Agarwood as a potential therapeutic for Alzheimer's disease: Mechanistic insights and target identification DOI Open Access
Yanan Ma,

Xiqi Hu,

Kenji Karako

et al.

Drug Discoveries & Therapeutics, Journal Year: 2024, Volume and Issue: 18(6), P. 375 - 386

Published: Dec. 20, 2024

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, memory loss, and functional impairments. Despite extensive research, its pathogenesis remains incompletely understood, effective treatments are limited. This study explored the therapeutic potential of agarwood in AD integrating network pharmacology, protein-protein interaction (PPI) analysis, single-cell expression analysis. The results revealed that compounds may modulate key inflammatory genes such as NFKB1, STAT1, TLR4, alleviating neuroinflammation; enhance HSP90 regulate KDR signaling to improve blood-brain barrier (BBB) integrity; promote activity PTPN11 CXCR4 support oligodendrocyte precursor cell (OPC) repair remyelination. Single-cell analysis highlighted cell-type-specific patterns, particularly OPCs endothelial cells, underscoring their relevance pathology. Agarwood's multi-dimensional positions it promising candidate for development novel treatments.

Language: Английский

Sulfonic acid functionalized β-amyloid peptide aggregation inhibitors and antioxidant agents for the treatment of Alzheimer's disease: Combining machine learning, computational, in vitro and in vivo approaches DOI
Vinit Raj, Chaitany Jayprakash Raorane,

Divya Shastri

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140142 - 140142

Published: Jan. 1, 2025

Language: Английский

Citations

0
Harnessing network pharmacology and in silico drug discovery to uncover new targets and therapeutics for Alzheimer's disease DOI
Haitham Al‐Madhagi,

Husam Nassar

Computers in Biology and Medicine, Journal Year: 2025, Volume and Issue: 187, P. 109781 - 109781

Published: Feb. 5, 2025

Language: Английский

Citations

0
Agarwood as a potential therapeutic for Alzheimer's disease: Mechanistic insights and target identification DOI Open Access
Yanan Ma,

Xiqi Hu,

Kenji Karako

et al.

Drug Discoveries & Therapeutics, Journal Year: 2024, Volume and Issue: 18(6), P. 375 - 386

Published: Dec. 20, 2024

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, memory loss, and functional impairments. Despite extensive research, its pathogenesis remains incompletely understood, effective treatments are limited. This study explored the therapeutic potential of agarwood in AD integrating network pharmacology, protein-protein interaction (PPI) analysis, single-cell expression analysis. The results revealed that compounds may modulate key inflammatory genes such as NFKB1, STAT1, TLR4, alleviating neuroinflammation; enhance HSP90 regulate KDR signaling to improve blood-brain barrier (BBB) integrity; promote activity PTPN11 CXCR4 support oligodendrocyte precursor cell (OPC) repair remyelination. Single-cell analysis highlighted cell-type-specific patterns, particularly OPCs endothelial cells, underscoring their relevance pathology. Agarwood's multi-dimensional positions it promising candidate for development novel treatments.

Language: Английский

Citations

1