
functions.
These
suggest
potential
drug
AS
as
it
regulating
inflammation.
Journal of Advanced Research,
Journal Year:
2022,
Volume and Issue:
47, P. 189 - 207
Published: June 16, 2022
Chronic
psychological
stress
is
a
well-established
risk
factor
for
breast
cancer
development.
Si-Ni-San
(SNS)
classical
traditional
Chinese
medicine
formula
prescribed
to
disorder
patients.
However,
its
action
effects,
molecular
mechanisms,
and
bioactive
phytochemicals
against
are
not
yet
clear.
This
study
aimed
explore
the
modulatory
mechanism
compound
of
SNS
in
regulating
estrogen
metabolism
during
development
induced
by
chronic
stress.
Mouse
xenograft
was
used
determine
effect
on
growth
metastasis.
Metabolomics
analysis
conducted
discover
impact
metabolic
profile
changes
vivo.
Multiple
biology
experiments
xenografts
were
applied
verify
anti-metastatic
potentials
screened
compound.
remarkably
inhibited
stress-induced
metastasis
mouse
xenograft.
Meanwhile,
increased
level
cholic
acid,
accompanied
elevation
estradiol.
Mechanistic
investigation
demonstrated
that
acid
activated
farnesoid
X
receptor
(FXR)
expression,
which
hepatocyte
nuclear
4α
(HNF4α)-mediated
sulfotransferase
(EST)
transcription
hepatocytes,
finally
resulting
estradiol
elevation.
Notably,
suppressing
via
modulating
FXR/EST
signaling.
Furthermore,
luciferase-reporting
gene
assay
naringenin
as
most
triggering
EST
activity
hepatocytes.
Interestingly,
pharmacokinetic
revealed
had
highest
absorption
liver
tissue.
Following
vivo
vitro
studies
promoting
only
highlights
signaling
crucial
target
mediating
development,
but
also
provides
potential
candidate
endocrine
therapy
metabolism.
