Polymers,
Journal Year:
2025,
Volume and Issue:
17(8), P. 1101 - 1101
Published: April 18, 2025
Pancreatic
ductal
adenocarcinoma
(PDAC)
is
one
of
the
deadliest
cancers
worldwide
due
to
its
resistance
conventional
therapies
that
attributed
dense
and
acidic
tumor
microenvironment.
Chemotherapy
based
on
gemcitabine
usually
lacks
efficacy
poor
drug
penetration
metabolic
characteristics
cells
adapted
grow
at
a
more
pHe,
thus
presenting
aggressive
phenotype.
In
this
context,
photodynamic
therapy
(PDT)
offers
promising
alternative
since
it
generally
does
not
suffer
from
same
patterns
cross-resistance
observed
with
chemotherapy
drugs.
present
work,
novel
bromine-substituted
heptamethine-cyanine
dye
(BrCY7)
was
synthesized,
loaded
into
PEG-PLGA
NPs,
tested
pancreatic
cell
line
cultured
under
physiological
(PANC-1
CT)
pH
selected)
conditions,
which
promotes
selection
The
cytotoxicity
BrCY7-PEG-PLGA
dose-dependent,
an
IC50
2.15
µM
in
PANC-1
CT
2.87
selected.
Notably,
demonstrated
phototoxic
effect
against
selected
but
CT,
makes
these
findings
particularly
relevant
are
resistant
as
compared
cells.
Advanced Science,
Journal Year:
2021,
Volume and Issue:
8(3)
Published: Jan. 5, 2021
Phototherapy
such
as
photothermal
therapy
and
photodynamic
in
cancer
treatment
has
been
developed
quickly
over
the
past
few
years
for
its
noninvasive
nature
high
efficiency.
However,
there
are
still
many
drawbacks
phototherapy
that
prevent
it
from
clinical
applications.
Thus,
scientists
have
designed
different
systems
to
overcome
issues
associated
with
phototherapy,
including
enhancing
targeting
ability
of
low-temperature
therapy,
replacing
near-infrared
light
other
excitation
sources,
so
on.
This
article
discusses
problems
shortcomings
encountered
development
highlights
possible
solutions
address
them
may
become
a
useful
approach
practice.
aims
give
brief
summary
about
current
research
advancements
provides
quick
guideline
toward
future
developments
field.
Nanoscale Advances,
Journal Year:
2024,
Volume and Issue:
6(9), P. 2270 - 2286
Published: Jan. 1, 2024
Breast
cancer
is
a
global
health
challenge
with
staggering
statistics
underscoring
its
pervasive
impact.
The
burden
of
this
disease
measured
in
terms
prevalence
and
the
challenges
it
poses
to
healthcare
systems,
necessitating
closer
look
at
epidemiology
Current
breast
treatments,
including
surgery,
chemotherapy,
radiation
therapy,
targeted
therapies,
have
made
significant
strides
improving
patient
outcomes.
However,
they
are
not
without
limitations,
often
leading
adverse
effects
development
drug
resistance.
This
comprehensive
review
delves
into
complex
landscape
cancer,
incidence,
current
treatment
modalities,
inherent
limitations
existing
therapeutic
approaches.
It
also
sheds
light
on
promising
role
nanotechnology,
encompassing
both
inorganic
organic
nanoparticles
equipped
ability
selectively
deliver
agents
tumor
sites,
battle
against
cancer.
addresses
emerging
their
associated
challenges,
future
prospects
delivery
management.
Materials Advances,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Cancer,
a
major
health
challenge
worldwide,
is
accountable
for
large
percentage
of
disease-related
deaths.
Annually,
new
cancer
diagnosis
reaches
over
10
million
with
record
about
9.6
deaths....
Acta Pharmaceutica Sinica B,
Journal Year:
2020,
Volume and Issue:
11(8), P. 2197 - 2219
Published: Dec. 21, 2020
Many
sensitizers
have
not
only
photodynamic
effects,
but
also
sonodynamic
effects.
Therefore,
the
combination
of
therapy
(SDT)
and
(PDT)
using
for
sono-photodynamic
(SPDT)
provides
alternative
opportunities
clinical
cancer
therapy.
Although
significant
advances
been
made
in
synthesizing
new
SPDT,
few
them
are
successfully
applied
settings.
The
anti-tumor
effects
restricted
by
lack
tumor-targeting
specificity,
incapability
deep
intratumoral
delivery,
deteriorating
tumor
microenvironment.
application
nanotechnology-based
drug
delivery
systems
(NDDSs)
can
solve
above
shortcomings,
thereby
improving
SPDT
efficacy.
This
review
summarizes
various
as
sono/photosensitizers
that
be
further
used
describes
different
strategies
enhancing
treatment
NDDSs,
such
overcoming
biological
barriers,
tumor-targeted
providing
stimuli-responsive
controlled-release
characteristics,
stimulating
immunity,
increasing
oxygen
supply,
employing
therapeutic
modalities,
combining
diagnosis
treatment.
challenges
prospects
development
intelligent
translational
NDDSs
discussed.
Molecular Cancer,
Journal Year:
2021,
Volume and Issue:
20(1)
Published: March 24, 2021
Abstract
Background
As
a
complement
to
the
clinical
development
of
new
anticancer
molecules,
innovations
in
therapeutic
vectorization
aim
at
solving
issues
related
tumor
specificity
and
associated
toxicities.
Nanomedicine
is
rapidly
evolving
field
that
offers
various
solutions
increase
efficacy
safety.
Main
Here
are
presented
recent
advances
for
different
types
nanovectors
chemical
biological
nature,
identify
best
suited
translational
research
projects.
These
include
chemically
engineered
nanoparticles
now
come
many
flavors
‘smart’
drug
delivery
systems.
Alternatives
with
enhanced
biocompatibility
better
adaptability
molecules
cell-derived
extracellular
vesicles
micro-organism-derived
oncolytic
viruses,
virus-like
particles
bacterial
minicells.
In
first
part
review,
we
describe
their
main
physical,
properties
potential
personalized
modifications.
The
second
focuses
on
presenting
literature
use
families
deliver
chemotherapy,
radiotherapy,
nucleic
acid-based
therapy,
modulation
microenvironment
immunotherapy.
Conclusion
This
review
will
help
readers
appreciate
complexity
available
most
fitting
“type”
efficient
specific
diverse
therapies.
