Cellular and molecular mechanisms of oroxylin A in cancer therapy: Recent advances DOI
Pengxin Wang,

Xiao-Nan Mu,

Shuhong Huang

et al.

European Journal of Pharmacology, Journal Year: 2024, Volume and Issue: 969, P. 176452 - 176452

Published: Feb. 28, 2024

Language: Английский

Preparation of colon-targeted alginate microspheres loaded with the honokiol-doxorubicin conjugate and their therapeutic effect on colon cancer DOI
Limei Zhang,

Huatai Zhu,

Peng Ye

et al.

Particuology, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Artificial cells and Biomimicry cells: A Rising Star in the Fight Against Cancer DOI Creative Commons

Renata Faria Maia,

Asma Sadat Vaziri, Mohammad‐Ali Shahbazi

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101723 - 101723

Published: April 1, 2025

Biomimetic Artificial Cells (ACs) are engineered systems that mimic the properties and functions of natural cells, offering significant potential for biomedical applications. The performance applicability these synthetic constructs depend on choice materials fabrication methods. Our review delves into materials, techniques, diverse applications ACs, emphasizing their transformative impact field cancer therapy as smart vehicles drug delivery, immune system stimulation, cell targeting to minimize off-target effects maximizing therapeutic efficacy well in vitro models research. By providing a comprehensive overview, we aim elucidate how cells can move forward, innovative solutions longstanding challenges treatment opening new frontiers less toxic options.

Language: Английский

Citations

0
Silver Nanoparticles Decorated UiO-66-NH2 Metal-Organic Framework for Combination Therapy in Cancer Treatment DOI Creative Commons
Francesco Ragonese,

Letizia Trovarelli,

Lorenzo Monarca

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(4), P. 512 - 512

Published: April 13, 2025

Background: Nanomedicine has shown significant promise in advancing cancer diagnostics and therapeutics. In particular, nanoparticles (NPs) offer potential for overcoming limitations associated with conventional therapies, such as off-target toxicity side effects. Among the various NPs, silver (AgNPs) have garnered attention due to their cytotoxic genotoxic properties cells. However, despite potential, optimization of AgNPs efficacy often necessitates combination strategies other therapeutic agents. This study explores integrated Zr-based metal-organic frameworks (MOFs) UiO-66 drug delivery, enhance therapy. Methods: We decorated amino-terephthalic based UiO-66-NH2 loaded it chemotherapeutic agent cisplatin (Cis-Pt) make UiO-66-NH2@AgNPs@Cis-Pt. A preliminary MTT assay was conducted evaluate effects nanocomposite on several glioblastoma tumour cell lines, including U251, U87, GL261, HeLa, RKO, HepG2. Results: Our results demonstrate that UiO-66-NH2@AgNPs@Cis-Pt its combinations exhibit enhanced cytotoxicity compared individual components Cis-Pt. Conclusions: work offers insights into AgNP-functionalized MOFs effective delivery platforms, particularly context therapy treatment.

Language: Английский

Citations

0
Clinical and pathological factors associated with survival in patients with pancreatic cancer who receive adjuvant therapy after neoadjuvant therapy: A retrospective multi-institutional analysis DOI
Takayuki Shimizu,

Shimpei Maeda,

Jason M. Link

et al.

Surgery, Journal Year: 2024, Volume and Issue: 175(5), P. 1377 - 1385

Published: Feb. 16, 2024

Language: Английский

Citations

3
Cellular and molecular mechanisms of oroxylin A in cancer therapy: Recent advances DOI
Pengxin Wang,

Xiao-Nan Mu,

Shuhong Huang

et al.

European Journal of Pharmacology, Journal Year: 2024, Volume and Issue: 969, P. 176452 - 176452

Published: Feb. 28, 2024

Language: Английский

Citations

3