Acetylcholine Sustains LNCaP Prostate Cancer Cell Migration, Invasion and Proliferation Through Glyoxalase 1/MG-H1 Axis with the Involvement of Osteopontin DOI Open Access

Dominga Manfredelli,

Tatiana Armeni, Lidia de Bari

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 4107 - 4107

Published: April 25, 2025

The neurotransmitter acetylcholine (ACh) plays a pro-carcinogenic role in various cancer types, including prostate (PCa). existing body of knowledge concerning the mechanisms that underpin protumoral ACh PCa is limited. Glyoxalase 1 (Glo1) metabolic enzyme removes methylglyoxal (MG), an endogenous post-translational modification agent, generating 5-hydro-5-methylimidazolone (MG-H1). Glo1/MG-H1 axis involved tumorigenesis and progression. By using LNCaP PC3 cells, representing extensively studied cell models poorly aggressive bone metastasis-derived PCa, respectively, we found specifically sustains migration, invasion proliferation through Glo1-dependent MG-H1 accumulation with involvement osteopontin (OPN), thus providing novel mechanism underlying ACh’s cells. findings this study unveil hitherto unidentified implicated progression which initiated by involves both OPN. This discovery provides basis for new avenues vivo investigation into physiological relevance roles ACh-driven OPN further research aimed at exploring ways managing progression, aim preventing disease from becoming incurable.

Language: Английский

Advances in Nanoparticles in Targeted Drug Delivery- A Review DOI Creative Commons
Safiul Islam, Md Mir Shakib Ahmed, Mohammad Aminul Islam

et al.

Results in Surfaces and Interfaces, Journal Year: 2025, Volume and Issue: unknown, P. 100529 - 100529

Published: April 1, 2025

Language: Английский

Citations

0
Lactoferrin in cancer: Focus on mechanisms and translational medicine DOI
Zhengyu Hu, Wenchao Li, Lingyu Wei

et al.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2025, Volume and Issue: unknown, P. 189330 - 189330

Published: April 1, 2025

Language: Английский

Citations

0
Acetylcholine Sustains LNCaP Prostate Cancer Cell Migration, Invasion and Proliferation Through Glyoxalase 1/MG-H1 Axis with the Involvement of Osteopontin DOI Open Access

Dominga Manfredelli,

Tatiana Armeni, Lidia de Bari

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 4107 - 4107

Published: April 25, 2025

The neurotransmitter acetylcholine (ACh) plays a pro-carcinogenic role in various cancer types, including prostate (PCa). existing body of knowledge concerning the mechanisms that underpin protumoral ACh PCa is limited. Glyoxalase 1 (Glo1) metabolic enzyme removes methylglyoxal (MG), an endogenous post-translational modification agent, generating 5-hydro-5-methylimidazolone (MG-H1). Glo1/MG-H1 axis involved tumorigenesis and progression. By using LNCaP PC3 cells, representing extensively studied cell models poorly aggressive bone metastasis-derived PCa, respectively, we found specifically sustains migration, invasion proliferation through Glo1-dependent MG-H1 accumulation with involvement osteopontin (OPN), thus providing novel mechanism underlying ACh’s cells. findings this study unveil hitherto unidentified implicated progression which initiated by involves both OPN. This discovery provides basis for new avenues vivo investigation into physiological relevance roles ACh-driven OPN further research aimed at exploring ways managing progression, aim preventing disease from becoming incurable.

Language: Английский

Citations

0