Veterinary Microbiology, Journal Year: 2023, Volume and Issue: 288, P. 109948 - 109948
Published: Dec. 12, 2023
Language: Английский
Chinese Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 44(7), P. 2305 - 2305
Published: Jan. 1, 2024
Language: Английский
Citations
0
Animals, Journal Year: 2024, Volume and Issue: 14(21), P. 3062 - 3062
Published: Oct. 24, 2024
Interferons (IFNs) stimulate the expression of numerous IFN-stimulating genes via Janus kinase-signal transducers and activators transcription (JAK-STAT) signaling pathway, which plays an important role in host defense against viral infections. In mammals, including humans mice, a substantial number IFN-stimulated (ISGs) have been identified, their molecular mechanisms elucidated. It is to note that avian species are phylogenetically distant from resulting distinct IFN-induced ISGs may different functions. At present, only limited identified. this review, we summarized identified antiviral activities. As gene-editing technology widely used breeding, identification elucidation mechanism provide support for breeding avians disease resistance.
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(19), P. 10489 - 10489
Published: Sept. 29, 2024
Infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cause disease 2019 (COVID-19), a very heterogeneous symptoms. Dyslipidaemia is prevalent in at least 20% of Europeans, and dyslipidaemia before SARS-CoV-2 infection increases the risk for COVID-19 mortality by 139%. Many reports described reduced serum cholesterol levels virus-infected patients, particular those disease. The liver major organ lipid homeostasis hepatic dysfunction appears to occur one five patients infected SARS-CoV-2. Thus, infection, severity injury may be related impaired homeostasis. These observations prompted efforts assess therapeutic opportunities cholesterol-lowering medications reduce severity. majority studies implicate statins have beneficial effects on outcome COVID-19. Proprotein convertase subtilisin/kexin type 9 (PCSK9) antibodies also shown potential protect against This review describes relationship between systemic levels, PCSK9 are summarised. Finally, lung function, first affected SARS-CoV-2, described.
Language: Английский
Citations
0
Veterinary Microbiology, Journal Year: 2024, Volume and Issue: 298, P. 110284 - 110284
Published: Oct. 22, 2024
Language: Английский
Citations
0
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown
Published: June 15, 2023
Abstract The human intestinal enteroid (HIE) cell culture system with the support of glycine-conjugated bile acid glycochenodeoxycholic (GCDCA) and ceramide (C2) facilitate successful replication several norovirus strains. Here we investigate how presence GCDCA/C2 impacts gene expression norovirus-infected HIE impact 25 hydroxycholesterol (25-HC), a key regulator cholesterol homeostasis production on replication. In absence GCDCA/C2, 0.01 0.1 μM 25-HC suppressed virus (GII.4 Sydney[P16]) by 1.3 log 1.1 respectively (p<0.05). 5 was required to achieve 1 decrease (p<0.05) in viral titers demonstrating that restricts HIE. RNA sequence analysis showed during infection, downregulated genes (CYP3A4, APOB, APOA1, ABCG1) involved metabolism transport as well interferon stimulated such ISG15 IFIT1. counteracts suppressive effect some related these pathways including APOA4 CYP27A1 however, other APOA1 were further GCDCA/C2. Importance Norovirus is leading cause epidemic endemic acute gastroenteritis worldwide currently, there are no effective therapeutic strategies against this highly contagious pathogen. Our study provides insights into highlight role cholesterol/oxysterol replication, demonstrate potential utility oxysterols developing therapeutics.
Language: Английский
Citations
0
Veterinary Microbiology, Journal Year: 2023, Volume and Issue: 288, P. 109948 - 109948
Published: Dec. 12, 2023
Language: Английский
Citations
0