Journal of Cellular Physiology, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 13, 2024
Liver fibrosis is one of the leading cause death worldwide. In liver, hepatic stellate cells are primary cell type that gets activated during fibrosis. LX-2 human-derived lines typically employed for studying liver mechanisms and screening anti-fibrotic lead molecules. Although partially in culture conditions, numerous stimuli including TGF-β, H
Language: Английский
Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106104 - 106104
Published: Feb. 1, 2025
Language: Английский
Citations
1
Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106153 - 106153
Published: Feb. 1, 2025
Language: Английский
Citations
1
Medical and Veterinary Entomology, Journal Year: 2025, Volume and Issue: unknown
Published: April 19, 2025
Abstract The Aedes aegypti mosquito is generally associated with arboviruses that cause yellow fever, dengue, zika and chikungunya. most efficient way to control their populations through application in breeding sites of highly toxic insecticides can also impact non‐target organisms generate resistant populations. Therefore, the use compounds desirable. Morin hydrate has broad pharmacological applications based on its antioxidant potential, addition not having negative effects mammals. objective present study was investigate morin A. survival, pupation rate, egg laying, triacylglycerol reserves expression proteins related lipid metabolism 24 h after exposure larvae. For this, rearing media containing larvae different concentrations were formulated evaluate lethal concentration. Calculation expected showed LC 25 52.692 μM, 40 111.121 50 174.775 75 575.083 μM 90 1685.936 μM. Twenty‐four hours treatment hydrate, surviving transferred morin‐free water food, rate fertility evaluated. We observed an increase concentration induced a dose‐dependent reduction doubled time survivors reduced number eggs laid by treated females during larval stage approximately 30% at exceeding 100 From (TAG) stock evaluated, evaluating involved metabolism. Larvae TAG 17%, while 175 there more than 33% stocks, 500 61%. Furthermore, lipolytic TAGL1 HSL upregulated, lipogenic FAS1, DGAT1 GPAT1 downregulated. Insulin‐like receptors downregulated, unlike AKHr, which upregulated. These data demonstrate reduces survival affecting did exhibit toxicity toward organisms, demonstrating interesting potential for
Language: Английский
Citations
0
Phytotherapy Research, Journal Year: 2025, Volume and Issue: unknown
Published: May 1, 2025
ABSTRACT Obesity, along with its associated health risks such as hypertension, hyperlipidemia, Type 2 diabetes, stroke, metabolic syndrome, asthma, and cancer, constitutes a significant global burden, contributing substantially to morbidity mortality. Cytokines, group of secreted signaling proteins, are crucial in initiating, maintaining, resolving immune responses. Although cytokines have unique advantages regulating functions, their therapeutic application for obesity remains limited clinical practice. Natural compounds, known structural diversity low toxicity, become valuable resource drug development. Many natural compounds shown anti‐obesity effects. This review comprehensively examines the mechanisms underlying obesity, specific focus on roles cytokines, inflammatory adipokines, growth factors. Additionally, it highlights regulatory interactions between gut microbiota obesity. The critically analyzes current pharmacological interventions summarizes advanced methodologies identifying potential compounds. Finally, identifies promising that modulate cytokine activity prevent or treat assesses complementary alternative therapies.
Language: Английский
Citations
0
Food Bioscience, Journal Year: 2024, Volume and Issue: 61, P. 104897 - 104897
Published: Aug. 8, 2024
Language: Английский
Citations
3
Life, Journal Year: 2024, Volume and Issue: 14(8), P. 945 - 945
Published: July 28, 2024
Obesity has become a widespread issue globally. Morin, flavonoid with traditional use in managing hyperglycemia and hyperlipidemia, demonstrated antioxidant anti-inflammatory properties experimental studies. This research aims to explore the anti-obesity potential of morin rats subjected high-fat diet (HFD) investigate whether its effects are mediated through PPARα regulation.
Language: Английский
Citations
1
Food Bioscience, Journal Year: 2024, Volume and Issue: 62, P. 105427 - 105427
Published: Nov. 7, 2024
Language: Английский
Citations
1
Journal of Cellular Physiology, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 13, 2024
Liver fibrosis is one of the leading cause death worldwide. In liver, hepatic stellate cells are primary cell type that gets activated during fibrosis. LX-2 human-derived lines typically employed for studying liver mechanisms and screening anti-fibrotic lead molecules. Although partially in culture conditions, numerous stimuli including TGF-β, H
Language: Английский
Citations
0